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排序方式: 共有72条查询结果,搜索用时 15 毫秒
1.
Yingyongnarongkul BE How SE Díaz-Mochón JJ Muzerelle M Bradley M 《Combinatorial chemistry & high throughput screening》2003,6(7):577-587
Advances in high throughput screening (HTS), together with the rapid progress in combinatorial chemistry, genomic and proteomic sciences have dramatically stimulated the development of a variety tools to enable the drug discovery process to become more efficient. Major future challenges in HTS include obtaining high density and good quality data based on assays that are rapid, reliable, inexpensive, sensitive, simple and miniaturised. This paper reviews the development and role of bead-based assays for HTS including DNA and single nucleotide polymorphism (SNP) assays, particularly from a multiplex perspective and evaluating the recent advances in bead-based arrays. The encoding strategies that are commonly used in bead-based assays are highlighted, while the importance of magnetic beads in genomic and proteomic purifications is discussed. In conclusion, bead-based assays offer a powerful promising approach for many aspects of drug discovery. 相似文献
2.
3.
Bor Yuan Lin Moo Been Chang Hsin Liang Chen How Ming Lee Sheng Jen Yu Shou Nan Li 《Plasma Chemistry and Plasma Processing》2011,31(4):585-594
The feasibility of C3F8 abatement via combining nonthermal plasma with adsorption and/or catalysis is investigated in this study. In terms of the simultaneous combination of plasma, adsorption and catalysis (CPAC), three different configurations including A/C layer (adsorbent layer prior to catalyst layer), C/A layer (catalyst layer prior to adsorbent layer) and A/C mixture (adsorbent and catalyst are mechanically mixed) are adopted. For all the experimental tests conducted in this study, the gas stream consists of 500 ppm C3F8, 2% O2, and balanced N2. The experimental results indicate that C3F8 removal efficiencies depend on what kind of packing material is adopted (adsorbent, catalyst or both) and how the material is packed within the plasma reactor. The removal efficiencies obtained with different reactors are in the order as: CPAC (A/C layer; AC mixture) > CPA (plasma with adsorbent alone) > CPC (plasma with catalyst alone) > CPAC (C/A layer). The indentified products after treatment include CO2, CO, N2O and CF4. The formation of C2F6 is not observed in this study, which is encouraging since the global warming potential of C2F6 is actually higher than that of C3F8. 相似文献
4.
Heng Huat Chan Elisavet Konstantinou Aristides Kontogeorgis Chik How Tan 《Finite Fields and Their Applications》2012,18(6):1232-1241
In this article, Ramanujan–Weber class invariants and its analogue are used to derive birthday elliptic curves. 相似文献
5.
Mu‐Huan Chi Chun‐Hsien Su Ming‐Hsiang Cheng Pei‐Yun Chung Chi‐How Peng Jiun‐Tai Chen 《Macromolecular rapid communications》2016,37(24):2037-2044
To manipulate the functions of nanomaterials more precisely for diverse applications, the controllability and critical influencing factors of their properties must be thoroughly investigated. In this work, the macroscopic and microscopic effects are studied on the photophysical properties of various pyrene‐ended poly(styrene‐block‐methyl methacrylate) nanostructures. Fluorescent polymer nanospheres, nanorods, and nanotubes are prepared by different template‐based methods using anodic aluminum oxide membranes. Chain arrangements and conformations are determined as the key factors affecting the photophysical properties of the fluorescent polymer nanostructures. This work not only gives a deeper understanding of the effects on the photophysical properties of polymer nanomaterials influenced by morphologies, chain arrangements, and chain conformations, but also provides a reference for designing proper fluorescent nanostructures for specific applications.
6.
How 《Fresenius' Journal of Analytical Chemistry》1870,9(1):382-383
Ohne Zusammenfassung 相似文献
7.
This work defines a new class of hybrid systems called state-based switched (SBS) systems that have numerous important engineering applications. The characterizing feature of these systems is that the discrete-event dynamics are associated with the continuous-time state making a specific function be equal to zero. The choice of this function is application specific and for the closed-loop SBS systems defined in this paper it is related to the execution of a desired set of tasks from a pre-specified mission plan. For this broad class of SBS systems, the paper presents a unified analysis and controller synthesis methodology based on Lyapunov theory. Depending on the details of the mission plan, the closed-loop hybrid system will be divided into two subclasses: sequential and non-sequential. The controller design procedure for both subclasses consists of the same two steps: finding a control law and finding a stabilizing switching rule. For static state and output feedback of sequential hybrid systems, the paper proposes a new hybrid sequential sliding-mode controller. It is proven that the control mission can be accomplished for sequential hybrid systems under static state and output feedback using this new controller. A similar framework is investigated for the more complex class of nonsequential hybrid systems and a systematic procedure for designing the switching rule is presented for some specific instances of these systems. 相似文献
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9.
Ammonium dinitramide (ADN) prills were prepared by emulsion crystallization and characterized by optical microscopic, thermogravimetric
(TG) and differential scanning calorimetric (DSC) techniques. The isothermal and non-isothermal decomposition kinetics of
ADN prills were studied by TG. The differential isoconversional method of Friedman (FR) and integral isoconversional method
of Vyazovkin were used to investigate the dependence of activation energy (E
a) with conversion (α) and the results were compared with literature data. The dependence of activation energy was also derived
from isothermal data. A strong dependence of E
a with α is observed for the ADN prills. All the methods showed an initial increase in E
a up to α=∼0.2 and later decreases over the rest of conversion. The apparent E
a values of FR method are higher than that of Vyazovkin method up to α=∼0.45. The calculated mean E
a values by FR, Vyazovkin and standard isoconversional method for α between 0.05 and 0.95 were 211.0, 203.9 and 156.9 kJ mol−1, respectively. 相似文献
10.
Hao‐Wen Ko Mu‐Huan Chi Chun‐Wei Chang Chun‐Hsien Su Tzu‐Hui Wei Chia‐Chan Tsai Chi‐How Peng Jiun‐Tai Chen 《Macromolecular rapid communications》2015,36(5):439-446
Multi‐component polymer nanomaterials have attracted great attention because of their applications in areas such as biomedicine, tissue engineering, and organic solar cells. The precise control over the morphologies of multi‐component polymer nanomaterials, however, is still a great challenge. In this work, the fabrication of poly(methyl methacrylate)(PMMA)/polystyrene (PS) nanostructures that contain PMMA shells and encapsulated PS nanospheres is studied. The nanostructures are prepared using a triple solution wetting method with anodic aluminum oxide (AAO) templates. The nanopores of the templates are wetted sequentially by PS solutions in dimethylformamide (DMF), PMMA solutions in acetic acid, and water. The compositions and morphologies of the nanostructures are controlled by the interactions between the polymers, solvents, and AAO walls. This work not only presents a feasible method to prepare multi‐component polymer nanomaterials, but also leads to a better understanding of polymer‐solvent interactions in confined geometries.