Rutin and Quercetin Decrease Cholesterol in HepG2 Cells but Not Plasma Cholesterol in Hamsters by Oral Administration

Rutin (R) and quercetin (Q) are two widespread dietary flavonoids. Previous studies regarding the plasma cholesterol-lowering activity of R and Q generated inconsistent results. The present study was therefore carried out to investigate the effects of R and Q on cholesterol metabolism in both HepG2 cells and hypercholesterolemia hamsters. Results from HepG2 cell experiments demonstrate that both R and Q decreased cholesterol at doses of 5 and 10 µM. R and Q up-regulated both the mRNA and protein expression of sterol regulatory element binding protein 2 (SREBP2), low-density lipoprotein receptor (LDLR), and liver X receptor alpha (LXRα). The immunofluorescence study revealed that R and Q increased the LDLR expression, while only Q improved LDL-C uptake in HepG2 cells. Results from hypercholesterolemia hamsters fed diets containing R (5.5 g/kg diet) and Q (2.5 g/kg diet) for 8 weeks demonstrate that both R and Q had no effect on plasma total cholesterol. In the liver, only Q reduced cholesterol significantly. The discrepancy between the in vitro and in vivo studies was probably due to a poor bioavailability of flavonoids in the intestine. It was therefore concluded that R and Q were effective in reducing cholesterol in HepG2 cells in vitro, whereas in vivo, the oral administration of the two flavonoids had little effect on plasma cholesterol in hamsters.     

Quantum Switchboard with Coupled-Cavity Array

The ability to control the flow of quantum information is deterministically useful for scaling up quantum computation. In this paper, we demonstrate a controllable quantum switchboard which directs the teleportation protocol to one of two targets, fully dependent on the sender’s choice. Importantly, the quantum switchboard also acts as a optimal quantum cloning machine, which allows the receivers to recover the unknown quantum state with a maximal fidelity of 56. This protects the system from the complete loss of quantum information in the event that the teleportation protocol fails. We also provide an experimentally feasible physical implementation of the proposal using a coupled-cavity array. The proposed switchboard can be utilized for the efficient routing of quantum information in a large quantum network.     

Crosslinking of ethylene-propylene (-diene) terpolymer elastomer initiated by an excimer laser

Excimer laser-induced crosslinking of ethylene-propylene-diene elastomer using a trace amount of photoinitiator, 1-hydroxy cyclohexyl phenyl ketone, was evaluated. Gel content measurements on irradiated samples showed that crosslinking was a natural consequence in all, which had undergone exposure to laser radiation. Degree of crosslinking was found to be linear with the laser exposure energy and was found to reach a saturation value of approximately 80% at about 100 J. However, for thicker samples the dependence of gel content i.e. crosslinking was found to be exponential over the range of laser exposure energy in excess of 200 J. As is expected, the tensile strength increased significantly with the increase of crosslinking. The band at 808 cm⁻¹ in the infrared spectra was attributed to the 5-ethylidene-2-norbornene (ENB) content in the polymer. The ENB has a double bond which is considered to be consumed with a high radiochemical yield and thereby contributes to the increase in rate of the formation of intermolecular bridge density.     

Observation of geometric phases for mixed states using NMR interferometry

Examples of geometric phases abound in many areas of physics. They offer both fundamental insights into many physical phenomena and lead to interesting practical implementations. One of them, as indicated recently, might be an inherently fault-tolerant quantum computation. This, however, requires one to deal with geometric phases in the presence of noise and interactions between different physical subsystems. Despite the wealth of literature on the subject of geometric phases very little is known about this very important case. Here we report the first experimental study of geometric phases for mixed quantum states. We show how different they are from the well-understood, noiseless, pure-state case.     

Experimental quantum cloning with prior partial information

When prior partial information about a state to be cloned is available, it can be cloned with a fidelity higher than that of universal quantum cloning. We experimentally verify this intriguing relationship between the cloning fidelity and the prior information by reporting the first experimental optimal quantum state-dependent cloner, using nuclear magnetic resonance techniques. Our experiments may further cast important implications into many quantum information processing protocols.     

Quantitative conditions do not guarantee the validity of the adiabatic approximation

In this Letter, we point out that the widely used quantitative conditions in the adiabatic theorem are insufficient in that they do not guarantee the validity of the adiabatic approximation. We also reexamine the inconsistency issue raised by Marzlin and Sanders [Phys. Rev. Lett. 93, 160408 (2004)] and elucidate the underlying cause.     

Kinematic approach to the mixed state geometric phase in nonunitary evolution

A kinematic approach to the geometric phase for mixed quantal states in nonunitary evolution is proposed. This phase is manifestly gauge invariant and can be experimentally tested in interferometry. It leads to well-known results when the evolution is unitary.     

Probing multipartite entanglement in spin chain via structure factors

Multi-qubit entanglement could act as a useful resource for many quantum information communication and processing tasks like quantum networking processes. Genuine non-trivial multi-qubit entanglement could delineates quantum physics from classical physics. Detection of multipartite entanglement however is a theoretical and experimental challenge. A useful tool for this purpose are entanglement witnesses. Recently, we provide an analytical construction of multi-qubit entanglement witnesses using static structure factors (SSF) and study the robustness of the witnesses with respect to noise. In this article, we consider the effectiveness of the entanglement witness based on SSF for probing spin chain.     

Examination of the adiabatic approximation in open systems

We examine the notion of the adiabatic approximation in open systems by applying it to closed systems. Our results shows that the notion is equivalent to the standard adiabatic approximation if the systems are initially in eigenstates, and it leads to a more general expression if the systems are in mixed states.