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Fazila ZulfiqarSamir A. Ross Desmond Slade Safwat A. Ahmed Mohamed M. RadwanZulfiqar Ali Ikhlas A. Khan Mahmoud A. ElSohly 《Tetrahedron letters》2012,53(28):3560-3562
Cannabisol (1), a unique dimer of Δ9-tetrahydrocannabinol (Δ9-THC) with a methylene bridge, was isolated from Cannabis sativa. This is the first example of a C-bridged dimeric cannabinoid. The structure of 1 was unambiguously deduced by HRESIMS, GCMS, and NMR spectroscopy. A plausible biogenesis of 1 is described. 相似文献
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Fazila Seker Arthur B. Ellis 《Journal of polymer science. Part A, Polymer chemistry》1998,36(12):2095-2102
The thermoshrinking properties have been studied for the series of N-alkyl-acrylamide hydrogels (alkyl = methyl, ethyl, isopropyl, and n-propyl), which were prepared by free-radical copolymerization of the alkylacrylamide, sodium acrylate, and N,N′-methylenebis(acrylamide) (BIS) in aqueous solution. The reaction mixtures were prepared using the same nominal compositions in an effort to study the effect of the chemical structure of the alkyl substituent on the gel swelling behavior as a function of temperature. The alkyl group was found to have a pronounced effect on the features of gel swelling. Generally, larger alkyl chains produced dramatic decreases in gel transition temperature. In addition, a change in the nature of the swelling behavior from continuous to discontinuous was noted upon changing the alkyl group from ethyl to the two propyl derivatives. Discontinuous transitions were accompanied by hysteresis. The transition temperatures of the isomeric propyl derivatives were found to differ by 12°C, with n-propyl exhibiting the lower value. Additionally, a quantitative correlation was found between the gel transition temperatures and the water/octanol partition coefficients for appropriately chosen small molecule model compounds. The transition temperatures of other gels in the series, including the cyclopropyl derivative and the n-propyl/isopropyl copolymer gels (NIPA/NNPA), also fit this correlation. © 1998 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 36: 2095–2102, 1998 相似文献
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Sanne J. M. Verhoork Dr. Claire E. Jennings Neshat Rozatian Dr. Judith Reeks Jieman Meng Emily K. Corlett Fazila Bunglawala Prof. Martin E. M. Noble Dr. Andrew G. Leach Dr. Christopher R. Coxon 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(1):177-182
A growing number of approaches to “staple” α-helical peptides into a bioactive conformation using cysteine cross-linking are emerging. Here, the replacement of l -cysteine with “cysteine analogues” in combinations of different stereochemistry, side chain length and beta-carbon substitution, is explored to examine the influence that the thiol-containing residue(s) has on target protein binding affinity in a well-explored model system, p53–MDM2/MDMX, which is constituted by the interaction of the tumour suppressor protein p53 and proteins MDM2 and MDMX, which regulate p53 activity. In some cases, replacement of one or more l -cysteine residues afforded significant changes in the measured binding affinity and target selectivity of the peptide. Computationally constructed homology models indicate that some modifications, such as incorporating two d -cysteine residues, favourably alter the positions of key functional amino acid side chains, which is likely to cause changes in binding affinity, in agreement with measured surface plasmon resonance data. 相似文献
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Siddiqui Hina Baheej M. A. A. Ullah Saeed Rizvi Fazila Iqbal Shazia Haniffa Haroon M. Wahab Atia-tul Choudhary M. Iqbal 《Molecular diversity》2022,26(4):2049-2067
Molecular Diversity - The current study was aimed to discover potent inhibitors of α-glucosidase enzyme. A 25 membered library of new 1,2,3-triazole derivatives of hydrochlorothiazide (1)... 相似文献
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In our natural product screening program, we screened natural products for their repellency and toxicity against insect vectors. Methanolic extract of aerial parts of Stenaria nigricans (Lam.), with no published chemistry, was tested for repellency against mosquitoes and imported hybrid fire ants. Methanolic extracts showed biting deterrence similar to DEET (N,N-diethyl-3-methylbenzamide) against Aedes aegypti L. Based on this activity, the crude extract was fractionated into chloroform, ethyl acetate, and methanol subfractions. The active methanolic subfraction was further fractionated into 13 subfractions. These fractions were tested for their biting deterrence against Ae. Aegypti. Active subfractions were further characterized to identify the compounds responsible for this activity. Four undescribed iridoid glucosides (1–4) and three previously reported compounds (5–7) were isolated from active subfractions and tested for their biting deterrent activity. Based on BDI values, compounds 2, 3, 6, and 7, with biting deterrence similar to DEET, showed the potential to be used as repellents against mosquitoes. In an in vitro digging bioassay, none of these compounds showed any repellency against hybrid imported fire ants at a dose of 125 µg/g. This is the first report of biting deterrence and repellency of S. nigricans extract and its pure compounds, iridoid glucosides against mosquitoes and imported fire ants. Further studies will be conducted to explore the repellent potential of these compounds in different formulations under field conditions. 相似文献
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