Achromatic customized intraocular lens based on an individual pseudophakic eye model

Customized hybrid diffractive-refractive intraocular lens (IOL) has been designed based on an individual pseudophakic eye model constructed with the measured corneal topography data and the eye's axial lengths. The detailed designing and optimizing procedure is given. It is found that an eye with achromatic customized IOL would achieve super modulation transfer function (MTF) in both the scotopic and photopic conditions. The variation of MTF as colors is negligible, the chromatic focus shift is no more than 0.1 D, and the depth of focus is 3.0 D with quite high MTF. The achromatic customized IOL provides excellent visual performance for cataract patients. Moreover, individual pseudophakic eye model can be an effective tool for evaluating the optical performance of pseudophakic eye and the influence of clinical surgery deviation.     

Analysis of Purkinje images as an effective method for estimation of intraocular lens implant location in the eyeball

The implantation of an artificial intraocular lens (IOL) into a capsular bag in place of an extracted natural, but nontransparent lens is a standard therapy method in the case of cataract. Any decentration or tilt of the IOL can cause a deterioration of the retinal image quality, thus decreasing the vision quality. The analysis of the relative position of Purkinje images being a reflection of the point light source from the refracting surfaces of the eyeball determines the location of IOL inside the eye and thus enables to state its wrong or correct location. The paper describes the Purkinje experimental setup consisting of an illuminator (several infrared LEDs arranged in a circle), an imaging telecentric lens and image recording CCD camera and reports details of the system calibration The usefulness of the experimental setup has been proven both in laboratory conditions using artificial model of the eyeball and in measurements on human subjects. Simulations of the retinal image with different decentrations or tilts are shown.     

人工晶体倾斜与偏心对人眼视功能的影响

基于Hwey-Lan Liou人眼生理模型,采用光线追迹的方法,分析了相同孔径下具有不同球差的人工晶体(IOL)在眼内的倾斜和偏心对人眼视功能的影响.IOL在眼内无倾斜和偏心时,负球差IOL对人眼视功能的改善优于无球差IOL和传统的正球差IOL;当IOL在眼内倾斜,偏心程度一定时,负球差IOL球差值越大,其倾斜和偏心对人眼视功能的降低越明显;植入无球差IOL的眼的视功能受其倾斜和偏心的影响较小,在IOL偏心1.0 mm,倾斜10°已使人眼有明显视觉不适的情况下,仍能表现出良好的光学性能,对人眼视功能的改善不仅优于正球差IOL,而且优于负球差IOL.     

Modification of hydrophobic acrylic intraocular lens with poly(ethylene glycol) by atmospheric pressure glow discharge: A facile approach

To improve the anterior surface biocompatibility of hydrophobic acrylic intraocular lens (IOL) in a convenient and continuous way, poly(ethylene glycol)s (PEGs) were immobilized by atmospheric pressure glow discharge (APGD) treatment using argon as the discharge gas. The hydrophilicity and chemical changes on the IOL surface were characterized by static water contact angle and X-ray photoelectron spectroscopy to confirm the covalent binding of PEG. The morphology of the IOL surface was observed under field emission scanning electron microscopy and atomic force microscopy. The surface biocompatibility was evaluated by adhesion experiments with platelets, macrophages, and lens epithelial cells (LECs) in vitro. The results revealed that the anterior surface of the PEG-grafted IOL displayed significantly and permanently improved hydrophilicity. Cell repellency was observed, especially in the PEG-modified IOL group, which resisted the attachment of platelets, macrophages and LECs. Moreover, the spread and growth of cells were suppressed, which may be attributed to the steric stabilization force and chain mobility effect of the modified PEG. All of these results indicated that hydrophobic acrylic IOLs can be hydrophilic modified by PEG through APGD treatment in a convenient and continuous manner which will provide advantages for further industrial applications.     

人工晶体前移与人眼屈光调节关系的研究

基于Hwey-Lan Liou眼模型,采用ZEMAX光学设计软件实现光线追迹的方法研究了人工晶体在眼内的前移与人眼屈光调节之间的关系.结果表明：人工晶体每前移一定的距离,人眼所获得的屈光调节量不恒定;调节量大小依赖于眼轴长度和所需植入的人工晶体,特别是眼轴长度;对于不同眼轴长度术眼中的人工晶体前移,人眼所获得的屈光调节量与眼轴长度呈负相关.     

Effect of crystalline lens surfaces and refractive index on image quality by model simulation analysis

The surfaces and refractive index of crystalline lens play an important role in the optical performance of human eye.On the basis of two eye models,which are widely applied at present,the effect of lens surfaces and its refractive index distribution on optical imaging is analyzed with the optical design software ZEMAX (Zemax Development Co.,San Diego,USA).The result shows that good image quality can be provided by the aspheric lens surfaces or (and) the gradient-index (GRIN) distribution.It has great potential in the design of intraocular lens (IOL).The eye models with an intraocular implantation are presented.     

