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1.
P. S. Silaichev N. V. Kudrevatykh Z. G. Aliev A. N. Maslivets 《Russian Journal of Organic Chemistry》2012,48(2):253-256
1-Aryl-4,5-diaroyl-1H-pyrrole-2,3-diones react with styrene to form substituted 7,7a-dihydropyrano[4,3-b] pyrrole-2,3(1H,6H)-diones whose structure was confirmed by XRD analysis. The crystal and molecular structure of 7a-(2,5-dimethylbenzoyl)-4-(2,5-dimethyl-phenyl)-1-(4-methoxyphenyl)-6-phenyl-7,7a-dihydropyrano[4,3-b] pyrrole-2,3(1H,6H)dione was examined. 相似文献
2.
An auto oxidation-rearrangement product 4 was isolated from a high dilution reaction of ninhydrin with 3,4,5-trimethoxyaniline in water. A general synthesis of this compound and its derivatives 4–6 was devised by oxidation of tetrahydroindeno[1,2-b]indol-10-ones 1–3 with sodium periodate to give isoindolo[2,1-a]-indole-6,11-diones 4–6 in good yield. Compounds 4–6 can be easily transformed into spiro[1H-isobenzofuran-1,2′-2H-indole]-3,3′-diones 8–10 , spiro[2H-indole-2,1′-1H-isoindole]-3,3′-diones 11–13 and isoindole[1,2-a:2′,1′-b]pyrimidine-5,15-diones 15, 16 in high yields. Analogous reactions were performed on 3-amino-5a, 10a-dihydroxybenzo[b]indeno[2,1-d]furan-10-one ( 17 ) to give a dibenzoxocintrione 18 , spiro-[benzofuran-2,1′-isobenzofuran]-3,3′-dione 19 and an isoindol-1-one 20 . 相似文献
3.
The syntheses of the K-oxides and K-imine derivatives of benzo[b]phenanthro[2,3-d]thiophene and benzo-[b]phenanthro[3,2-d]thiophene are described. The parent hydrocarbons 1 and 2 were oxidized with osmium tetroxide and sodium metaperiodate, and the dialdehydes 12 and 18 so formed, cyclized to the corresponding epoxides 1a,12b-dihydrobenz[b]oxireno[9,10]phenanthro[2,3-d]thiophene ( 7 ) and 1a,12b-dihydrobenz-[b]oxireno[9,10]phenanthro[3,2-d]thiophene ( 13 ). Reaction of the oxiranes with sodium azide gave mixtures of azido-alcohols that, in turn, were transformed to the thiaarene imines 1a,12b-dihydro-1H-benz[b]azirino-[9,10]phenanthro[2,3-d]thiophene ( 8 ) and 1a,12b-dihydro-1H-benz[b]azirino[9,10]phenanthro[3,2-d]thiophene ( 14 ), respectively, with the aid of tri-n-butylphosphine. 相似文献
4.
The conversion of 2-acylamino-3-amino-1,4-naphthoquinones (II) to the corresponding 2-substituted 1H-naphth[2,3-d]imidazole-4,9-diones (I) under both alkaline and acid catalyzed conditions has been effected and the results compared. Treatment of 3-(4′-chlorobutanonyl-amino)-3-amino-1,4-naphthoquinone (He) with aqueous ethanolic sodium hydroxide solution gives 1,2-butanonaphth[2,3-d]imidazole-4,9-dione (V); whereas, treatment of lie with refluxing formic acid gave 2-(4′-chlorobutyl)-1H-naphth[2,3-d]imidazole-4,9-dione. Treatment of 2-substi-tuted 1H-naphth[2,3-d]imidazole-4,5-diones in DMF with alkyl halides in the presence of potassium carbonate affords the expected 1,2-disubstituted naphth[2,3-d]imidazole-4,9-diones (VI). The spectral properties of I, II, V and VI as well as those of some 2-acylamino-3-chloro-1,4-naphthoquinones IV are discussed. 相似文献
5.
The synthesis of 1,3,4,6-letrahydro-6-metliy]-2H,5H-[1,4]diazepino[6,5-b] indole-2,5-diones and 5-phenyl-3,6-dihydro[1,4]diazepino[6,5-b ]indole-2(lH)one is described. Also detailed is the, preparation of a 3-amino-2-benzoylindole. 相似文献
6.
Marjo Merslavi
Andrej Petri
Branko Stanovnik Miha Tiler 《Journal of heterocyclic chemistry》1989,26(3):581-583
The transformations of 7-methyl-7H- and 8-methyl-8H-pyrazolo[4, 3-d]tetrazolo[1, 5-b]pyridazines 1, 2, 9 and 10 into 8-methyl-8H- and 9-methyl-9H-pyrazolo[3, 4-H]-s-triazolo[4, 3-b]pyridazines 7 and 8 , and 1-methyl-1H-and 2-methyl-2H-imidazo[1, 2-b]pyrazolo[3, 4-d]pyridazines 13 and 14 are described. 相似文献
7.
