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Grigor’ev Arthur A. Kayukov Yakov S. Nikiforova Anastasiya L. Karpov Sergey V. Shchegravina Ekaterina S. Kayukova Olga V. Tafeenko Victor A. 《Chemistry of Heterocyclic Compounds》2019,55(2):167-171
Chemistry of Heterocyclic Compounds - 4-Acyl-2-amino-6-chloropyridine-3,5-dicarbonitriles underwent heterocyclization in the presence of ammonia in aqueous dioxane medium, involving the... 相似文献
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Mol’kova E. A. Shchegravina E. S. Otvagin V. F. Kuzmina N. S. Malysheva Yu. B. Svirshchevskaya E. V. Zaburdaeva E. A. Fedorov A. Yu. 《Russian Chemical Bulletin》2022,71(3):564-571
Russian Chemical Bulletin - A series of colchicine and thiocolchicine derivatives bearing a Michael acceptor moiety in ring A were synthesized. Some of these compounds exhibit cytotoxic activity in... 相似文献
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N. S. Sitnikov A. V. Sintsov E. S. Shchegravina A. Prokop H. G. Schmalz V. V. Fokin A. Yu. Fedorov 《Russian Chemical Bulletin》2015,64(6):1362-1368
The cycloaddition of acetylene derivatives of azido-substituted pyrroloallocolchicines afforded 7-(triazol-1-yl)pyrroloallocolchicines. The synthesized compounds exhibit considerable cytotoxicity and apoptosis-inducing activity against Nalm 6 human leukemia cells. 相似文献
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Anahid Saneei Mehrdad Pourayoubi Titus A. Jenny Aurelien Crochet Katharina M. Fromm Ekaterina S. Shchegravina 《Chemical Papers》2017,71(10):1809-1823
Different molecular assemblies were compared in two new structures [4-CH3-C6H4C(O)NH]P(O)[NH]2(CH2)3, 1, and [4-CH3-C6H4C(O)NH]P(O)[NHC6H3(3,4-CH3)2]2, 2, belonging to the families of “cyclic phosphoric triamide” and “phosphoric triamide”, respectively. The differences in the hydrogen bond motifs were discussed (by single crystal X-ray diffraction) as a result of three factors: (1) action of two N atoms with a non-planar environment in 1 as an H-bond acceptor, (2) different orientations of three N–H bond vectors in two molecules and (3) different conformations of C=O and P=O groups. These differences lead to more complicated hydrogen bond pattern of 1, with respect to that of 2, as structure 1 may be considered as a model of four-acceptor–three-donor versus a two-acceptor–three-donor system in 2. The main discrepancies of 1 and 2, monitored by the Hirshfeld surface analysis, are related to the contribution portions of O···H/H···O contacts, in which compound 1 not only involves the greater existence of classical hydrogen bonds but also contains the further C–H···O weak interactions in its crystal packing with respect to compound 2. Instead, in 2, the shortage of O···H/H···O contacts has been partially compensated by the C···H/H···C interactions, due to the presence of more unsaturated carbon acceptors. The differences in assemblies are also reflected in the solid-state IR spectra, especially for the N–H vibration frequencies. The new compounds were further studied by 1D NMR experiments (1H, 13C, 31P), 2D NMR techniques [HMQC and HMBC (H–C correlation), HSQC (N–H correlation)], high-resolution ESI–MS, EI–MS spectrometry and IR spectroscopy. 相似文献
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A. S. Zotov E. S. Shchegravina A. Yu. Fedorov 《Russian Journal of Organic Chemistry》2018,54(10):1498-1504
Conjugates of allocolchicine and a cetirizine analog have been synthesized as potential anti-inflammatory and anti-allergic drugs. 相似文献
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