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Conjugates with an Antimicrobial Effect Based on New Derivatives of Mercaptobenzoxazole Esterified onto Poly(maleic anhydride‐alt‐vinyl acetate)
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Radita Aparaschivei Valeriu Şunel Marcel Popa Jacques Desbrieres 《Journal of heterocyclic chemistry》2014,51(4):1124-1132
New compounds with biological activity based on hydroxy‐amino derivatives of benzoxazolyl‐2‐mercaptoformic acid, benzoxazolyl‐2‐mercaptoacetic acid, and chloracetyl‐2‐mercaptobenzoxazole have been synthesized. The chemical bonding of these compounds to poly(maleic anhydride‐alt‐vinyl acetate), through esterification, leads in obtaining conjugates of polymer biologically active compound type, tests indicating a sustained release of the active chemical, with time (between 5 and 6 h). Reaction products were characterized through elemental and spectral analysis (FTIR and 1H NMR). Toxicology and antimicrobial activity tests recommend compounds with small molecule, as well as their conjugates as therapeutical candidates (antimicrobial inhibitors) for pharmacological application. 相似文献
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Todea Anamaria Aparaschivei Diana Bîtcan Ioan Ledeți Ionuț Valentin Bandur Geza Péter Francisc Nagy Lajos Kéki Sándor Biró Emese 《Journal of Thermal Analysis and Calorimetry》2020,141(3):1017-1026
Journal of Thermal Analysis and Calorimetry - The thermal behavior of co-oligomers of ε-caprolactone (ECL) with gluconolactone, compared to the ε-caprolactone oligomer, has been assessed... 相似文献
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Rǎdiţa Aparaschivei Valeriu Şunel Mihaela Holban Marcel Popa Jacques Desbrieres 《Central European Journal of Chemistry》2013,11(11):1808-1815
New potentially biologically active compounds derived from 2-mercapto-benzoxazole were synthesized and coupled on polymeric support of poly (maleic anhydride-alt-vinyl acetate) for the preparation of polymer-drug conjugates with controlled drug release. All compounds were characterized by elemental and spectroscopy (FT-IR, 1H-NMR) analysis. The toxicological tests recommend the products for further laboratory screening. 相似文献
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