F. Guerrera L. Salerno M. C. Sarv M. A. Siracusa 《Journal of heterocyclic chemistry》1995,32(2):591-594
The synthesis of novel 1-alkyl or 1-aryl-2-(4-substituted-1-piperazinyl)-1-H-benzothieno[2,3-d]imidazoles 7e-x starting from 2-nitro-3-bromobenzo[b]thiophene is described. These compounds were prepared as potential H1-antihistaminic agents. 相似文献
8.
The synthesis and characterization of a number of 3-aryl-6H-isoxazolo[3,4-d]pyrazolo[3,4-b]pyridines and 3-aryl-6H-isoxazolo[5,4-d]pyrazolo[3,4–6]pyridines from common precursors, 5-benzoyl-4-chloro-1H-pyrazolo-[3,4-b]pyridines, has been described. The structures were determined by unambiguous chemical synthesis and by isolation and 13C nmr analysis of some key, isolated, intermediates. The ability of these compounds to displace [3H]flunitrazepam from CNS binding sites was also observed. 相似文献
9.
Tsuneo Itoh Ikuko Fujii Yasuo Tomii Ichiro Ishikawa Hamo Ogura Yoshihisa Mizuno Norio Kawahara 《Journal of heterocyclic chemistry》1987,24(5):1453-1455
An improved and efficient synthesis of 1,3-dialkylpyrido[2,3-d]pyrimidine-2,4-(1H,3H)-diones from 6-methylaminouracils and methyl propiolate or diethyl ethoxymethylenemalonate is described. 相似文献
10.
Several pyridazines have been prepared as intermediates in the synthesis of monosubstituted imidazo[4,5-d]pyridazines, monosubstituted v-triazoIo[4,5-d]pyridazines and monosubstituted pyrazino [2,3d] pyridazines. The new ring system, 7H-imidazo[4,5-d]tetrazolo[l,5-b] pyridazine (XIV) has been prepared unsubstituted. Furthermore, unsubstituted imidazo[4,5-d]pyridazine (XI) has been prepared. Calculations for XI and XIV were made by approximate SCF LCAO-MO with CNSO II theory. 相似文献
11.
Yoshinori Tominaga Lyle W. Castle Raymond N. Castle 《Journal of heterocyclic chemistry》1996,33(4):1319-1321
Photocyclization of the substituted 2-([1]benzothien-3-yl)-3-phenylpropenoic acids 3a-c in the presence of iodine and air in a benzene-cyclohexane mixture afforded a separable mixture of three compounds, benzo[b]naphtho[2,1-d]thiophene-6-carboxylic acids 4a-c , 6H-benzo[b]naphtho[2,3-d]thiopyran-6-ones 5a-c , and 10-methoxy-2-methyl-6H-benzo[b]naphtho[2,3-d]pyran-6-one ( 6 ). 相似文献
12.
Otohiko Tsuge Taizo Hatta Hisashi Kojima Nobutaka Miyahara Masafumi Sugaya 《Journal of heterocyclic chemistry》1994,31(5):1283-1287
2-Benzoyl- 5 and 2-acetylacenaphthenone 6 , prepared from the corresponding 1-acyl-2-(1-pyrrolidinyl)-acenaphthylenes 2 and 3 , reacted with arylhydrazines 8 under acidic conditions to give the corresponding 1-arylacenaphtho[1,2-d]pyrazoles 9 and 10 . Novel heteropentalene mesomeric betaines, 5,7-dehydro-5H,7H-benzo[b]acenaphtho[1,2-e]-1,3a,6a-triazapentalenes 13 and 14 were prepared by reductive cyclization of 1-(o-nitrophenyl)acenaphtho[1,2-d]pyrazoles 9d and 10d , respectively. 相似文献
13.
Kazuhiro Kobayashi Hideo Tanaka Koujirou Tanaka Keiichi Yoneda Osamu Morikawa Hisatoshi Konishi 《合成通讯》2013,43(23):4277-4291
The reaction of 1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione with various alkenes or terminal alkynes in the presence of cerium(IV) ammonium nitrate (CAN) afforded the corresponding 5,6-dihydrofuro[2,3-d]pyrimidine-2,4(1H,3H)-diones or furo[2,3-d]pyrimidine-2,4(1H,3H)-diones in moderate to good yields. 相似文献
14.
Zusammenfassung Intramolekulare Cyclisierungsreaktionen von 3-Phenyl-benzo[b]thiophen-2-carbonsäurechlorid und von 2-Phenyl-benzo[b]thiophen-3-carbonsäurechlorid lieferten 6-Oxo-6H-benz[b]indeno[1,2-d]thiophen bzw. 10-Oxo-10H-benz[b]indeno[2,1-d]thiophen.
