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1.
A simple method is described to reconstitute membrane receptors into bilayer lipid membranes (BLMs). After reconstitution, the receptor still retains its ligand activity. Furthermore, the relationship between receptor–ligand interactions and electrical properties of reconstituted BLMs such as membrane capacitance (Cm) and membrane resistance (Rm) was studied. When glycophorin in erythrocyte and asialoglycoprotein in hepatocyte were taken as examples, it was found that the resistance of reconstituted BLM decreased when adding blood type monoclonal antibody or the solutions of galactose, respectively, and the decrease is ligand-concentration dependent; however, the membrane capacitance was not influenced. This provides a simple, practical approach to determining the interactions between the receptor and its ligand.  相似文献   

2.
New complexes of cobalt(III) with the tridentate and tetradentate Schiff base ligands: 3-methoxy-2-{(Z)[(2-hydroxyphenyl)imino]methyl}phenol (H2L1), 4-[(2-hydroxyphenyl)imino]-2-pentanone (H2L2); and 2-((E)-1-(2-((E)-1-(2-hydroxy-4,5-dimethylphenyl)ethylideneamino)ethylimino)ethyl)-4,5 dimethylphenol (H2L3), namely [CoIII(L1)(N-MeIm)3]PF6 (1), [CoIII(L1)(py)3]ClO4 (2), [Co(L1)(py)3][Co(L1)2] (3) and [CoIII(L2)(N-MeIm)3]PF6 (4) and [Co(L3)(N-MeIm)2]PF6 (5), were synthesized and characterized by physico-chemical and spectroscopic methods. The crystal structures of the complexes were determined by X-ray crystallography. In each of these complexes, the cobalt(III) centre has a slightly distorted octahedral environment, utilizing all available coordination centres of the ligands. The complexes were also screened for in vitro antibacterial activities against four human pathogenic bacteria, and their minimum inhibitory concentrations indicated good antibacterial activities.  相似文献   

3.
Summary The new complex double saltscw-[Co(NH3)(en)2(H2O)]2 [M(CN)4]3 (en = ethylenediamine; M = Ni, Pd or Pt),cis-[Co(NH3(en)2(H2O)]2[FeNO(CN)5]3 andcis-[Co(NH3)(en)2(H2O)][Co(CN)6] have been synthesized and by anation in the solid state the corresponding new dinuclear complexes with a cyano bridgecis- ortrans-[(NH3)(en)2Co-NC-M(CN)3]2 [M(CN)4] (M = Ni, Pd or Pt);cis-, trans-[(NH3)(en)2Co-NC-FeNO(CN)4]2[FeNO(CN)5] andcis-[(NH3)(en)2Co-NC-Co(CN)5 have been prepared. The complexes have been characterized by chemical analysis, t.g. measurements, and by i.r. and electronic spectroscopy. With [Ni(CN)4][2– and [Co(CN)in]6 3– only thecis-isomer is produced; with [Pd(CN)4]2–, [Pt(CN)4]2– and [FeNO(CN)5]2– thetrans- isomer is the dominant species. The dinuclear complex derived from [Pt(CN)4]2– shows strong Pt-Pt interactions both in the solid state and in solution.  相似文献   

4.
The preparations of cis- and trans-[PtH(C6Cl5)(PEt3)2] by thermal decomposition of cis- and trans-[Pt(OCHO)(C6Cl5)(PEt3)2], respectively, are reported. Also described are cis- and trans-[Pt(SnCl3)(C6Cl5)(PEt3)2], obtained by treating SnCl2 with cis- and trans-[PtCl(C6,Cl5)(PEt3)2], respectively. It is shown that while trans- [PtH(C6Cl5)(PEt3)2] does not form hydride-bridged complexes in the presence of trans-(PtH(MeOH)(PEt3)2]+, the corresponding complex trans-[PtH(C6)(PEt3)2] reacts with the same solvento complex, in methanol, giving labile [(PEt3)2HPt(-μH)Pt(C6F5)(PEt3)2]+.  相似文献   

5.
Black‐brown needle‐shaped single crystals of [Co2(en)4(O2)(OH)][C4O4]1.5 · 4H2O (en = ethylenediamine) were prepared in aqueous solution at room temperature [space group P$\bar{1}$ (no.2) with a = 800.20(8), b = 1225.48(7), c = 1403.84(9) pm, α = 100.282(5), β = 94.515(7), and γ = 95.596(6)°]. The Co3+ cations [Co(1), Co(2)] are coordinated in an octahedral manner by four nitrogen atoms stemming from the ethylenediamine molecules and two oxygen atoms each from a hydroxo group and a peroxo group, respectively. Both Co3+ coordination polyhedra are connected by a common corner and by the peroxo group leading to the dinuclear [(en)2Co(O2)(OH)Co(en)2]3+ cation. The squarate dianions, not bonded to Co3+, and the [(en)2Co(O2)(OH)Co(en)2]3+ cations are linked by hydrogen bonds forming a three‐dimensional supramolecular network containing water molecules. Magnetic measurements revealed a diamagnetic behavior indicating a low‐spin electron configuration of Co3+. The UV/Vis spectra show two LMCT bands [π*(O22–) → dσ*(Co3+)] at 274 and 368 nm and the d–d transition (1A1g1T1g) at 542 nm. Thermoanalytical investigations in air show that the compound is stable up to 120 °C. Subsequent decomposition processes to cobalt oxide are finished at 460 °C.  相似文献   

