三氟乙烯基芳基醚的合成

三氟乙烯基芳基醚;四氟二溴乙烷;酚;三氟乙烯基芳基醚的合成     

From Anilines to Aryl Ethers: A Facile,Efficient, and Versatile Synthetic Method Employing Mild Conditions

We have developed a simple and direct method for the synthesis of aryl ethers by reacting alcohols/phenols (ROH) with aryl ammonium salts (ArNMe₃⁺), which are readily prepared from anilines (ArNR′₂, R′=H or Me). This reaction proceeds smoothly and rapidly (within a few hours) at room temperature in the presence of a commercially available base, such as KO^tBu or KHMDS, and has a broad substrate scope with respect to both ROH and ArNR′₂. It is scalable and compatible with a wide range of functional groups.     

Short and Efficient Synthesis of Thiol Group Functionalized Crown Ethers

A synthesis of thiol group functionalized crown ethers is reported. The reaction is accomplished by the direct chlorosulfonation of simple crown ethers with chlorosulfonic acid and the reduction of the sulfonyl chloride moiety with LiAlH₄ in two steps. This new process is simple to operate, and it generates high‐purity mercaptobenzocrowns with excellent yields.     

A Facile Synthesis of Aryl Ethers of Ethynyl-Carbinols Using the Mitsunobu Reaction

The facile synthesis of a few aryl ethers of ethynyl carbinols using the Mitsunobu reaction is reported.     

Free Radical Hydrophosphorylation of Fluoroalkyl Vinyl Ethers: Synthesis of Fluoroalkyl Phosphonates

An effective method for the synthesis of dialkyl [2-(polyfluoroalkoxy)ethyl]phosphonates by free radical hydrophosphorylation of fluoroalkyl vinyl ethers with dialkyl (H)-phosphonates was developed. The reaction proceeds in the presence of catalytic amounts of azabisisobutyric acid dinitrile (AIBN) (150°C, 2 h, portionwise addition of AIBN) to afford the target fluoroalkyl phosphonates in up to 85% isolated yield.     

A Convenient and Efficient Procedure for Oxime Ethers

In connection with our asymmetric reduction research, we are of interest to synthesize ketoxime ethers because they give good enantioselectivty in the reduction system of Lewis acid-NaBH4-Ligand1. In the literature the oxime ethers were made under anhydrous conditions using strong base such as NaH or sodium alkoxides to realize the substitution reaction between alkyl halide and oxime2. The reaction has also been performed under PTC conditions3. There were cases where the yields were low…     

Addition of Nitrile Oxides to Aryl Allyl Ethers

3,5-Disubstituted isoxazolines with an aryloxymethyl group in position 5 have been synthesized. The [2+3] cycloaddition reaction of benzonitrile oxide to a 5-chlorosalicylic acid derivative containing two allyl groups occurs to give a compound with an oxazolinylmethyl fragment both in the ester and the ether parts of the molecule. The addition of nitrile oxides to the aryl allyl ethers occurs regiospecifically to give the 5-substituted isomer.     

端烯丙基冠醚的合成

从邻苯二酚出发合成了两种未见文献报道的环上含有端烯丙基的冠醚化合物。这两种冠醚的结构均经元素分析、ＩＲ、￣１ＨＮＭＲ和ＭＳ所证实。两种冠醚分别与有机硅化合物聚合制备的气相色谱固定相，在分离酚类和二硝基甲苯类异构体方面具有极好的选择性。     

杂芳基烷基醚、杂芳基卤化物与(氘代)醇的亲核醚化

研究了在叔丁醇钾的作用下,杂芳基烷氧化合物、杂芳基卤化物和杂芳基硫醚与各种伯、仲、叔脂肪醇高效醚化,强调了天然产物和生物活性分子的衍生化以及不易通过其他途径获得的氘代芳基烷基醚的合成方法的实用性.     

New Type of Lariat Ethers: Synthesis and Cation Binding Ability of Phosphonoalkyl-Azacrown Ethers

The synthesis of azacrown ethers with phosphonoalkyl side chains of two to five carbon atoms ( 3–8, 10), potentially useful as a new type of cation binding agent, is described. Introduction of the phosphonoalkyl moiety into the parent monoaza-15-crown-5 ( 1) decreases the cation extraction ability, but results in an increase in the selectivity towards the cations examined. The effect of the phosphonoalkyl-azacrown ethers on the properties of membranes used in ion-selective electrodes is also reported.     

A Facile and Efficient Synthesis of N,N—Dimethylarylamines from Aryl Bromides

Catalytie amination of aryl bromides with in situ generated dimethylamines from N,N-dimethylacetamide(DMA)has been suceessfully carried out using Ni(phen)Cl2 as catalyst,Both electron-rich and electron-poor aromatie system reaeted smoothly under the conditions to give N,N-dimethylarylamines in good yields.     

Room-Temperature Bismuth-Catalyzed Bis-arylation of Carbonyl Compounds with Aryl Ethers and Phenols

Using Bi2（SO4）3 as the catalyst and TMSCl as the additive, a wide variety of aldehydes, ketones, and acetals were smoothly condensed with aryl ethers at room temperature to provide the corresponding diarylmethanes and triarylmethanes selectively in good to excellent yields.     

A Facile One-pot Method for the Synthesis of Vinyl Ethers from 2-Hydroxyalkyl Phenyl Selenides

chloride instead of primary or secondary organic halide, only 21% isolated yield of 1-tert-butoxy-1-phenylethene was obtained. Obviously, t-butyl chloride would tend to mainly take place the elimination reaction rather than the substitution reaction under sodium alkylate. Scheme 1 R1OHPhSe R2R3CHX 2NaH/THFR1OPhSeCHR2R3R1 OCHR2R3H2O21 3 4 Table 1 Preparation of vinyl ethers from 2-hydroxyalkyl phenyl selenides Entry R1 R2R3X Product a Yield (%) b 1 C6H5 CH2=CHCH2Br 4a 83 …