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2,6-二氧杂双环[3.2.1]辛烷类衍生物的串联合成 总被引:1,自引:0,他引:1
以2-甲基-4-戊烯-1,2-二醇和芳香醛为原料, 三氯化铟为催化剂, 得到了一系列1,3-二取代2,6-二氧杂双环[3.2.1]辛烷类衍生物. 整个反应采用一锅法, 反应条件简单且产率高. 所有的化合物均用1H NMR, 13C NMR和质谱法进行了表征, 并用NOESY确立了分子的相对构型. 相似文献
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以2-乙氧基乙胺和3-氯-1-丙醇等为起始原料, 经7步反应, 制备了N,N-二[二(3-甲氧基丙基)膦基乙基]-2-乙氧基乙胺(PNP5)盐酸盐, 其中关键步骤是后两步. PNP5盐酸盐的结构和组成通过IR, 1H NMR, 13C NMR, 31P NMR, MS和元素分析等方法确认. 相似文献
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以吡唑膦亚胺、芳基异氰酸酯和芳基甲酰肼为原料,通过串联氮杂Wittig反应关环合成了12种新型的5-芳甲酰胺基-6-芳胺基-吡唑并[3,4-d]嘧啶-4-酮衍生物(3a~3l),其结构经1H NMR, 13C NMR, IR和HR-MS(ESI)表征。对单双子叶除草活性的初步测试结果发现:部分化合物具有优异的除草活性,特别是浓度为100 mg·L-1时,5-(4-氟苯甲酰胺基)-6-(4-氯苯胺基)-3-甲硫基-1-苯基-1H-吡唑[3,4-d]-嘧啶-4(5H)-酮3i和5-(4-吡啶苯甲酰胺基)-6-(4-氯苯胺基)-3-甲硫基-1-苯基-1H-吡唑[3,4-d]-嘧啶-4 (5H)-酮3k对油菜和稗草的茎和根的抑制率高达100%。 相似文献
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1974年Sweeton等人首先报道了这一反应[1]。1981年樊美公等报道了1,3-二甲基-6-氮杂胸腺嘧啶(A)与庚烯-1的反应[2],1986年又相继报道了含有极性基团的烯类与A的反应。本文通过这类反应合成了新化合物:1,2,4-三氮杂-2,4,6,7-四甲基-3,5-二氧-8-正丁基双环[4,2,0]辛烷(Ⅰ)和1,2,4-三氮杂-2,4,6-三甲基-3,5-二氧叁环[6,4,0,07,12]十二烷甲基衍生物(Ⅱ)。 相似文献
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以六氟异丙醇作溶剂,α-溴代酰胺在三乙胺作用下脱去一分子溴化氢,原位生成氮杂氧杂烯丙基离子中间体,再与硝酮发生[3+3]环加成反应,高收率合成了一系列1,2,4-噁二嗪-5-酮类化合物,其结构经1H NMR, 13C NMR, HR-MS(ESI)和X-射线单晶衍射确证。 相似文献
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单炔基桥联双杯[4]芳烃的合成与对溶剂分子的包合性能 总被引:1,自引:1,他引:0
对叔丁基杯[4]芳烃直接与1,4-二氯-2-丁炔反应,一步制备了单炔基单桥联双杯[4]芳烃和单炔基双桥联双杯[4]芳烃,并证实单桥联双杯[4]芳烃是双桥联双杯[4]芳烃的中间产物.经1HNMR,13CNMR和ESI-MS分析证实了产物的结构.ESI-MS结果表明两种产物对DMF和H2O有不同的包合能力. 相似文献
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Fawi M. Abd El Latif Eman A. Ei Rady Mohamed A. Khalil 《Phosphorus, sulfur, and silicon and the related elements》2013,188(10):2497-2505
2-Cyano-2-nitrosomethylbenzthiazole reacts with some active methylene and nucleophile derivatives to yield new fused and isolated polyfunctional pyrazine, -[1,2,4]triazine, -[1,4,5]benzoxadiazepin, -[1,4,5]benzothiadiazepine, [1,4,5]benzotriazepine, -triazole and -triazolo[3,2-c]triazine derivatives in one-pot reaction. The structures were based on IR, MS, and 1 H NMR spectra and elemental data. 相似文献
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硫杂杯[4]二醛基衍生物(1)在水合肼中肼解,合成了新化合物硫杂杯[4]二醛腙基衍生物(2);1和2在弱酸的催化下反应合成了新的具有对称结构的苄连氮双硫杂杯[4]芳烃(3);2和3的结构经1H NMR,IR,ESI-MS和元素分析表征. 相似文献
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The series of salen-bridged bis-pillar[1]arenes were conveniently prepared by condensation reaction of5,5'-methylenebis(2-hydroxybenzalde hyde)or 5,5'-(propane-2,2-diyl)bis(2-hydroxybenzaldehyde)with mono-amido-functionalized pillar[5]arenes containing different terminal aminoalkyl groups in refluxing ethanol.The^1H NMR and 2D-NOESY spectra indicated that the salen-bridged bis-pillar[5]arenes with longer allcylene linker(n=3,4,6)formed the fascinating bis-[1]rotaxanes,while the salenbridged bis-pillar[5]arenes with short hydrazine and ethylenediamino linker(n=0,2)predominately existed in free form.The single crystal structure of the bis-pillar[5]are ne ambiguously indicated that two propylenediamino linker inserted in to two cavities of pillar[5]arene to form a novel bis-[1]rotaxanes. 相似文献
