排序方式: 共有17条查询结果,搜索用时 15 毫秒
1.
Madalina Tudose Florin D. Badea Gabriela Ionita Maria Maganu Miron T. Caproiu Petre Ionita Titus Constantinescu Alexandru T. Balaban 《Structural chemistry》2010,21(6):1227-1234
Starting from 4-chloro-3,5-dinitrobenzoic acid 1, compounds 2–10 (N-alkoxy-3,5-dinitro-4-aminobenzoic acid esters where alkoxy stands for methoxy, carboxymethoxy, triphenylmethoxy, or corresponding
amides) have been obtained, from which compounds 3–5 and 7–10 are new, and for the known compounds 2 and 6 the synthetic procedure has been improved. The new derivatives have been characterized by appropriate means (IR, UV–Vis,
1H- and 13C-NMR, fluorescence) and their properties were studied. Thus, depending on their structure, the compounds have acid properties,
fluorescence and complexing properties with alkaline cations. 相似文献
2.
Madalina Tudose Florin D. Badea Miron T. Caproiu Adrian Beteringhe Maria Maganu Petre Ionita Titus Constantinescu Alexandru T. Balaban 《Central European Journal of Chemistry》2010,8(4):789-796
Starting from N-hydroxyphthalimide 1 and the reactive fluoro- or chloro-nitroaryl derivatives 2, 3 and 4a-e (2-chloro-3,5-dinitropyridine; 3, NBD-chloride; 4a, 1-fluoro-2,4-dinitrobenzene; 4b, picryl chloride; 4c, 4-chloro-3,5-dinitrobenzotrifluoride; 4d, 2-chloro-3,5- dinitrobenzotrifluoride; 4e, 4-chloro-3,5-dinitrobenzoic acid) the corresponding N-(2-nitroaryloxy)-phthalimide derivatives 5a-e, or 6 and 7 were obtained and characterized by IR, UV-Vis 1H-NMR and 13C-NMR spectroscopy. The TLC behavior and the hydrophobicity of these derivatives have been experimentally evaluated by RM0 parameters (using RP-TLC). The experimental RM0 parameters were compared with the calculated partition coefficient, log P. A QSPR study was also performed to establish possible
correlations between the structure and physical properties (λmax and RM0) of compounds 5a-e, 6, and 7.
相似文献
3.
4.
Beteringhe Adrian Baciu Ion Caproiu Miron T. Constantinescu Titus Balaban Alexandru T. 《平面色谱法杂志一现代薄层色谱法》2003,16(4):268-270
JPC – Journal of Planar Chromatography – Modern TLC - The Z (1b and 2b, respectively) and E diastereomers (1c and 2c, respectively) of the O-methyloximes of testosterone (1a) and... 相似文献
5.
Dumitrascu F Caira MR Draghici C Caproiu MT Badoiu A 《Molecules (Basel, Switzerland)》2005,10(2):321-326
The 3+2 cycloaddition reaction of 1-(4-phenylphenacyl)-1,10-phenanthrolinium ylide 4 with activated alkynes gave pyrrolo[1,2- 4a][1,10]phenanthrolines 6a-d. The "one pot" synthesis of 6a,b,d from 4, activated alkenes, Et(3)N and tetrakis-pyridine cobalt (II) dichromate (TPCD) is described. The helical chirality of pyrrolophenanthrolines 6b-d was put in evidence by NMR spectroscopy. 相似文献
6.
Synthesis of 2,4-dimethyl-6-oxo-2,4-heptadienoic acid derivatives from 2,4,6-trimethylpyrylium salts
Reaction 2,4,6-trimethylpyrylium salts with sodium cyanide in boiling water yielded the bicyclic lactone 1,3,5-trimethyl-6,8-dioxabicyclo[3.2.1]oct-2-en-7-one (6) along with a series of stereoisomers of 2,4-dimethyl-6-oxo-2,4-heptadienonitrile (5), which were the sole products when the reaction was carried out at room temperature. Compound 6, along with 3,5-dimethylphenol (7), was also obtained by refluxing 5 briefly in aqueous sodium hydroxide. However, when 5 was refluxed for a prolonged period in aqueous sodium acetate, 3,5-dimethyl-5-(2-oxopropyl)-furan-2-one (8), along with some 7, was generated instead. Compound 8 could also be produced from 6 on prolonged refluxing with aqueous sodium acetate, indicating that 6 was the kinetically-controlled and 8 the thermodynamically-controlled product. 相似文献
7.
