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A solution of trifluoromethyl copper complex in hexamethylphosphoric triamide was found to be useful for trifluoromethylation of aliphatic halides. 相似文献
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Yoshiro Kobayashi Takaharu Nakano Masahura Nakajima Itsumaro Kumadaki 《Tetrahedron letters》1981,22(12):1113-1114
A new valence-bond isomer of pentakis(trifluoromethyl)-1,3-diazepine was synthesized from tris(trifluoromethyl)cyclopropenyl trifluoromethyl ketone, and reacted with diazomethane to give an N-methylated product. 相似文献
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Sato K Yamazoe S Yamamoto R Ohata S Tarui A Omote M Kumadaki I Ando A 《Organic letters》2008,10(12):2405-2408
1,3-Diketones were synthesized from alpha,beta-unsaturated ketones by treatment with acid chlorides and Et(2)Zn in the presence of RhCl(PPh(3))3. This is a very simple and extremely chemoselective reaction to give the adduct at the alpha-position of alpha,beta-unsaturated ketones. 相似文献
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Reduction of perfluoroalkyl ketones with chiral lithium alkoxides gave chiral α-perfluoroalkyl alcohols in high enantiomeric excesses. Interestingly, reaction of 2,2,2-trifluoroacetophenone (1) with lithium (S)-1-phenylethoxide (2) gave (S)-2,2,2-trifluoro-1-phenylethanol (3), while the same reaction of perfluorooctan-1-one (7) with 2 gave (R)-1H-1-phenylperfluorooctanol (8). Based on the speculation of mechanism, the order of steric effects on this reaction is estimated as C7F15 > substituted phenyl > CF3. 相似文献
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The reaction of tert-butyl N-(2-bromophenyl)carbamate (1) with ethyl perfluorooctanoate in the presence of tert-butyllithium did not give the desired N-(2-perfluorooctanoylphenyl)carbamate (3) but gave 1-hydroxy-1H-perfluorooctyl compound (4), which was supposed to be formed by the reduction of 3. A similar reaction of 2,2,2-trifluoroacetophenone with tert-butyllithium did not gave any reduction product. Detailed investigation showed that lithium ethoxide worked as the reducing agent of this abnormal reduction. By the reaction of lithium isopropoxide, an aldol product from 2,2,2-trifluoroacetophenone with acetone was isolated, while perfluoroheptyl or perfluoropropyl phenyl ketones were reduced by this alkoxide in a high yield without formation of the aldol adduct. 相似文献
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Fluorine diluted with argon was bubbled into a suspension of uracil in acetic acid at room temperature. Treatment of the reaction mixtur with alcohols gave 5-fluoro-6-alkoxy-5,6-dihydrouracils, which lost alcohols on sublimation under vacuum to give 5-fluorouracil quantitatively. 相似文献
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Yoshiro Kobayashi Takaharu Nakano Kazuharu Shirahashi Akira Takeda Itsumaro Kumadaki 《Tetrahedron letters》1980,21(48):4615-4618
The title cyclopropenylketone reacts with azo compounds and tri-phenylphosphine to give unique heterocycles; tricyclourazoles and a diazaoxacyclooctatriene. The formers were converted into a pyridazine. 相似文献