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Brownian dynamics simulation of the cross-talking effect among modified histones on conformations of nucleosomes 下载免费PDF全文
Using Brownian dynamics simulation,we studied the effect of histone modifications on conformations of an array of nucleosomes in a segment of chromatin.The simulation demonstrated that the segment of chromatin shows the dynamic behaviour that its conformation can switch between a state with nearly all of the histones being wrapped by DNA and a state with nearly all of the histones being unwrapped by DNA,thus involving the "cross-talking" interactions among the histones.Each state can stay for a sufficiently long time.These conformational states are essential for gene expression or gene silence.The simulation also shows that these conformational states can be inherited by the daughter DNAs during DNA replication,giving a theoretical explanation of the epigenetic phenomenon. 相似文献
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