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F. T. Brandt G. Kramer Su-Long Nyeo 《Zeitschrift fur Physik C Particles and Fields》1990,48(2):301-308
We calculate cross sections for the production ofW + andZ bosons in association with 1 and 2 jets at \(p\bar p\) collider energies. The expected rates for these processes in second-order QCD are presented as a function of the cuts on the transverse momenta of the jets and are compared with jet rates measured by UA1. 相似文献
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Fahadul Islam Saikat Mitra Talha Bin Emran Zidan Khan Nikhil Nath Rajib Das Rohit Sharma Ahmed Abdullah Al Awadh Moon Nyeo Park Bonglee Kim 《Molecules (Basel, Switzerland)》2022,27(17)
Gastric cancer is one of the most common cancers of the gastrointestinal tract. Although surgery is the primary treatment, serious maladies that dissipate to other parts of the body may require chemotherapy. As there is no effective procedure to treat stomach cancer, natural small molecules are a current focus of research interest for the development of better therapeutics. Chemotherapy is usually used as a last resort for people with advanced stomach cancer. Anti-colon cancer chemotherapy has become increasingly effective due to drug resistance and sensitivity across a wide spectrum of drugs. Naturally-occurring substances have been widely acknowledged as an important project for discovering innovative medications, and many therapeutic pharmaceuticals are made from natural small molecules. Although the beneficial effects of natural products are as yet unknown, emerging data suggest that several natural small molecules could suppress the progression of stomach cancer. Therefore, the underlying mechanism of natural small molecules for pathways that are directly involved in the pathogenesis of cancerous diseases is reviewed in this article. Chemotherapy and molecularly-targeted drugs can provide hope to colon cancer patients. New discoveries could help in the fight against cancer, and future stomach cancer therapies will probably include molecularly formulated drugs. 相似文献
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Abdul Hawil Abas Siti Marfuah Rinaldi Idroes Diah Kusumawaty Fatimawali Moon Nyeo Park Abolghasem Siyadatpanah Fahad A. Alhumaydhi Shafi Mahmud Trina Ekawati Tallei Talha Bin Emran Bonglee Kim 《Molecules (Basel, Switzerland)》2022,27(7)
The coronavirus disease 2019 (COVID-19) pandemic is still ongoing, with no signs of abatement in sight. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of this pandemic and has claimed over 5 million lives, is still mutating, resulting in numerous variants. One of the newest variants is Omicron, which shows an increase in its transmissibility, but also reportedly reduces hospitalization rates and shows milder symptoms, such as in those who have been vaccinated. As a result, many believe that Omicron provides a natural vaccination, which is the first step toward ending the COVID-19 pandemic. Based on published research and scientific evidence, we review and discuss how the end of this pandemic is predicted to occur as a result of Omicron variants being surpassed in the community. In light of the findings of our research, we believe that it is most likely true that the Omicron variant is a natural way of vaccinating the masses and slowing the spread of this deadly pandemic. While the mutation that causes the Omicron variant is encouraging, subsequent mutations do not guarantee that the disease it causes will be less severe. As the virus continues to evolve, humans must constantly adapt by increasing their immunity through vaccination. 相似文献
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Soonbum Park Eun A Cho Jung Nyeo Chun Da Young Lee Sanghoon Lee Mi Yeon Kim Sang Mun Bae Su In Jo So Hee Lee Hyun Ho Park Tae Min Kim Insuk So Sang-Yeob Kim Ju-Hong Jeon 《Experimental & molecular medicine》2022,54(8):1225
