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药物的多晶型对药品质量和临床药效有较大的影响,药物多晶型的研究方法有x—射线单晶结构分析,x—射线粉末法,差热分析,红外光谱分析等。影响晶型转变的因素很多,如研磨,结晶溶剂不同或改变结晶条件,所得产品晶型即有变化。本实验通过盐酸林可霉素针、片剂红外光谱测定,x—射线衍射分析,差示扫描量热法,晶型转化实验等手段,证明盐酸林可霉素为一多晶型药物,晶型之间存在互变,晶型的不同是由于精制浓度及速度不同所致,其中晶B、晶C为稳定型晶态,晶A为亚稳态晶型。 相似文献
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Within the framework of the dynamical classical over-barrier model,the soft collisions between slow highly charged ions(SHCIs) Ar 17+ and the large copper clusters under large impact parameters have been studied in this paper.We present the dominant mechanism of the electron transfer between SHCIs and a large metal cluster by computational simulation.The evolution of the occupation of projectile ions,KL x satellite lines,X-ray yields,Auger electron spectrum and scattering angles are provided. 相似文献
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