Eye models for the prediction of contrast vision in patients with new intraocular lens designs

Theoretical calculations of the polychromatic modulation transfer function (MTF) and wave-front aberration were performed with physiological eye models. These eye models have an amount of spherical aberration that is representative of a normal population of pseudophakic eyes implanted with two different types of intraocular lens (IOL) made from high-refractive-index silicone. These theoretical calculations were compared with the measured contrast sensitivity function (CSF) under mesopic lighting conditions and with wave-front aberration (obtained with a Hartmann-Shack wave-front sensor) collected from 37 patients bilaterally implanted with the same types of lens. The relationships between the ocular wave-front aberration and the MTF predicted by the eye models and the CSF and the ocular wave-front aberration measured in eyes implanted with IOLs were investigated. The predicted improvements in MTF and wave-front aberration correlated well with the improvements measured in practice. Physiological eye models are therefore useful tools for IOL design.     

Innovative confocal laser method for exact dioptric power measurement of intraocular lens implants Invited Paper

We present a novel confocal laser method (CLM) for precise testing of the dioptric power of both positive and negative intraocular lens (IOL) implants. The CLM principle is based on a simple fiber-optic confocal laser design including a single-mode fiber coupler that serves simultaneously as a point light source used for formation of a collimated Gaussian laser beam, and as a highly sensitive confocal point receiver. The CLM approach provides an accurate, repeatable, objective, and fast method for IOL dioptric power measurement over the range from 0 D to greater than =t=30 D under both dry and in-situ simulated conditions.     

Subjective evaluation of intraocular lenses by visual acuity measurement using adaptive optics

We present a new method for subjectively evaluating intraocular lenses (IOLs) without implantation surgery. To illustrate the method, three types of single-piece IOL (equispherical monofocal, rotational symmetric aspheric monofocal, and diffractive bifocal) were assembled into a model eye and evaluated using an ocular adaptive optics system by a single subject. To separate the spherical aberration of the crystalline lens, the subject's corneal topography and wavefront aberrations were measured and modeled. Three levels of Zernike spherical aberration were generated and superposed on the IOLs and the subject's eye. The corrected distance visual acuity was measured by psychophysical visual procedure.     

菲涅尔波带片-球面结构透镜的成像分析

设计了一种新型的菲涅尔波带片 球面透镜。应用衍射光学方法,从理论上研究了这种透镜的变焦功能和分辨特性。数值结果表明,在衍射空间有两个焦点,改变波带数可以使两个焦点分开任意距离。当波带数足够大时,可以使透射空间只有一个向透镜方向迁移的焦点。与单一的透镜和单一的波带片相比,这种菲涅尔波带片 球面透镜的横向和纵向分辨率同时得到了提高。因此,这种新型的结构透镜可应用于三维成像。     

Ultrashort laser ablation of PMMA and intraocular lenses

The use of intraocular lenses (IOLs) is the most promising method to restore vision after cataract surgery. Several new materials, techniques, and patterns have been studied for forming and etching IOLs to improve their optical properties and reduce diffractive aberrations. This study is aimed at investigating the use of ultrashort laser pulses to ablate the surface of PMMA and intraocular lenses, and thus provide an alternative to conventional techniques. Ablation experiments were conducted using various polymer substrates (PMMA samples, hydrophobic acrylic IOL, yellow azo dye doped IOL, and hydrophilic acrylic IOL consist of 25% H₂O). The irradiation was performed using 100 fs pulses of 800 nm radiation from a regeneratively amplified Ti:sapphire laser system. We investigated the ablation efficiency and the phenomenology of the ablated patterns by probing the ablation depth using a profilometer. The surface modification was examined using a high resolution optical microscope (IOLs) or atomic force microscope—AFM (PMMA samples). It was found that different polymers exhibited different ablation characteristics, a result that we attribute to the differing optical properties of the materials. In particular, it was observed that the topography of the ablation tracks created on the hydrophilic intraocular lenses was smoother in comparison to those created on the PMMA and hydrophobic lens. The yellow doped hydrophobic intraocular lenses show higher ablation efficiency than undoped hydrophobic acrylic lenses.     

大焦深人工晶体的设计

运用Zemax光学设计软件构建Liou-Brennan眼模型,设计了增大焦深的非球面、折射型多焦点和衍射型多焦点人工晶体,并用点列图和视锐度分析了所设计的人工晶体的光学质量。对于非球面人工晶体,在3mm瞳孔下,当人眼无球差时,最佳视锐度相当高,但焦深仅为1．4m^-1;当人眼球差为0．4λ时,最佳视锐度可达0．9,焦深达2．2m,同时在整个焦深范围内视觉质量均优越。对于衍射型和折射型多焦点人工晶体,在明视条件下,虽然视远和视近时视觉质量良好,但是中间距离的视锐度〈0．5。衍射型多焦点人工晶体只有81％的光能用于成像,远近焦点能量均分,且与瞳孔大小无关;折射型多焦点人工晶体的远近焦点能量与瞳孔大小相关。设计的人工晶体均能增大人眼的焦深,但各有优缺点,临床上应该酌情选用。     

大容差光纤耦合技术研究

设计了一种新型的耦合系统,该耦合系统由大口径聚焦透镜、1/4节距自聚焦透镜、锥形光纤和球端光纤四部分组成.分析了自聚焦透镜压缩发散角和球端光纤增大数值孔径的机理,给出了计算锥形光纤参量的详细流程.采用大口径透镜和1/4节距自聚焦透镜有效增大径向位置容差和角度容差,然后通过锥形光纤压缩光束半径将激光耦合进球端光纤.仿真实验结果表明,该系统耦合在r<3 mm,－1<θ<1.5范围内的耦合效率稳定保持在50%以上.     

