Relating neural dynamics to neural coding

We demonstrate that two key theoretical objects used widely in computational neuroscience, the phase-resetting curve (PRC) from dynamics and the spike triggered average (STA) from statistical analysis, are closely related when neurons fire in a nearly regular manner and the stimulus is sufficiently small. We prove that the STA due to injected noisy current is proportional to the derivative of the PRC. We compare these analytic results with numerical calculations for the Hodgkin-Huxley neuron and we apply the method to neurons in the olfactory bulb of mice. This observation allows us to relate the stimulus-response properties of a neuron to its dynamics, bridging the gap between dynamical and information theoretic approaches to understanding brain computations and facilitating the interpretation of changes in channels and other cellular properties as influencing the representation of stimuli.     

The formation of,and the γ-radiation from,the p-shell hypernuclei

The physical factors relevant for the production of various low-lying Λ-hypernuclear states ${}_{\mathrm{\Lambda }}{}^{\mathrm{A}}\text{Z}{}^1$ through the K^? → π^? and K^? → π⁰ reactions, in flight or from rest, on the corresponding target nuclei ^AZ and ^A(Z + 1) are discussed, on the basis of the shell model for these nuclei and hypernuclei, together with the characteristics of the dominant γ-transitions resulting from the excited states thus produced. Detailed consideration is given for a number of hypernuclei of specific interest, including the cases of _Λ⁷He, _ΛLi for A = 7, 9 and 10, _ΛBe for A = 9 and 10, _ΛB for A = 10, 11, and 12, _ΛC for A = 12, 13, 14, and 15, _ΛN for A = 14 and 15, and _Λ¹⁶O. The importance of (γ, π^?) correlation studies for the determination of hypernuclear spin values is stressed, with the discussion of several examples.     

Two-nucleon production of hyperons and the search for strange dibaryons

The double charge exchange reaction³He(K^?,π ⁺)Xn was studied at 870 MeV/c. In the X missing mass range below the sigma-nucleon production threshold (2130 MeV/c²), events were detected which can be attributed to the two-nucleon process pp(K^?,π ⁺)λn. This reaction and mass range also offers good prospects for finding theI=1/2,l=1 (¹ P₁) spin-singlet dibaryon D_s suggested as the lowest massS=?1 dibaryon in the MIT Bag Model. Although the existence of the D_s is not ruled out by the present data, there is no need to invoke such an object to account for the observed events below σ production threshold. We show that the cross section level for these events is compatible with a dominant two-nucleon mechanism K^?p→π ⁰λ,π ⁰p →π ⁺n. We also offer an interpretation of the recent (K^?,K⁺) data on nuclear targets from Iijimaet al., which display a broad peak centered around a K⁺ momentum of 600 MeV/c. We find that the two-nucleon mechanism K^?N →πY,πN→K⁺Y produces cross sections which are at least an order of magnitude smaller than those observed, and we suggest that the one nucleon process K^?p →Φλ, followed by the decayΦ → K⁺K^?, accounts for the data.     

Excitation and decay of the isovector giant monopole resonances via the 208Pb(3He,t p) reaction at 410 MeV

The excitation and subsequent proton decay of the isovector spin-flip giant monopole resonance (IVSGMR) is studied via the 208Pb(3He,t) reaction at 410 MeV. In the inclusive spectrum (60+/-5)% of the non-energy-weighted sum-rule strength for this 2 variant Planck's over 2h omega resonance was found in the region 29相似文献   

Synthesis and characterization of chemically anchored adenosine with PHEMA grafted gold nanoparticles

The synthesis of chemically anchored adenosine with biocompatible poly(2-hydroxylethyl methacrylate) grafted gold nanoparticles (Ado-i-PHEMA-g-AuNPs) was realized by employing a simple strategy. Disulfide-containing poly(2-hydroxylethyl methacrylate) (DT-PHEMA) was initially synthesized by atom transfer radical polymerization (ATRP). The formation of DT-PHEMA was confirmed by ¹H-NMR and FT-IR. The molecular weight and molecular weight distribution were found to be 9.6 kg/mol and 1.40 from GPC analysis. DT-PHEMA was subsequently used for the synthesis of PHEMA-g-AuNPs by a grafting to protocol. The grafting of DT-PHEMA on the surface of AuNPs was confirmed by FT-IR, TGA, XPS, and EDX analyses. The particle size of the PHEMA-g-AuNPs was found to be ca. 5.0 nm from HR-TEM analysis. Boronic acid was used for functionalization of PHEMA-g-AuNPs, which was then subjected for covalent immobilization with adenosine via strong interaction between free hydroxyl groups of adenosine and boronic acid. Characterization and properties of the Ado-i-PHEMA-g-AuNPs were investigated by taking advantage from FT-IR, XPS, EDX, and UV-visible spectroscopy. The Ado-i-PHEMA-g-AuNPs nanocomposite exhibits a surface plasmon resonance peak at 586 nm which is red shifted from AuNPs (521 nm), indicating significant changes of surface property upon PHEMA-adenosine immobilization onto the surface of AuNPs.     

Quasi-Newton ABS methods for solving nonlinear algebraic systems of equations

This paper is concerned with the solution of nonlinear algebraic systems of equations. For this problem, we suggest new methods, which are combinations of the nonlinear ABS methods and quasi-Newton methods. Extensive numerical experiments compare particular algorithms and show the efficiency of the proposed methods.The authors are grateful to Professors C. G. Broyden and E. Spedicato for many helpful discussions.     

Remote characterization of defects in plates with viscoelastic coatings using guided waves

The remote inspection for defects in large metallic elements such as pipes, tubes and plates is a field where guided waves are being applied with success. There are a number of situations where a surface coating is added for corrosion protection or insulation purposes. Since the coating materials are usually viscoelastic, the guided wave inspection range may be severely reduced unless a proper mode and an adequate frequency range is selected. Previous authors found the existence of low-attenuated modes at certain frequency ranges, which were used to detect and locate defects at reasonably large distances. This paper studies the potential of guided waves for not only locating but also sizing defects in plates with viscoelastic coatings. A hybrid finite element-boundary element method which explicitly includes the attenuating characteristics of the coating is used to determine Lamb and SH mode conversion factors at corrosion defects under the coating. Through parametric studies and analysis of the numerical results, some trends and features are highlighted that could be used for sizing purposes.