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The nuclear receptor (NR) superfamily is composed of 48 members in humans and includes receptors for steroid hormones, thyroid hormone, various lipids and oxysterols. This superfamily has been a rich source of drug targets for myriad diseases including inflammation, cancer, and metabolic disorders. Approximately half of the superfamily have well characterized natural ligands whereas the remaining receptors are considered orphan receptors and remain a focus of a number of investigators assessing their ability to be regulated by ligands. Here, we review recent discoveries that yield important insight into the druggability of three orphan nuclear receptors: the retinoic acid receptor-like orphan receptors (RORs), peroxisome proliferator-activated receptor γ (PPARγ), and liver receptor homolog-1 (LRH-1).  相似文献   
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Pseudo-first order reaction rate constants of 5,10,15-tris(pentafluorophenyl)corrole Mn(V)-oxo (F15CMn(V)-oxo),5,15-bis(pentafluorophenyl)-10-(phenyl)corrole Mn(V)-oxo(F10CMn(V)-oxo),5,15- bis(phenyl)-10-(pentafluorophenyl)corrole Mn(V)-oxo(F5CMn(V)-oxo) and 5,10,15-tris(phenyl)corrole Mn(V)-oxo(F0CMn(V)-oxo) with a series of alkene substrates in different solvents were determined by UV-vis spectroscopy.The results indicated that the oxygen atom transfer pathway between Mn(V)-oxo corrole and alkene is solvent-dependent.  相似文献   
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Low energy electron beams (E approximately 300 keV) generated in a self-modulated laser wakefield accelerator experiment were observed to filament and be deflected away from the laser axis forming radial jets in the electron beam profile. At higher energies (E>900 keV), the filamentation and jets were suppressed and smooth electron beams copropagating with the laser were observed. The observed electron beam filamentation likely results from laser beam filamentation in the plasma due to relativistic self-focusing effects. The radial jets of low energy electrons are likely caused by transverse ejection of the electrons due to the radial structure of the wakefield and space charge deflection of electrons as they exit the laser focus.  相似文献   
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