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Cai-Li Sun Jiang-Fei Xu Yu-Zhe Chen Li-Ya Niu Li-Zhu Wua Chen-Ho Tung Qing-Zheng Yang 《中国化学快报》2015,26(7):843-846
A new monofunctionalized pillar[5]arene bearing imidazolium moiety that formed stable [1]pseudorotaxane even at high concentration (100 mmol/L) was reported. [1]Rotaxane was obtained effi ciently through thiol-ene reaction from [1]pseudorotaxane which further confi rmed the formation of [1]pseudorotaxane. 相似文献
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A. Hajri R. Abderrahim 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3):520-525
Abstract The reaction of thionyl chloride with amidines 2, derived from N-benzimidazol-2-yl imidates 1, leads to [1,2,4,6]thiatriazino[2,3-a][1,3]benzimidazol-1(2H)-one 3 in good yields. [1,3,5]Thiadiazino[3,4-a][1,3]benzimidazol-2-imine 4 was prepared by condensation of NaSCN with benzimidazol-2-yl imidate 1. The isolated compounds 3 and 4 were identified by spectroscopic methods including IR, 1H NMR, and 13C NMR as well as elemental analyses and MS of 3d and 4b. GRAPHICAL ABSTRACT 相似文献
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Ahmed A. El-Maghraby Gameel A. M. El-Hag Ali Ahmed H. A. Ahmed Mohamed S. A. El-Gaby 《Phosphorus, sulfur, and silicon and the related elements》2013,188(2):293-302
Ternary condensation of aromatic aldehydes, malononitrile and thioglycolic acid (2:2:1 molar ratio) in ethanol/piperidine afforded the corresponding thiazolo[3,2-a]pyridines 1a-d . Thiazolo[2',3':1,6]pyrido[2,3-d]pyrimidine 4 was obtained by refluxing of compound 1a with acetic anhydride. Also, thiazolopyrido pyrimidine 6 was produced by refluxing of 1a with triethylorthoformate followed by treatment with hydrazine hydrate. Refluxing 1a with formic acid yielded the thiazolopyridopyrimidine 8 which on chlorination with thionyl chloride furnished the chloro derivative 9 . Finally, amino thiazolo[2',3':1,6]pyrido[2,3-d]pyrimidine 10 was obtained by treatment of 1a with formamide. The structures of these compounds were established on the basis of elemental analyses, IR, 1 H NMR, and mass spectral data. Also, the antimicrobial activity of some synthesized compounds is reported. 相似文献
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The reaction of 3-allylthio-5-phenyl-4H-1,2,4-triazole with iodine to give a mixture of 5,6-dihydro-5-iodomethyl-3-phenyl[1,3]thiazolo[2,3-c][1,2,4]triazole, 6,7-dihydro-6-iodo-3-phenyl-5H-[1,2,4]triazolo[3,4-b][1,3]thiazine, 5,6-dihydro-6-iodomethyl-2-phenyl[1,3]thiazolo[3,2-b][1,2,4]triazole, and 6,7-dihydro-6-iodo-2-phenyl-5H-[1,2,4]triazolo[5,1-b][1,3]thiazine has been studied. The structure of the products obtained was established using 1H NMR spectroscopy of their dehydriodination products. 相似文献