Crizotinib is a clinically approved tyrosine kinase inhibitor for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring EML4-ALK fusion. Crizotinib was originally developed as an inhibitor of MET (HGF receptor), which is involved in the metastatic cascade. However, little is known about whether crizotinib inhibits tumor metastasis in NSCLC cells. In this study, we found that crizotinib suppressed TGFβ signaling by blocking Smad phosphorylation in an ALK/MET/RON/ROS1-independent manner in NSCLC cells. Molecular docking and in vitro enzyme activity assays showed that crizotinib directly inhibited the kinase activity of TGFβ receptor I through a competitive inhibition mode. Cell tracking, scratch wound, and transwell migration assays showed that crizotinib simultaneously inhibited TGFβ- and HGF-mediated NSCLC cell migration and invasion. In addition, in vivo bioluminescence imaging analysis showed that crizotinib suppressed the metastatic capacity of NSCLC cells. Our results demonstrate that crizotinib attenuates cancer metastasis by inhibiting TGFβ signaling in NSCLC cells. Therefore, our findings will help to advance our understanding of the anticancer action of crizotinib and provide insight into future clinical investigations.Subject terms: Non-small-cell lung cancer, Targeted therapies 相似文献
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Fei Yu Qi Wang Han Wang Long-Long Si Jia-Xin Liu Xu Han Su-Long Xiao Li-He Zhang De-Min Zhou 《中国化学快报》2016,27(5):711-713
A series of echinocystic acid (EA) 28-COOH derivatives was synthesized, and their anti-HCV entry activity was evaluated by HCVpp and VSVpp entry assay. It was found that some of them showed moderate anti-HCV entry activity, especially compound 12, and these modifications also removed the undesired hemolytic effect. 相似文献
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We consider, in the light-cone gauge, the possible structure of the counterterms arising in the solution to the renormalization equation. Using the structure of these counterterms and the noncovariant formalism of the integrals as guidelines, we also examine to one-loop order the divergence and nonlocality of theN-point gluon vertex functions forN≧5. 相似文献
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Su-Long Nyeo 《Zeitschrift fur Physik C Particles and Fields》1992,54(4):615-619
The background-field method is used to evaluate the logarithmic contributions to a nonlocal three-quark operator on the light-cone. The operator is composed of nonlocal operators of different spins, whose anomalous dimensions are obtained by choosing the Weyl representation for the Dirac matrices in the nonlocal results. The anomalous dimensions of the corresponding local three-quark operators calculated by conventional approaches are obtained by local expansion of the nonlocal results. 相似文献
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Md Rifat Hasan Ahad Amer Alsaiari Burhan Zain Fakhurji Mohammad Habibur Rahman Molla Amer H. Asseri Md Afsar Ahmed Sumon Moon Nyeo Park Foysal Ahammad Bonglee Kim 《Molecules (Basel, Switzerland)》2022,27(13)
The conventional drug discovery approach is an expensive and time-consuming process, but its limitations have been overcome with the help of mathematical modeling and computational drug design approaches. Previously, finding a small molecular candidate as a drug against a disease was very costly and required a long time to screen a compound against a specific target. The development of novel targets and small molecular candidates against different diseases including emerging and reemerging diseases remains a major concern and necessitates the development of novel therapeutic targets as well as drug candidates as early as possible. In this regard, computational and mathematical modeling approaches for drug development are advantageous due to their fastest predictive ability and cost-effectiveness features. Computer-aided drug design (CADD) techniques utilize different computer programs as well as mathematics formulas to comprehend the interaction of a target and drugs. Traditional methods to determine small-molecule candidates as a drug have several limitations, but CADD utilizes novel methods that require little time and accurately predict a compound against a specific disease with minimal cost. Therefore, this review aims to provide a brief insight into the mathematical modeling and computational approaches for identifying a novel target and small molecular candidates for curing a specific disease. The comprehensive review mainly focuses on biological target prediction, structure-based and ligand-based drug design methods, molecular docking, virtual screening, pharmacophore modeling, quantitative structure–activity relationship (QSAR) models, molecular dynamics simulation, and MM-GBSA/MM-PBSA approaches along with valuable database resources and tools for identifying novel targets and therapeutics against a disease. This review will help researchers in a way that may open the road for the development of effective drugs and preventative measures against a disease in the future as early as possible. 相似文献
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