衍射极限非球面准直透镜

介绍了一种新的非球面透镜设计方法。通过非球面方程中二次曲面常数和非球面系数对光学系统像差的贡献来设计非球面透镜,并详细分析了非球面设计过程。设计了数值孔径NA=0.37, 纤芯Φ=600μm的大光束光纤耦合半导体激光器的非球面准直透镜,其焦距f=50mm。从像质评定可以看出, 非球面准直镜几乎接近衍射极限, 整个系统的波像差小于0.3λ。实验表明： 采用非球面准直系统能最大限度地利用光能率和提高光束准直性, 证明了设计方法基本正确。     

A novel approach to design intraocular lenses with extended depth of focus in a pseudophakic eye model

Eye model is firstly used to design and assess the performance of intraocular lenses (IOLs) with extended depth of focus (DOF), including aspherical IOL, refractive multifocal IOL and diffractive multifocal IOL. The details of design and optimization are given, and the optical performance of the pseudophakic eye with the designed IOLs is assessed with the spot diagram and the visual acuity. For the pseudophakic eye with 3 mm pupil, when the spherical aberration is fully corrected by the aspherical IOL, the best visual acuity reaches 1.2 with a DOF of only 1.4D. Whereas when the spherical aberration is 0.4λ, the best visual acuity is 0.9 with a DOF as much as 2.2D. With the implantation of refractive or diffractive multifocal IOL, the pseudophakic eye has fairly good distant and near vision, while the intermediate vision is worse. Diffractive multifocal IOL diverts 81% of the input light to two primary focuses equally, with the additional 19% of the light wasted as higher order diffraction. Refractive multifocal IOL diverts all the light to two focuses but the light distribution varies with the pupil diameter.     

Diffractive lens with binary phase levels to generate two focuses

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Experiments and analyses of a new type optical system for computed radiography

A new high-performance laser scanning system is designed. In this system, a scanning arm consisting of a pentagonal prism and a scanning object lens is used to replace the traditional Fθ lens, and a circular imaging plate transmission mechanism is specially designed in order to meet the requirement of the scanning arm. At the same time, the stimulation fluorescence can be obtained by the scanning arm. Some main factors that influence the spatial resolution and the performance of the laser scanner system are analyzed, and the analysis results are presented, which is helpful for further optimization design of the system. Experimental results indicate that the images obtained by the system have good visual effects and can meet the requirements of industrial inspection.     

Annular-focus zone lens for increasing the intensities of created Bessel beams

In this paper we proposes a new concept of annular-focus zone lens and its design procedure based on binary optics. An investigation of the diffraction efficiencies and the transverse intensity distributions on the focal plane of the designed annular-focus zone lenses is presented. This special kind of zone lens may be used to increase the intensities of Durnin's diffraction-free beams.     

水平场景无畸变折反射全景成像系统透镜畸变的消除

采用短焦距透镜设计水平场景无畸变折反射全景成像系统,会使系统更加小型化,然而短焦距透镜的畸变会对系统成像产生影响。为此建立了具有径向畸变的相机模型;根据这一相机模型,研究了采用短焦距摄像头的水平场景无畸变折反射全景成像系统中,透镜畸变对系统成像的影响,结果表明短焦距透镜的畸变会对系统成像产生严重影响;为了消除透镜畸变的影响,对反射镜的设计进行了改进,在反射镜面形微分方程中包含了透镜畸变消除的参量;按新的方法,设计了一套由短焦距摄像头组成的水平场景无畸变折反射全景成像系统。     

头盔式单目微光夜视仪中光学系统的设计

为提高头盔式单目微光夜视仪中光学系统的成像质量，并满足夜视仪结构紧凑、质量小的指标要求，提出在微光夜视仪光学系统设计中引入高次项非球面透镜的设计方法。针对具体的头盔式微光夜视仪，根据微光物镜、目镜系统技术参数计算理论，确定该微光夜视仪光学系统的技术参数，应用光学设计软件ZEMX上机调试，并在光学系统设计中引入高次非球面透镜，使物镜系统镜片数由原来的9片减少为6片，目镜系统由原来的9片减少为7片，简化了结构，并提高了成像质量。设计结果表明：在头盔式微光夜视系统中采用非球面透镜可以提高系统成像质量，简化系统结构。