Here we reported the radiolabeling and evaluation of a novel 131I-radiolabeled quercetin for the treatment of dedifferentiated thyroid cancers. The human thyroid cancer cell lines (FTC-133, TT and DRO) experienced much higher uptake of 131I-quercetin as compared to the free 131I. And the proliferation inhibition rate of 131I-quercetin on in vitro DRO cell line was 86.87 ± 7.15%. Biodistribution and SPECT analysis demonstrated that the injected radioactivity mainly accumulated in tumors. The tumor volume in the treatment group was dramatically inhibited in comparison with the control group. 相似文献
A practical synthetic strategy to a chiral azabicycclooctanyl derivative (1), a potent DPP-4 inhibitor, starting from a commercially available nortropine is described. The stereogenic center of 1 was established employing a modified protocol of Ellman's diastereoselective addition of a benzylic nucleophile to tert-butanesulfinimine. Other key steps include Corey-Chaykovsky reaction, Meinwald rearrangement, and CDMT-promoted amide bond formation involving a sterically hindered amine 2. 相似文献
Uniform one‐dimensional V2O5@polyaniline core/shell nanobelts have been fabricated by a simple in‐situ polymerization method in the absence of any surfactant and additional initiator. The influences of pH and additional initiator on the morphology of the resulting products are investigated. The pH value is important for the formation of V2O5@polyaniline core/shell nanobelts, which preserve the original morphology of V2O5 nanobelts. With a decrease in the pH value to 0 the original morphology of the V2O5 nanobelts is destroyed. When ammonium peroxydisulfate is used, some separated polyaniline nanofibers are formed. The formation of the V2O5@polyaniline core/shell nanobelts can be related to the in‐situ polymerization of aniline monomer by etching V2O5 nanobelts. The electrochemical lithium intercalation/deintercalation of V2O5@polyaniline core/shell nanobelts is investigated by cyclic voltammograms.
The impact of a mixture of low-molecular-weight organic acids (LMWOAs) composed of CA/MA/OA/LA with a molar ratio of 2.5:2.31:1.15:0.044 on uranium (U) accumulation and distribution in mustard (Brassica juncea var. tumida) was studied in this paper in order to understand the mechanism of rhizosphere-exudation assisted phytoremediation by hydroponic and pot culture experiments. The impact of the mixture of LWMOAs (Mix) on U accumulation showed that in hydroponic conditions Mix could enhance U translocation from root-to-shoot in mustard, but inhibit U uptake in root. In pot experiments, Mix enhanced both root and shoot U accumulation in mustard. The time-dependent kinetics of U uptake in mustard on Mix treatment showed that U content in plant shoots and roots increased with time increasing, and the steady state conditions were obtained at the 8th and 5th day with the U content of 1,528 and 2,300 mg/kg, respectively. Transmission electron microscope and energy dispersive X-ray spectrometry analysis for mustard roots showed that U was mainly observed on cell membrane of mustard roots on Mix treatment. This study would provide new insights for the mixture of LWMOAs-assisted phytoremediation of U-contaminated soil. 相似文献
An improved and facile preparation of tyramine [2‐(p‐hydroxyphenyl)ethylamine] was described, which starts from phenol and acrylonitrile to form β‐(p‐hydroxyphenyl) propionic acid via Friedel‐Craft's alkylation and nitrile hydrolysis. After hydrazinolysis and a subsequent Curtius rearrangement, tyramine was obtained in 30.2% total yield. 相似文献