共查询到20条相似文献,搜索用时 15 毫秒
1.
Amaryllidaceae Alkaloids from Lycoris radiata 总被引:1,自引:0,他引:1
Tao Feng Yuan‐Yuan Wang Jia Su Yan Li Xiang‐Hai Cai Xiao‐Dong Luo 《Helvetica chimica acta》2011,94(1):178-183
A phytochemical investigation on bulbs of Lycoris radiata resulted in the isolation of three new Amaryllidaceae alkaloids, named 5,6‐dehydrodihydrolycorine ( 1 ), 6β‐acetoxycrinamine ( 2 ), and (+)‐8‐O‐acetylhomolycorine α‐N‐oxide ( 3 ), together with eleven known alkaloids, 4 – 14 . The structures of the new alkaloids were established by means of spectroscopic methods, and the known compounds were identified by comparison of their data with those in the literature. Compound 2 showed cytotoxicity against HL‐60, A‐549, and MCF‐7 cells, with IC50 values of 8.1, 24.3, and 15.0 μM , respectively. 相似文献
2.
Giordani RB de Andrade JP Verli H Dutilh JH Henriques AT Berkov S Bastida J Zuanazzi JA 《Magnetic resonance in chemistry : MRC》2011,49(10):668-672
The Amaryllidaceae family has proven to be a rich source of active molecules. As part of an ongoing project, we report a phytochemical study of Hippeastrum morelianum (Amaryllidaceae), from which we have isolated two homolycorine-type alkaloids, the new 2α,7-dimethoxyhomolycorine (1) and the poorly described candimine (2), as well as six known alkaloids: tazettine, pretazettine, 3-epimacronine, haemanthamine, hamayne and trisphaeridine. For reference purposes, the NMR of the isolated compounds was unequivocally described, based on 2D NMR measurements including (1)H-(1)H COSY, (1)H-(1)H NOESY, HSQC and HMBC. 相似文献
3.
Cabezas F Ramírez A Viladomat F Codina C Bastida J 《Chemical & pharmaceutical bulletin》2003,51(3):315-317
Thirteen alkaloids have been isolated from dried bulbs and leaves of flowering Eucharis amazonica (Amaryllidaceae). The alkaloids, 7-methoxyoxoassoanine, 6-O-methylpretazettine and apohaemanthamine, are reported for the first time from a natural source. 相似文献
4.
5.
6.
Jucimar J. de Souza Leda Mathias Raimundo Braz‐Filho Ivo J. Curcino Vieira 《Helvetica chimica acta》2010,93(3):422-429
Two new monoterpene indole alkaloids named ibogamine‐7,8‐dione ( 1 ) and 12‐methoxyvoachalotine ( 2 ), and eight known ones, coronaridine ( 3 ), coronaridine hydroxyindolenine ( 4 ), 5‐oxocoronaridine ( 5 ), 3‐oxocoronaridine hydroxyindolenine ( 6 ), 3‐oxocoronaridine ( 7 ), vobasine ( 8 ), ibogamine ( 9 ), and olivacine ( 10 ), were isolated from a CH2Cl2 extract of the root bark from Tabernaemontana hystrix. The structures of the compounds were elucidated on the basis of spectroscopic data analyses, mainly 1H‐ and 13C‐NMR, including 2D experiments (1H,1H‐COSY, HMBC, and HMQC). 相似文献
7.
8.
Daniel Zaragoza-Puchol Javier E. Ortiz Alejandro A. Orden Marianela Sanchez Jorge Palermo Alejandro Tapia Jaume Bastida Gabriela E. Feresin 《Molecules (Basel, Switzerland)》2021,26(1)
Plants in the Amaryllidaceae family synthesize a diversity of bioactive alkaloids. Some of these plant species are not abundant and have a low natural multiplication rate. The aims of this work were the alkaloids analysis of a Habranthus cardenasianus bulbs extract, the evaluation of its inhibitory activity against cholinesterases, and to test several propagation strategies for biomass production. Eleven compounds were characterized by GC-MS in the alkaloid extract, which showed a relatively high proportion of tazettine. The known alkaloids tazettine, haemanthamine, and the epimer mixture haemanthidine/6-epi-haemanthidine were isolated and identified by spectroscopic methods. Inhibitory cholinesterases activity was not detected. Three forms of propagation were performed: bulb propagation from seed, cut-induced bulb division, and micropropagated bulbs. Finally, different imbibition and post-collection times were evaluated in seed germination assays. The best propagation method was cut-induced bulb division with longitudinal cuts into quarters (T1) while the best conditions for seed germination were 0-day of post-collection and two days of imbibition. The alkaloids analyses of the H. cardenasianus bulbs showed that they are a source of anti-tumoral alkaloids, especially pretazettine (tazettine) and T1 is a sustainable strategy for its propagation and domestication to produce bioactive alkaloids. 相似文献
9.
