全文获取类型
收费全文 | 43399篇 |
免费 | 6892篇 |
国内免费 | 4863篇 |
专业分类
化学 | 30138篇 |
晶体学 | 468篇 |
力学 | 2546篇 |
综合类 | 360篇 |
数学 | 5381篇 |
物理学 | 16261篇 |
出版年
2024年 | 156篇 |
2023年 | 913篇 |
2022年 | 1433篇 |
2021年 | 1513篇 |
2020年 | 1760篇 |
2019年 | 1644篇 |
2018年 | 1419篇 |
2017年 | 1371篇 |
2016年 | 2045篇 |
2015年 | 1960篇 |
2014年 | 2347篇 |
2013年 | 3077篇 |
2012年 | 3720篇 |
2011年 | 3788篇 |
2010年 | 2618篇 |
2009年 | 2453篇 |
2008年 | 2754篇 |
2007年 | 2470篇 |
2006年 | 2276篇 |
2005年 | 1941篇 |
2004年 | 1560篇 |
2003年 | 1327篇 |
2002年 | 1308篇 |
2001年 | 1067篇 |
2000年 | 942篇 |
1999年 | 1012篇 |
1998年 | 819篇 |
1997年 | 725篇 |
1996年 | 757篇 |
1995年 | 667篇 |
1994年 | 574篇 |
1993年 | 486篇 |
1992年 | 430篇 |
1991年 | 389篇 |
1990年 | 351篇 |
1989年 | 247篇 |
1988年 | 172篇 |
1987年 | 136篇 |
1986年 | 167篇 |
1985年 | 111篇 |
1984年 | 69篇 |
1983年 | 65篇 |
1982年 | 52篇 |
1981年 | 31篇 |
1980年 | 12篇 |
1979年 | 7篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1969年 | 1篇 |
1957年 | 8篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Synthesis of Small‐Sized,Porous, and Low‐Toxic Magnetite Nanoparticles by Thin POSS Silica Coating 下载免费PDF全文
Dr. Swee Kuan Yen D. Prathyusha Varma Wei Mei Guo Dr. Vincent H. B. Ho Dr. Vimalan Vijayaragavan Dr. Parasuraman Padmanabhan Prof. Kishore Bhakoo Prof. Subramanian Tamil Selvan 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(10):3914-3918
In this communication, we report the synthesis of small‐sized (<10 nm), water‐soluble, magnetic nanoparticles (MNPs) coated with polyhedral oligomeric silsesquioxanes (POSS), which contain either polyethylene glycol (PEG) or octa(tetramethylammonium) (OctaTMA) as functional groups. The POSS‐coated MNPs exhibit superparamagnetic behavior with saturation magnetic moments (51–53 emu g?1) comparable to silica‐coated MNPs. They also provide good colloidal stability at different pH and salt concentrations, and low cytotoxicity to MCF‐7 human breast epithelial cells. The relaxivity data and magnetic resonance (MR) phantom images demonstrate the potential application of these MNPs in bioimaging. 相似文献
2.
3.
4.
5.
Simultaneous quantitative determination of 20 active components in the traditional Chinese medicine formula Zhi‐Zi‐Da‐Huang decoction by liquid chromatography coupled with mass spectrometry: application to study the chemical composition variations in different combinations 下载免费PDF全文
Zheng Tang Ran Yin Kaishun Bi Heyun Zhu Fei Han Kelin Chen Fenrong Wang 《Biomedical chromatography : BMC》2015,29(9):1406-1414
6.
Studies on metabolites and metabolic pathways of bulleyaconitine A in rat liver microsomes using LC‐MSn combined with specific inhibitors 下载免费PDF全文
Hongbin Zhu Fengrui Song Zhiqiang Liu Shuying Liu 《Biomedical chromatography : BMC》2015,29(7):1027-1034
Bulleyaconitine A (BLA) from Aconitum bulleyanum plants is usually used as anti‐inflammatory drug in some Asian countries. It has a variety of bioactivities, and at the same time some toxicities. Since the bioactivities and toxicities of BLA are closely related to its metabolism, the metabolites and the metabolic pathways of BLA in rat liver microsomes were investigated by HPLC–MSn. In this research, the 12 metabolites of BLA were identified according to the results of HPLC‐MSn data and the relevant literature. The results showed that there are multiple metabolites of BLA in rat liver microsomes, including demethylation, deacetylation, dehydrogenation deacetylation and hydroxylation. The major metabolic pathways of BLA in rat liver microsomes were clarified by HPLC‐MS combined with specific inhibitors of CYP450 isoforms. As a result, CYP3A and 2C were found to be the principal CYP isoforms contributing to the metabolism of BLA. Moreover, CYP2D6 and 2E1 are also more important CYP isoforms for the metabolism of BLA. While CYP1A2 only affected the formation rate of M11, its effect on the metabolism of BLA is very small. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
7.
8.
Ionics - This study aims to explore the potential merits of palladium oxide sensing electrode. PdO is applied on a solid-state potentiometric sensor on an yttria-stabilized zirconia (YSZ)... 相似文献
9.
Jigneshkumar P. Patel Zou Guo Xiang Shaw Ling Hsu Andrew B. Schoch Sena Ada Carleen Dean Matsumoto 《Journal of Polymer Science.Polymer Physics》2015,53(21):1519-1526
A uniform dispersion of reactants is necessary to achieve a complete reaction involving multicomponents. In this study, we have examined the role of plasticizer in the reaction of two seemingly unlikely reactants: a highly crystalline hexamethylenetetramine (HMTA) and a strongly hydrogen bonded phenol formaldehyde resin. By combining information from NMR, infrared spectroscopy and differential scanning calorimetry, we were able to determine the role of specific intermolecular interactions necessary for the plasticizer to dissolve the highly crystalline HMTA and to plasticize the phenol formaldehyde resin in this crosslinking reaction. The presence of the plasticizer increased the segmental mobility, disrupted the hydrogen bonded matrix, and freed the hydroxyl units, which further increased the solubility of the HMTA. Both the endothermic and exothermic transitions are accounted for in the calorimetric data obtained. For the first time, it is possible to obtain the effective molar ratio of each component needed to complete the crosslinking reaction efficiently. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2015 , 53, 1519–1526 相似文献
10.
Metabolic profiles of dioscin in rats revealed by ultra‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry 下载免费PDF全文
He Zhu Jin‐Di Xu Qian Mao Hong Shen Ming Kong Jian‐Ping Chen Song‐Lin Li 《Biomedical chromatography : BMC》2015,29(9):1415-1421
Dioscin (DIS), one of the most abundant bioactive steroidal saponins in Dioscorea sp., is used as a complementary medicine to treat coronary disease and angina pectoris in China. Although the pharmacological activities and pharmacokinetics of DIS have been well demonstrated, information regarding the final metabolic fates is very limited. This study investigated the in vivo metabolic profiles of DIS after oral administration by ultra‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry method. The structures of the metabolites were identified and tentatively characterized by means of comparing the molecular mass, retention time and fragmentation pattern of the analytes with those of the parent compound. A total of eight metabolites, including seven phase I and one phase II metabolites, were detected and tentatively identified for the first time. Oxidation, deglycosylation and glucuronidation were found to be the major metabolic processes of the compound in rats. In addition, a possible metabolic pathway on the biotransformation of DIS in vivo was proposed. This study provides valuable and new information on the metabolism of DIS, which will be helpful for further understanding its mechanism of action. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献