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This paper presents a method to compute the sensitivities of displacements and natural frequencies to the changes in grid locations. The sensitivities are computed within
using the semi-analytical method via a
program. New software was developed to assist in the selection of design variables and plot the spatial variation of the sensitivities on the finite element model. Two example problems demonstrate the technique. 相似文献
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Ganeshpurkar Ankit Singh Ravi Shivhare Shalini Divya Kumar Devendra Gutti Gopichand Singh Ravibhushan Kumar Ashok Singh Sushil Kumar 《Molecular diversity》2022,26(3):1455-1479
Molecular Diversity - Structure-based drug design (SBDD) is an important in silico technique, used for the identification of enzyme inhibitors. Acetylcholinesterase (AChE), obtained from... 相似文献
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Three new high molecular weight bromotyrosine-related metabolites, , and , were isolated from the sponge Aplysina ( Verongia) fistularis forma fulva, and their structures were determined from high resolution 1H NMR and other spectroscopic data. The new metabolites are formally derived by combination of major segments of two known Aplysina metabolites and . 相似文献
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Pulaganti Vijaya Prasad Medi Shanker Avudoddi Venkanna Marapala Kumara Swamy K. Gopichand 《合成通讯》2018,48(9):1040-1044
A facile and efficient synthesis of pyrrole and pyrrole-fused heterocyclic compounds has been demonstrated. The current protocol involves the in situ generation of azomethine ylides which undergoes intermolecular cycloaddition reaction and subsequent treatment with DDQ provides the pyrrole and fused heterocyclic compounds in good yields. 相似文献
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Kaur Pushpinder Chaudhary Abha Katiyar Arti Singh Bikram Gopichand Singh Rakesh D. 《平面色谱法杂志一现代薄层色谱法》2012,25(5):415-419
JPC – Journal of Planar Chromatography – Modern TLC - A reverse phase high-performance thin-layer chromatography (RPHPTLC) method was developed for determination of vitexin, hyperoside,... 相似文献
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Nanoparticle-enhanced sensitivity of a nanogap-interdigitated electrode array impedimetric biosensor 总被引:1,自引:0,他引:1
Singh KV Bhura DK Nandamuri G Whited AM Evans D King J Solanki R 《Langmuir : the ACS journal of surfaces and colloids》2011,27(22):13931-13939
Interdigitated electrode (IDE) arrays with nanometer-scale gaps have been utilized to enhance the sensitivity of affinity-based detection. The geometry of nanogap IDEs was first optimized on the basis of simulations of the electric field and current density. It was determined that the gap (G) between the electrodes was the most important geometric parameter in determining the distribution and strength of the electric field and the current density compared to the width (W) and height (H) of the IDEs. Several devices were materialized and analyzed for their sensitivity to the electrochemical environment using faradic electrochemical impedance spectroscopy (EIS) as the detection technique. Nanogap optimized IDEs were then employed as biosensors for the label-free, affinity-based detection of antitissue transglutaminase antibodies (αtTG-Abs), a biomarker for the detection of autoimmune disorder celiac sprue, triggered by ingesting gluten. The label-free biosensor assay was found to be less sensitive compared to on-chip ELISA. Gold nanoparticles (GNPs) were then employed to improve the sensitivity of the nanogap IDE-based biosensor. With GNPs, the transducer sensitivity increased by 350% over that of label-free detection. The suitability of nanogap IDEs as biosensor transducers for EIS in label-free and GNP-labeled formats was established. The immunobiosensor assay detection sensitivity with the GNPs was found comparable to ELISA. 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - A reversed-phase high-performance thin-layer chromatography (RP-HPTLC) method was developed for the determination of flavonoids... 相似文献
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