10.
11.
12.
13.
14.
15.
Shuang LIANG Xin Gen LUO Hai Sheng CHEN? Xiao Dong ZHANG Mao HUANG Wen Yong LIU College of Pharmacy Second Military Medical University Shanghai Department of Pharmacy Guangzhou Military General Hospital Guangzhou Center of New Drug Evaluation Institute of Basic Medical Sciences Second Military Medical University Shanghai 《中国化学快报》2006,(6)
The non-alkaloid chemical constituents, which were isolated from the stems of Ervatamia yunnanensis Tsiang (Apocynaceae), have been reported in previous paper 1. As a part of our continuing research on the isolation of active compounds for anti-addictive … 相似文献
16.
17.
Marco Masi Roberta Di Lecce Alessio Cimmino Antonio Evidente 《Molecules (Basel, Switzerland)》2020,25(23)
Amaryllidaceae are bulbous wild and cultivated plants well known for their beautiful flowers and pharmaceutical applications, essentially due to the alkaloids and flavonoids content. Hundreds of alkaloids have been isolated until now and several scientific publications reported their sources, chemical structures, and biological activities. During the last decade, some unstudied Amaryllidaceae plants were the object of in-depth investigations to isolate and chemically and biologically characterize new and already known alkaloids as well as some analogues. This review describes the isolation and chemical and biological characterization of the Amaryllidaceae alkaloids, and their analogues obtained in the last decade, focusing the discussion on the new ones. 相似文献
18.
Acotoxinine ( 1 ), a new norditerpene alkaloid, was isolated from the roots of Aconitum toxicum Rchb ., together with the structurally related C19 diterpene alkaloids neoline ( 2 ) and aconitine ( 3 ) and C20 diterpene alkaloids songorine ( 4 ) and songoramine ( 5 ). The structures were elucidated by HR‐MS and advanced NMR methods, including 1H‐NMR, JMOD, 1H,1H‐COSY, HSQC, and HMBC experiments. This is the first report of C20 diterpenoid alkaloids in Aconitum toxicum. 相似文献
19.
Yadan Wang Jiangong Yan Zhongmou Zhang Minghui Chen Xianfu Wu Shuangcheng Ma 《Molecules (Basel, Switzerland)》2022,27(21)
Tripterygium wilfordii Hook. f. is a well-known traditional Chinese medicine used to treat autoimmune diseases. Sesquiterpene pyridine alkaloids (SPAs) are a major class of components found in this herb that have piqued the interest of researchers due to their complex and diverse structures as well as significant biological activities. In this study, ten new SPAs, wilfordatine A–J (1–10), were isolated from the roots of T. wilfordii, along with ten known analogues (11–20). Their structures were primarily elucidated by extensive 1D and 2D NMR spectroscopic analysis. To search for more immunosuppressive ingredients related to the clinical efficacy of T. wilfordii, the total alkaloids (TA) and compounds 4, 5, and 9–16 were tested for their inhibitory effects on nuclear factor-kappa B (NF-κB) pathway in Lipopolysaccharide (LPS) induced HEK293/NF-κB-Luc cells. Among them, TA, compounds 5, 11, and 16 showed potent immunosuppressive activity, with IC50 values of 7.25 μg/mL, 8.75 μM, 0.74 μM, and 15.66 μM, respectively, and no influence on the cell viability at a concentration of 100 μg/mL (TA) or 100 μM (5, 11, and 16). Accordingly, TA, 5, 11, and 16, especially 11, were identified as promising candidates for further investigation into their potential use as immunosuppressive agents. 相似文献