3. Mitt.:F. Sauter, Mh. Chem.99, 2100 (1968). 相似文献
Contributions to the chemistry of sulfur containing heterocycles, IV.: 6H-Benzo[b]indeno[1,2-d]thiophene and 10H-benzo-[b]indeno[1,2-d]thiophene
Intramolecular cyclization reactions of 3-phenyl-benzo[b]thiophene-2-carbonyl chloride and of 2-phenyl-benzo[b]-thiophene-3-carbonyl chloride gave 6-oxo-6H-benz[b]indeno-[1,2-d]thiophene and 10-oxo-10H-benz[b]indeno[2,1-d]thiophene, respectively.
3. Mitt.:F. Sauter, Mh. Chem.99, 2100 (1968). 相似文献
15.
Reactions of 5,7-diaryl-1,3-dimethyl-2,4-dioxo-1H,3H-pyrano[4,3-d]pyrimidinium bromides with phenylhydrazines and aromatic acid hydrazides have been studied. The reaction of the salts indicated
with phenylhydrazine at ∼20 °C results in the pyrylium ring opening, whereas elevated temperature leads to recyclization products,
i.e., 1,3-dimethylpyrido[4,3-d]pyrimidine-2,4(1H,3H)-diones. The reactions of the starting bromides with m-carboxyphenylhydrazine and aromatic acid hydrazides lead to 6-(R-amino)-1,3-dimethyl-2,4-dioxo-1H,3H-pyrido[4,3-d]-pyrimidinium salts. 相似文献
16.
Branko Stanovnik Borut Furlan Marko Kupper Lidija Male Anton timac Miha Tiler Marko
li
ar 《Journal of heterocyclic chemistry》1988,25(2):393-398
The nucleophilic and electrophilic substitutions of 6-substituted 9,9-dimethyl-9H-imidazo[1,2-b]pyrazolo- [4,3-d]pyridazines 2 , nucleophilic substitutions of 6-substituted 9,9-dimethyl-9H-pyrazolo[4,3-d]-s-triazolo- [4,3-b]pyridazines 7 and some other transformations to give compounds 3 and 8 , respectively, were studied. It was shown that both heterocyclic systems are stable under the conditions employed in these transformations. 相似文献
17.
A. Shafiee M. A. Ebrahimzadeh J. Shahbazi S. Hamedpanah 《Journal of heterocyclic chemistry》1998,35(1):71-75
Starting from the readily available aryl 2-methyl-5-phenyl-3-furyl ketones, 5-methyl-1H-1-phenylpyrazole-4-yl ketones and 4-methyl-2-phenyl-5-thiazolylcarboxaldehyde, a series of 2-phenyl-4-arylthieno[3,4-b]-furan, 2-phenyl-4-(p-methoxyphenyl)selenolo[3,4-b]furan, 4-aryl-1H-1-phenylthieno[3,4-c]pyrazole and 5-benzyl-2-phenylpyrrolo[3,4-d]thiazole were prepared in high yield. 相似文献
18.
Misbahul Ain Khan Alice Maria Coimbra Rolim Antonio Elydio Guaroni 《Journal of heterocyclic chemistry》1983,20(2):475-476
The synthesis of the parent ring system and some of the derivatives of 1H-pyrazolo[3,4-d]thieno[2,3-b]pyridine are described. 相似文献
19.
Magdi E.A. Zaki A. Paula Bettencourt Francisco M. Fernandes M. Fernanda Proença 《Tetrahedron》2012,68(24):4628-4634
Substituted 4-(2,5-dihydro-1H-pyrrol-3-yl)-1H-imidazoles were prepared from 5-amino-1-aryl-4-cyanoformimidoylimidazoles and cyanoacetamide, under mild experimental conditions. The pyrrolyl-imidazoles were cyclized to the corresponding 7,8-dihydroimidazo[4,5-b]pyrrolo[3,4-d]pyridines by reflux in ethanol, with catalysis by DBU. The same pyrrolyl-imidazoles were reacted with orthoesters, at room temperature and in the presence of sulfuric acid, to generate 3,7-dihydro-8H-imidazo[4,5-d]pyrrolo[3,2-f]diazepines in very good yield. Electrochemical studies of the imidazo[4,5-d]pyrrolo[3,2-f][1,3] diazepine derivatives were carried out. The reduction potential of 7-ethyl-3-(4-methoxyphenyl)-8-oxo-7,8-dihydro-3H-imidazo[4,5-d]pyrrolo[3,2-f][1,3] diazepine-9-carbonitrile was in the adequate range for presenting bioreduction properties. 相似文献
20.
Stirring an equimolar mixture of ninhydrin 1 and 2-aminochromen-4-ones 2 in CH3COOH at room temperature produced 6a,11a-dihydroxy-6H-chromeno[2,3-b]indeno[2,1-d]pyrrole-11,12(6aH,11aH)-diones 3, which on heating with aromatic amines 6 in acetic acid produced 11b-hydroxy-7-N-arylimino-6H-chromeno[2,3-b]isoindolo[1,2-e]pyrrole-12,13(11bH)-diones 7. 相似文献