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Ravula Sharada Nukala Satheesh Kumar Thirukovela Narasimha Swamy Sirassu Narsimha Dasari Gouthami Kurma Srimathi Bandari Srinivas 《Russian Journal of General Chemistry》2022,92(4):702-708
Russian Journal of General Chemistry - In the current study, some new quinoxaline linked 1,3,4-oxadiazole sulfonamide hybrids have been designed, synthesized and characterized by IR, 1H and 13C... 相似文献
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Sreerama Rakesh Kumar N. Manoj Nukala Satheesh Kumar Sucharitha E. Ramya Babu H. Ramesh Narsimha Sirassu 《Russian Journal of General Chemistry》2021,91(12):2515-2521
Russian Journal of General Chemistry - This study is devoted to the efficient and practical synthesis of a novel series of pyrido[4,3-d]pyrimidine derivatives attached to 1,2,3-triazole ring and... 相似文献
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Kurma Srimathi Dasari Gouthami Nukala Satheesh Kumar Ravula Sharada Kandukuri Padma Bandari Srinivas 《Russian Journal of General Chemistry》2022,92(7):1326-1332
Russian Journal of General Chemistry - A series of new quinoxaline-1,2,4-thiadiazoles amide hybrids has been synthesized and evaluated for their anti-proliferative activity on four different human... 相似文献
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Sirassu Narsimha Sathesh Kumar Nukala T. Savitha Jyostna M. Ravinder M. Srinivasa Rao N. Vasudeva Reddy 《Journal of heterocyclic chemistry》2020,57(4):1655-1665
In search of better antibacterial and anticancer agents, a series of novel 4-[3-fluoro-4-(morpholin-4-yl)]phenyl-1H-1,2,3-triazole derivatives were synthesized ( 6a - l and 8a - j ) by using 3-fluoro-4-morpholinoaniline, alkyne, and triflyl azide via an in situ generated 4-(4-azido-2-fluorophenyl)morpholine and evaluated for their antibacterial and anticancer activity in vitro. Antibacterial activity against three G+ bacterial strains and anticancer activity against breast cancer cell line (MCF-7) and cervical carcinoma cell line (HeLa) was evaluated. Among all the tested compounds, 6h , 6i , and 8b exhibited potent antibacterial activity against tested gram-positive bacterial strains. The anticancer activity screening results of 8f , 8h , and 8i exhibited potent cytotoxic activity against two cancer cell lines with IC50 values nearer to the standard drug, doxorubicin. The remaining compounds have shown good to moderate activity against the tested cell lines. On the basis of the results obtained, a structure-activity relationship (SAR) is discussed. 相似文献
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Nukala P. K. V. V. Simunovic S. 《The European Physical Journal B - Condensed Matter and Complex Systems》2004,37(1):91-100
The European Physical Journal B - This paper presents two main results. The first result indicates that in materials with broadly distributed microscopic heterogeneities, the fracture strength... 相似文献
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G. Frantziskonis K. Muralidharan P. Deymier S. Simunovic P. Nukala S. Pannala 《Journal of computational physics》2009,228(21):8085-8092
We introduce the time-parallel compound wavelet matrix method (tpCWM) for modeling the temporal evolution of multiscale and multiphysics systems. The method couples time parallel (TP) and CWM methods operating at different spatial and temporal scales. We demonstrate the efficiency of our approach on two examples: a chemical reaction kinetic system and a non-linear predator–prey system. Our results indicate that the tpCWM technique is capable of accelerating time-to-solution by 2–3-orders of magnitude and is amenable to efficient parallel implementation. 相似文献
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AbstractA new and practical method has been developed for the synthesis of 2,4-disubstituted quinolines via one-pot three-component reaction of o-amino arylketones, aldehydes and ammonium acetate in high yields by using DDQ in CH3CN under mild conditions. Neutral conditions, atom economy, easy work-up procedures and compatible with different functional groups are the salient features of this protocol. 相似文献
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Badithapuram Vinitha Nukala Satheesh Kumar Thirukovela Narasimha Swamy Manchal Ravinder Dasari Gouthami Bandari Srinivas 《Russian Journal of General Chemistry》2022,92(1):117-124
Russian Journal of General Chemistry - Herein, synthesis of some new quinoxaline-1,2,4-oxadiazole derivatives is presented, and their in vitro anti-cancer activity against four human cancer cell... 相似文献