Improved sample preparation method for environmental plutonium analysis by ICP-SFMS and alpha-spectrometry

A rapid and simple sample preparation method for plutonium determination in environmental samples by inductively coupled plasma sector field mass spectrometry (ICP-SFMS) and alpha-spectrometry is described. The developed procedure involves a selective CaF₂ co-precipitation for preconcentration followed by extraction chromatographic separation. The proposed method effectively eliminates the possible interferences in mass spectrometric analysis and also removes interfering radionuclides that may disturb alpha-spectrometric measurement. For ²³⁹Pu, ²⁴⁰Pu and ²⁴¹Pu limits of detection of 9.0 fg·g⁻¹ (0.021 mBq), 1.7 fg·g⁻¹ (0.014 mBq) and 3.1 fg·g⁻¹ (11.9 mBq) were achieved by ICP-SFMS, respectively, and 0.02 mBq by alpha-spectrometry. Results of certified reference materials agreed well with the recommended values.     

Angiotensin converting enzyme inhibitors/cyclodextrin inclusion complexes: solution and solid-state characterizations and their thermal stability

Angiotensin converting enzyme (ACE) inhibitors have recently gained attention as a new class of drug in the therapeutic management of glaucoma. However, the application of eye drops is limited because of their chemical instability in aqueous solutions. To overcome such a problem, cyclodextrins (CDs) were introduced to form inclusion complexes. Three ACE inhibitors, namely, captopril, quinapril and fosinopril (FOS), were chosen and the effect of CDs on their thermal stability in aqueous solutions was investigated. All three drugs formed inclusion complexes of 1:1 stoichiometry with all three natural CDs and the FOS/γCD inclusion complex possessed the highest stability constant, resulting in thermal stability enhancement. Furthermore, the addition of antioxidants could greatly enhance the thermal stability of FOS in the presence of γCD in aqueous solutions. The inclusion complex formation of FOS/γCD was further examined by computational and experimental characterizations. All these characterization results confirmed that FOS and γCD formed a true inclusion complex that provided drug stabilization in the aqueous eye drop medium.

     

Measurements of γ-γ and γ-electron directional correlations in119Sb

The directional correlations ofγ-γ andγ-electron cascades in¹¹⁹Sb are measured, in the decay of^119mTe. Bothγ-γ andγ-electron directional correlation coefficients are determined for the cascades (energies in keV): 153.5-1212.7, 942.3-270.5, (976.2+979.3)-270.5, 1095.7-270.5 and 1136.8-270.5. For the cascades 912.6-1366.2, 2013.4-270.5 and 2089.9-270.5γ-γ directional correlations are measured. The mixing ratios evaluated are:δ(M2/E1, 153.5 keV)=0.0003±0.0023,δ(E2/M1, 270.5 keV)=-0.39±0.29,δ(E2/M1, 942.3 keV)= ?0.26±0.12,δ(E3/M2,1095.7 keV)=?0.01±0.07, andδ(M3/E2,1212.7 keV) =0.004±0.007. The result is compared with theoretical predictions.     

Characterizing properties of approximate solutions for optimization problems

Approximate solutions for optimization problems become of interest if the ‘true’ optimum cannot be found: this may happen for the simple reason that an optimum does not exist or because of the ‘bounded rationality’ (or bounded accuracy) of the optimizer. This paper characterizes several approximate solutions by means of consistency and additional requirements. In particular we consider invariance properties. We prove that, where the domain contains optimization problems without maximum, there is no non-trivial consistent solution satisfying non-emptiness, translation and multiplication invariance. Moreover, we show that the class of ‘satisficing’ solutions is obtained, if the invariance axioms are replaced with Chernoff’s Choice Axiom.     