Marioara Bem Miron T. Caproiu Dan Stoicescu Titus Constantinescu Alexandru T. Balaban 《Central European Journal of Chemistry》2003,1(3):260-276
4-Chloro-7-nitrobenzofurazan reacts by nucleophilic substitution with phenoxide anions derived from estriol (2c), ethynylestradiol (2d), phenol (3e), guaiacol (3f), 2,6-dimethoxyphenol (3g), eugenol (3h), isoeugenol (3i), the cytostatic Etoposide (4), and Reichardt’s betaine (5) in the presence of crown ethers affording the corresponding 4-aryloxy-7-nitrobenzofurazan derivatives 6c, 6d, 7e-7i, 8, and 9. The structure of these compounds was confirmed by NMR spectra. Hydrophobicity/hydrophilicity parameters were investigated
by reverse phase thin-layer chromatography. 相似文献
8.
F.?Dumitra?cu M.?R.?CairaEmail author C.?Draghici M.?T.?Caproiu L.?Barbu A.?Badoiu 《Journal of chemical crystallography》2005,35(5):361-365
The objective of the study was to confirm by X-ray analysis the phenomenon of helical chirality inferred from solution 1H-NMR data for a series of derivatives based on the novel pyrrolo[1,2-a][1,10]phenanthroline system. The syntheses of the title compounds and their 1H-NMR data are presented. Crystals of the representative compound ethyl, 1-(4-phenylbenzoyl)-pyrrolo[1,2-a][1,10]phenanthroline-3-carboxylate, with molecular formula C31H22N2O3, were found to crystallize in the triclinic system, space group P 1 with a = 7.8541(1), b = 11.2605(2), c = 13.4093(3) Å, = 92.244(1), = 90.292(1), = 106.475(1) and Z = 2. The X-ray analysis revealed the predicted helicity of the phenanthroline system as well as its origin, namely the proximity of the pyridine N atom and the carbonyl C atom of the phenylbenzoyl residue, with non-bonded distance N s C of only 2.465(2) Å. A secondary, but significant distortion, involving displacement of the carbonyl C atom by more than 0.5 Å from the pyrrole ring, was evident. The crystal structure is maintained by C–H s O hydrogen bonds and – interactions. 相似文献
9.
Anca Paun Irina Zarafu Miron T. Caproiu Constantin Draghici Maria Maganu Ani I. Cotar Mariana C. Chifiriuc Petre Ionita 《Comptes Rendus Chimie》2013,16(7):665-671
Starting from benzocaine, a well-known anaesthetic, ten derivatives were synthesized and characterized by UV–vis, IR, NMR, and elemental analysis. Most of the compounds contain residues with recognized biological activity, like nicotinic acid (vitamin B3 or PP), biotin (vitamin B7 or H), lipoic acid (thioctic acid), adamantine, as well as other residues of crown-ether type, benzofurazane, naphtylurea, di- and tri-nitrobenzene, and a nitroxide radical. The biological evaluation of the obtained compounds included hydrophobicity (lipophobicity) assay, total antioxidant and microbiological activity tests. 相似文献
10.
Carmen Limban Alexandru V. Missir Ileana C. Chirita George M. Nitulescu Miron T. Caproiu Mariana C. Chifiriuc Anca M. Israil 《Chemical Papers》2011,65(1):60-69
New acylthiourea derivatives, 2-((4-ethylphenoxy)methyl)-N-(phenylcarbamothioyl)benzamides, were tested by qualitative and quantitative methods on various bacterial and fungal strains
and proved to be active at low concentrations against Gram-positive and Gram-negative bacteria as well as fungi. These compounds
were prepared by the reaction of 2-((4-ethylphenoxy)methyl)benzoyl isothiocyanate with various primary aromatic amines, and
were characterised by melting point and solubility. The structures were identified by elemental analysis, 1H and 13C NMR, and IR spectral data. The level of antimicrobial activity of the new 2-((4-ethylphenoxy)methyl)benzoylthiourea derivatives
was dependent on the type, number and position of the substituent on the phenyl group attached to thiourea nitrogen. The iodine
and nitro substituents favoured the antimicrobial activity against the Gram-negative bacterial strains, while the highest
inhibitory effect against Gram-positive and fungal strains was exhibited by compounds with electron-donating substituents
such as the methyl and ethyl groups. 相似文献