A short synthesis of (±)-tecomanine via a Pauson-Khand-based route

The N-carboethoxy precursor to (±)-tecomanine has been prepared in 11 steps from 2-methyl-1-buten-3-yne. The key step, Pauson-Khand cyclization of a methylated 5-aza-6-nonen-1-yne succeeds, but only in low yield, a consequence of the dialkyl substitution about the azaenyne framework. Nevertheless, the overall sequence to that point is one of the more efficient to be described.     

Unified nomenclature for chromatography

The background of the new Unified Nomenclature for Chromatography just accepted by the International Union of Pure and Applied Chemistry (IUPAC) is explained and selected highlights of the new rules are elaborated.     

Growth of masking as a measure of response growth in hearing-impaired listeners

Growth-of-masking functions were obtained from 19 normal and 5 hearing-impaired listeners using a simultaneous-masking paradigm. When masker and probe frequency are identical, the slope of masking approximates 1.0 for both normal-hearing and impaired listeners. For masker frequencies less than or greater than probe frequency, the slopes for impaired listeners are shallower than those of normals. These findings are consistent with previously reported physiological data (single-fiber rate versus level and AP masking functions) for animals with induced cochlear lesions. Results are discussed in terms of a potential masking technique to estimate the growth of response in normal and impaired ears.     

Metaheuristics can solve sudoku puzzles

In this paper we present, to our knowledge, the first application of a metaheuristic technique to the very popular and NP-complete puzzle known as ‘sudoku’. We see that this stochastic search-based algorithm, which uses simulated annealing, is able to complete logic-solvable puzzle-instances that feature daily in many of the UK’s national newspapers. We also introduce a new method for producing sudoku problem instances (that are not necessarily logic-solvable) and use this together with the proposed SA algorithm to try and discover for what types of instances this algorithm is best suited. Consequently we notice the presence of an ‘easy-hard-easy’ style phase-transition similar to other problems encountered in operational research.     

A transportable gamma spectroscopy system applied to the measurement of fission products

Normally, gamma-ray spectroscopy is performed by equipment positioned in the SLOWPOKE-2 Facility at the Royal Military College; however, there have occasionally been requirements for analyses externally. A transportable gamma spectroscopy system was thus assembled by acquiring a commercially available multichannel analyzer, analysis program and detector, and by designing and constructing a transportable shielding castle. It was then used to take measurements of fission product concentrations at several research reactors.     

Current methods for site-directed structure generation

Summary There has been a rapid growth of interest in techniques for site-directed drug design, fuelled by the increasing availability of structural models of proteins of therapeutic importance, and by studies reported in the literature showing that potent chemical leads can be obtained by these techniques. Structure generation programs offer the prospect of discovering highly original lead structures from novel chemical families. Due to the fact that this technique is more-or-less still in its infancy, there are no case studies available that demonstrate the use of structure generation programs for site-directed drug design. Such programs were first proposed in 1986, and became commercially available in early 1992. They have shown their ability to reproduce, or suggest reasonable alternatives for, ligands in well-defined binding sites. This brief review will discuss the recent advances that have been made in the field of site-directed structure generation.     

Investigation of the reaction order for nucleophilic substitution of dialkyl methylphosphonates by alkoxides

The rate of nucleophilic substitution at the phosphorus centre of dialkyl methylphosphonates by methoxide and ethoxide has been studied to investigate the possible involvement of hexacoordinated phosphorus species in this reaction. For alkoxide concentrations less than ca. 1.5 M the rate increases with the square of alkoxide concentration. However, consideration of the activity of the alkoxides, represented by an appropriate acidity function, reveals that only one equivalent of alkoxide is involved in the rate-determining step. Thus, there is no requirement to invoke the intermediacy of a hexacoordinated species in the reaction pathway. © John Wiley & Sons, Inc.     

Partially finite convex programming,Part I: Quasi relative interiors and duality theory

We study convex programs that involve the minimization of a convex function over a convex subset of a topological vector space, subject to a finite number of linear inequalities. We develop the notion of the quasi relative interior of a convex set, an extension of the relative interior in finite dimensions. We use this idea in a constraint qualification for a fundamental Fenchel duality result, and then deduce duality results for these problems despite the almost invariable failure of the standard Slater condition. Part II of this work studies applications to more concrete models, whose dual problems are often finite-dimensional and computationally tractable.     

Optimally Dense Packings of Hyperbolic Space

In previous work, a probabilistic approach to controlling difficulties of density in hyperbolic space led to a workable notion of optimal density for packings of bodies. In this paper we extend an ergodic theorem of Nevo to provide an appropriate definition of those packings to be considered optimally dense. Examples are given to illustrate various aspects of the density problem, in particular the shift in emphasis from the analysis of individual packings to spaces of packings.