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Aibrohim Dramae Sutichai Nithithanasilp Wilunda Choowong Pranee Rachtawee Samran Prabpai Palangpon Kongsaeree Pattama Pittayakhajonwut 《Tetrahedron》2013
Two new natural products, samroiyotmycins A (1) and B (2), along with two naturally new novclobiocin 101 (3) and 4-hydroxy-3-(3-methylbut-2-enyl)benzamide (5), and five known substances including neoantimycin, clorobiocin (4), 29-O-methylabierixin, daidzein, and 1-(3-indolyl)-2,3-dihydroxypropan-1-one have been isolated from Streptomyces sp. BCC33756. Their chemical structures were determined based on NMR spectral information and the relative stereochemistry of compound 1 was determined by X-ray crystallographic data. Both samroiyotmycins A and B exhibited antimalarial activity against Plasmodium falciparum K1—multi-drug resistant strain, with IC50 values of 3.65 and 3.16 μg/mL, respectively. Compound 1 was inactive against both cancerous (MCF-7, KB) and non-cancerous (Vero) cells, while compound 2 displayed cytotoxicity against Vero cell with IC50 value of 29.57 μg/mL. 相似文献
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Masahiko Isaka Somporn Palasarn Wilunda Choowong Suchada Mongkolsamrit 《Tetrahedron letters》2019,60(2):154-156
Conoideoxime A (1), a prenyl-tryptophan dimer possessing bis-oxime functionality, was isolated from cultures of the whitefly pathogenic fungus Conoideocrella luteorostrata BCC 76664. The structure was elucidated by spectroscopic analyses. It displayed antibacterial activity against Gram-positive bacteria, Bacillus cereus, Enterococcus faecium, and Staphylococcus aureus, with MIC values of 3.13, 6.25, and 6.25?μg/mL, respectively. 相似文献
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Lanostane triterpenoids from cultivated fruiting bodies of the basidiomycete Ganoderma australe 总被引:1,自引:0,他引:1
Masahiko Isaka Panida Chinthanom Sermsiri Mayteeworakoon Kobkul Laoteng Wilunda Choowong Rattaket Choeyklin 《Natural product research》2018,32(9):1044-1049
A new lanostane triterpene (1), together with three known compounds (2–4), were isolated from cultivated fruiting bodies of the basidiomycete Ganoderma australe. The structure was elucidated on the basis of NMR spectroscopic and mass spectrometry data. The olefinic geometry of methyl australate (2) was revised from 20(22)Z to 20(22)E. These compounds (1–4) were different from the lanostanes isolated from mycelial cultures of the same strain source. 相似文献
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Seangaroon Yoiprommarat Surisa Kongthong Wilunda Choowong Nattawut Boonyuen Masahiko Isaka 《Natural product research》2020,34(9):1233-1237
AbstractFour xanthones (1?4) and a known compound, mansonone D (5), were isolated from the lignicolous freshwater fungus BCC 28210 (family, Chaetosphaeriaceae). The structures of these compounds were elucidated by extensive spectroscopic analysis. Among the isolated metabolites, compound 2 and the known mansonone D (5) displayed antimalarial activity against Plasmodium falciparum K1 with IC50 values of 7.75 and 0.55?μg/mL, respectively. Compound 4 displayed antibacterial activity against Bacillus cereus with an MIC value of 6.25?μg/mL. 相似文献
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Berkleasmins A-E, five new eremophilane sesquiterpenoids were isolated from the saprobic fungus Berkleasmium nigroapicale BCC 8220. The structures of the new compounds were elucidated by analyses of NMR spectroscopic and mass spectrometry data in combination with chemical means. Berkleasmins A and C exhibited cytotoxic activity against cancer cell-lines (NCI-H187, MCF-7, and KB) as well as nonmalignant Vero cells with IC50 values of 1.1-7.5 μg/mL, and these compounds also showed antimalarial activity with respective IC50 of 3.1 and 2.8 μg/mL. 相似文献
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Sterostreins A-E (1, 2, 3a/3b, 4, and 5), five novel terpenoids, were isolated from cultures of the mushroom fungus Stereum ostrea BCC 22955. Sterostrein A (1) exhibited antimalarial activity (IC(50) 2.3 μg/mL) and cytotoxicity (IC(50) 5.3-38 μg/mL). 相似文献
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Masahiko Isaka Rachada HaritakunSumalee Supothina Wilunda ChoowongSuchada Mongkolsamrit 《Tetrahedron》2014
Six new compounds, an N-hydroxypyridone glucoside, orbiocrellin A (1), its aglycone orbiocrellin B (2), chromone glucosides 3 and 4, a dihydrochromone 5a/5b, and a chromone 6, were isolated from the scale-insect pathogenic fungus Orbiocrella sp. BCC 33248. Orbiocrellin A (1) exhibited antimalarial activity against Plasmodium falciparum K1 (IC50 3.1 μg/mL) while it was non-cytotoxic. In contrast, orbiocrellin B (2) showed both antimalarial (IC50 2.1 μg/mL) and cytotoxic (NCI-H187 cells, IC50 0.70 μg/mL) activities. 相似文献
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The nature of the surface species on Pt/Al2O3 for the SCR of NO by C3H6 under excess oxygen has been investigated. An experiment consisting of three steps shows that there are at least three types
of surface species occurring on the catalyst surface. However, a reactivity test and an investigation of surface species after
adding a second metal (Fe, Sn, Co, Cr or W) to Pt/Al2O3 indicate that only (ClHmOn)HT species play an important role in NO reduction at a low operating temperature.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
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