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1.
Arijit BanerjeeSamir Kumar Maji Michael G.B. DrewDebasish Haldar Arindam Banerjee 《Tetrahedron letters》2003,44(4):699-702
A single-crystal X-ray diffraction study of the terminally protected tetrapeptide Boc-β-Ala-Aib-Leu-Aib-OMe 1 (Aib: α-aminoisobutyric acid; β-Ala: β-Alanine) reveals that it adopts a new type of double turn structure which self-associates to form a unique supramolecular helix through intermolecular hydrogen bonds. Scanning electron microscopic studies show that peptide 1 exhibits amyloid-like fibrillar morphology in the solid state. 相似文献
2.
Joseph T. Repine Douglas S. Johnson Andrew D. White Michael A. Stier Trent Rankin Samarendra N. Maiti 《Tetrahedron letters》2007,48(31):5539-5541
A series of regioisomerically monofluorinated 1-(naphthalen-1-yl)piperazines is described. 相似文献
3.
Indole-2-yl-prop-2-ynyl sulfides, under thiophenol-mediated alkenyl radical cyclization conditions, afforded exclusively 4-thiophenyl-2,3,4,9-tetrahydrothiopyrano[2,3-b]indoles or 3-thiophenylmethyl-2,3,8-trihydrothieno[2,3-b]indoles depending on the substituent at the indole nitrogen. 相似文献
4.
Andhe V. Narender Reddy Charles Y. Fiakpui David P. Czajkowski Paul Spevak Jadwiga Kaleta Ronald G. Micetich Samarendra N. Maiti 《Chemistry of Heterocyclic Compounds》1998,34(11):1289-1295
A new series of 2-spiro(2,2-diphenylcyclopropane) cephalosporin sulfones was synthesizes as potent human leukocyte elastase inhibitors.SynPhar Laboratories Inc., #2 Taiho Alberta Centre, 4290-91A Street, Edmonton, Canada T6R 5V2. Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1517–1523, November, 1998. 相似文献
5.
Oludotun A. Phillips Eduardo L. Setti Andhe V. N. Reddy Ronald G. Micetich Chieko Kunugita Akio Hyodo Samarendra N. Maiti 《Chemistry of Heterocyclic Compounds》1998,34(11):1319-1323
Two monobactam derivatives, potassium 4-methyl-(3E)-[(thien-2-yl)methylene]-2-azetidinone-1-sulfonate and its (3Z)-isomer, were prepared and evaluated for their -lactamase inhibitory activities. These compounds were devoid of -lactamase inhibitory activity.SynPhar Laboratories Inc., #2, 4290-91A Street, Edmonton, Alberta T6E 5V2, Canada. Tokushima Research Institute, Taiho Pharmaceutical Co., Ltd., 224-2 Ebisuno Hiraishi, Kawauchi-cho, Tokushima 771-01, Japan. Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1548–1552, November, 1998. 相似文献
6.
Chloramphenicol and thiamphenicol have been enantioselectively synthesized using an asymmetric halohydrin reaction as a key step. In particular, halomethoxylation reaction was used, where O-methyl functions as a hydroxyl protecting group and eliminates an additional protection step. 相似文献
7.
With the advent of single-cell RNA-sequencing (scRNA-seq), it is possible to measure the expression dynamics of genes at the single-cell level. Through scRNA-seq, a huge amount of expression data for several thousand(s) of genes over million(s) of cells are generated in a single experiment. Differential expression analysis is the primary downstream analysis of such data to identify gene markers for cell type detection and also provide inputs to other secondary analyses. Many statistical approaches for differential expression analysis have been reported in the literature. Therefore, we critically discuss the underlying statistical principles of the approaches and distinctly divide them into six major classes, i.e., generalized linear, generalized additive, Hurdle, mixture models, two-class parametric, and non-parametric approaches. We also succinctly discuss the limitations that are specific to each class of approaches, and how they are addressed by other subsequent classes of approach. A number of challenges are identified in this study that must be addressed to develop the next class of innovative approaches. Furthermore, we also emphasize the methodological challenges involved in differential expression analysis of scRNA-seq data that researchers must address to draw maximum benefit from this recent single-cell technology. This study will serve as a guide to genome researchers and experimental biologists to objectively select options for their analysis. 相似文献
8.
Subhajit Laha Nimish Dwarkanath Abhishek Sharma Darsi Rambabu Sundaram Balasubramanian Tapas Kumar Maji 《Chemical science》2022,13(24):7172
Light hydrocarbon separation is considered one of the most industrially challenging and desired chemical separation processes and is highly essential in polymer and chemical industries. Among them, separating ethylene (C2H4) from C2 hydrocarbon mixtures such as ethane (C2H6), acetylene (C2H2), and other natural gas elements (CO2, CH4) is of paramount importance and poses significant difficulty. We demonstrate such separations using an Al-MOF synthesised earlier as a non-porous material, but herein endowed with hierarchical porosity created under microwave conditions in an equimolar water/ethanol solution. The material possessing a large surface area (793 m2 g−1) exhibits an excellent uptake capacity for major industrial hydrocarbons in the order of C2H2 > C2H6 > CO2 > C2H4 > CH4 under ambient conditions. It shows an outstanding dynamic breakthrough separation of ethylene (C2H4) not only for a binary mixture (C2H6/C2H4) but also for a quaternary combination (C2H4/C2H6/C2H2/CO2 and C2H4/C2H6/C2H2/CH4) of varying concentrations. The detailed separation/purification mechanism was unveiled by gas adsorption isotherms, mixed-gas adsorption calculations, selectivity estimations, advanced computer simulations such as density functional theory (DFT), grand canonical Monte Carlo (GCMC) and ab initio molecular dynamics (AIMD), and stepwise multicomponent dynamic breakthrough experiments.Industrially important C2H4 purification from multi-component hydrocarbon mixtures. 相似文献
9.
Dr. Papri Sutar Dr. Vasudeva Rao Bakuru Pooja Yadav Subhajit Laha Dr. Suresh Babu Kalidindi Prof. Dr. Tapas Kumar Maji 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(10):3268-3272
The composite hydrogel of a nanoscale metal–organic framework (NMOF) and nanoclay has emerged as a new soft-material with advanced properties and applications. Herein, we report a facile synthesis of a hydrogel nanocomposite by charge-assisted self-assembly of Pd@ZIF-8 nanoparticles with Laponite® nanoclay which coat the surface of Pd@ZIF-8 nanoparticles. Such surface coating significantly enhanced the thermal stability of the ZIF-8 compared to the pristine framework. Further, the Pd@ZIF-8+LP hydrogel nanocomposite shows better size-selective catalytic hydrogenation of olefins than Pd@ZIF-8 nanoparticles based on selective diffusion of the substrate. 相似文献
10.