排序方式: 共有4条查询结果,搜索用时 4 毫秒
1
1.
Hania Hebbache Zakia Hank Sultana Boutamine M'hamed Meklati Christian Bruneau Jean-Luc Renaud 《Comptes Rendus Chimie》2008,11(6-7):612-619
The direct condensation of amines with β-ketoesters to produce functional enamine derivatives has been investigated with iron Lewis acid catalysts. FeCl3·6H2O shows good catalytic activity and makes possible the chemo- and stereoselective formations of (Z)-enamine derivatives from aliphatic and aromatic primary amines under mild conditions. 相似文献
2.
Pascal Pigeon Ouardia Zekri Elizabeth A. Hillard Marie-Aude Plamont Eric Labbé Sultana Boutamine Gérard Jaouen 《Journal of organometallic chemistry》2009,694(6):895-901
We have previously shown that conjugated ferrocenyl p-phenols show strong cytotoxic effects against both the hormone-dependent MCF-7 and hormone-independent MDA-MB-231 breast cancer cell lines, possibly via oxidative quinone methide formation. We now present a series of analogous amine and acetamide compounds: 2-ferrocenyl-1-(4-aminophenyl)-1-phenyl-but-1-ene (Z+E-2), 2-ferrocenyl-1-(4-N-acetylaminophenyl)-1-phenyl-but-1-ene (Z-3), and their corresponding organic molecules 1-(4-aminophenyl)-1,2-bis-phenyl-but-1-ene (Z+E-4) and 1-(4-N-acetamidophenyl)-1,2-bis-phenyl-but-1-ene (Z+E-5). All of the compounds have adequate relative binding affinity values for the estrogen receptor; between 2.8% and 5.7% for ERα, and between 0.18% and 15.5% for ERβ, as well as exothermic ligand binding in in silico ER docking experiments. Compounds 2 and 3 show dual estrogenic/cytotoxic activity on the MCF-7 cell line; they are proliferative at low concentrations (0.1 μM) and antiproliferative at high concentrations (10 μM). On the MDA-MB-231 cell line, the ferrocenyl complexes 2 and 3 are antiproliferative with IC50 values of 0.8 μM for 2 and 0.65 μM for 3, while the purely organic molecules 4 and 5 show no effect. Electrochemical experiments suggest that both 2 and 3 can be transformed to oxidized quinoid-type species, analogous to what had previously been observed for the ferrocene phenols. 相似文献
3.
S. Boutamine Z. Hank M. Meklati O. Benali-Baitich 《Journal of Radioanalytical and Nuclear Chemistry》1994,185(2):347-353
The effect of pH on the percent extraction of vanadium(V), iron(II), cobalt(II), nickel(II), copper(II), molybdenum(VI), tungsten(VI) and uranium(VI) by -benzoinoxime in different solvents has been studied. The maximum recovery is not appreciably affected by the nature of the solvent, but occurs at different pH values for different metals. The pH corresponding to maximum extraction increases with increasing hydrolysis pK of the species in aqueous solution, and decreases with increasing stability constant of the complexes formed. Alpha-benzoinoxime allows the separation of these metal ions into three groups: V(V), Mo(VI) and W(VI) are extracted at pH=2, U(VI) at pH=5, Fe(II), Cu(II), Co(II) and Ni(II) at around pH=10. 相似文献
4.
1