Dexamethasone delivery to posterior segment of the eye

Due to anatomic barriers and lacrimal drainage it is difficult to obtain therapeutic drug concentrations in the posterior part of the eye after topical drug administrations. Lipophilic cyclodextrins, such as randomly methylated β-cyclodextrin (RMβCD), are known to act both as solubilizers of water-insoluble drugs in aqueous solutions and as penetration enhancers that reduce the barrier function of lipophilic membranes. The purpose of this study was to investigate the effects of RMβCD on dexamethasone delivery from aqueous eye drop solution into rabbit eyes. Dexamethasone (0.5 and 1.5% w/v) drops (50 μl) were administered to the left eye of rabbits (n = 6) and the drug levels measured in different eye tissues 2 h after administration. In aqueous humor dexamethasone levels were 1,190 ± 110 and 1,670 ± 630 ng/g (mean ± SD) after administration of the 0.5 and 1.5% dexamethasone eye drops, respectively. In the retina the levels were 33 ± 7 and 66 ± 49 ng/g, and in optic nerve 41 ± 12 and 130 ± 50 ng/g, respectively. In a previous study the dexamethasone concentration in aqueous humor after topical administration of 1.3% (w/v) dexamethasone eye drops in aqueous 2-hydroxypropyl-β-cyclodextrin (HPβCD) solution was determined to be 320 ± 230 ng/g and 66 ± 20 ng/g after administration of Maxidex^® eye drops. Both the hydrophilic HPβCD and the lipophilic RMβCD enhance topical dexamethasone delivery into the eye, but of the two, the lipophilic RMβCD results in higher dexamethasone concentrations.     

Traveling salesman games

In this paper we discuss the problem of how to divide the total cost of a round trip along several institutes among the institutes visited. We introduce two types of cooperative games—fixed-route traveling salesman games and traveling salesman games—as a tool to attack this problem. Under very mild conditions we prove that fixed-route traveling salesman games have non-empty cores if the fixed route is a solution of the classical traveling salesman problem. Core elements provide us with fair cost allocations. A traveling salesman game may have an empty core, even if the cost matrix satisfies the triangle inequality. In this paper we introduce a class of matrices defining TS-games with non-empty cores.     

Additive stable solutions on perfect cones of cooperative games

Closed kernel systems of the coalition matrix turn out to correspond to cones of games on which the core correspondence is additive and on which the related barycentric solution is additive, stable and continuous. Different perfect cones corresponding to closed kernel systems are described. Received: December 2001/Revised: July 2002 RID="*" ID="*"  This note contains the new results, which were presented by the first author in an invited lecture at the XIV Italian Meeting on Game Theory and Applications in Ischia, July 2001. The lecture was dedicated to Irinel Dragan on the occasion of his seventieth birthday.     

Accumulation of uranium, transuranium and fission products on stainless steel surfaces II. Sorption studies in a laboratory model system

Within the frame of a joint project, the accumulation of the uranium and transuranium (TRU) species on some structural materials used at Soviet made VVER-type pressurized water reactors (such as heat exchanger tube of steam generators and stainless steel canister material) has been studied. The experiments were carried out in a laboratory model system. During the sorption studies, boric acid coolants provided by the Paks Nuclear Power Plant (Paks NPP) were circulated for a period of 30 h. Solution and tube samples obtained in the course of above experiments were analyzed by independent methods (??- and ??-spectrometry, ICP-MS, SEM-EDX, voltammetry and XPS). The experimental results reveal that: (i) the surface excess of the TRU nuclides studied is extremely low (less than 1% of a monolayer coverage); (ii) the surface excess of uranium species measured on the SG tube surfaces is significantly higher, after 30 h sorption period (??_sample = 1.0 ??g cm^?2 U ? 3.7 × 10^?9 mol cm^?2 UO₂) exceeds a monolayer coverage; (iii) the mechanistic features of the contamination processes (specific or non-specific adsorption, deposition of colloidal and/or disperse particles) depend decisively upon the nature of the studied radionuclides and the chemical structure and composition of the oxide layer formed on stainless steel surfaces.