6.
The crystallization behavior of the title compound, [Co(C2H8N2)3](C2O4)(ClO4)·2H2O, has been studied in order to evaluate the effect of the counter‐anion on the crystalline structures of [Co(en)3](C2O4X (en = ethyl­enedi­amine). Two‐dimensional intermolecular hydrogen‐bonding networks are formed between the amine protons of the [Co(en)3]3+ cations and the O atoms of the oxalate anions. Perchlorate and water mol­ecules fill in the channels between the two‐dimensional networks and form hydrogen‐bonding interactions with the two‐dimensional layers, thus constructing a three‐dimensional hydrogen‐bonding network.  相似文献   

7.
The synthesis and crystal structure of the mononuclear title compound, [Co(C2O4)(C10H8N2)2]·5H2O, is reported. The Co atom is six‐coordinated by two O atoms of a bidentate oxalate group and by four N atoms of two bi­pyridine ligands. The neutral [Co(C2O4)(C10H8N2)2] entities are connected by π–π stacking interactions of the aromatic systems into a two‐dimensional layer, interconnected through a ladder‐like hydrogen‐bonding pattern of solvate water mol­ecules.  相似文献   

8.
Thiazolo[5,4-d]thiazole-2,5-dicarboxylic acid, C6H2N2O4S2, was isolated as a polycrystalline material, and its crystal structure was determined by ab-initio X-ray powder diffraction (XRPD) methods. This species, upon deprotonation, was subsequently used in preparing the new coordination polymers Ag2(C6N2O4S2), Mn(C6N2O4S2)(H2O)2, Co(C6N2O4S2)(H2O)2, Cu(C6N2O4S2)(H2O) and Zn(C6N2O4S2)(H2O)2, fully characterized by analytical, thermal and XRPD structural methods – including in situ thermodiffractometry and simultaneous TGA and DSC. In the first-row transition metal derivatives, the [C6N2O4S2]2? anion systematically prefers the N,O-chelating, vs. the expected O,O′-bridging, coordination mode, not allowing the formation of porous 3D frameworks. Indeed, these species are dense 1D coordination polymers. At variance, the silver derivative possesses a complex, dense 3D framework, due to the presence of μ6-[C6N2O4S2]2? ligands showing two μ2-bridging carboxylates and two monohapto N-donor sites. When dehydration is viable, materials of En(C6N2O4S2) formulation are irreversibly recovered (n = 1 for E = Mn, Co, Zn, Cu; n = 2, for E = H).  相似文献   

9.
[Co(p-toluidine)2(NCS)2] (I), [Co(m-toluidine)2(NCS)2] (II) and [Co(aniline)2(NCS)2] (III) have been synthesized. Kinetic parameters n, E and Z (apparent reaction order, activation energy and pre-exponential factor) have been derived from the TG curves recorded under 12 different working conditions. The influence of the sample weight (mo) and of the heating rate (q) upon the kinetic parameters as well as upon the decomposition temperature and the amount of amine liberated in the first decomposition stage are discussed. Mean values of the activation energy and of the decomposition temperature are discussed in terms of the Co—amine bond strength and molecular structure based on IR evidence.  相似文献   

10.
[Co(R-η-C3H4)(η-C5H5)I] is a good precursor for the preparation of some new cationic complexes as the iodide can easily be replaced; thus addition of PEt3 to the iodo-complex (R  H) gives [Co(η-C3H5)(η-C5H5)(PEt3)]+. The reactions of [Co(R-η-C3H4)(η-C5H5))I] (R  H or 2-Me) with AgBF4 give solutions containing the coordinatively unsaturated species [Co(R-η-C3H4)(η-C5H5)+. The presence of traces of water leads to the formation of [Co(R-ηC3H4)-(η-C5H5)(H2O)]+. The addition of monodentate ligands L  PEt3 PPh3, AsPh3, SbPh3, CNCH3 and bidentate ligands LL  Ph2PCH2CH2PPh2(dppe) and o-C6H4(AsMe2)2(diars), gives, respectively mononuclear [Co(2-Me-ηC3H4)-(η-C5H5)L]+ and binuclear ligand-bridged [(2-Me-ηC3H4)(η-C5H5)CoLLCo(2-Me-ηC3H4)(η-C5H5))]2+ complexes. Crystals of [Co(2-Me-ηC3H4)(η-C5H5)-(H2O)]+[BF4]- are monoclinic, space group P21/c, with a 7.858(3), b 10.262(4), c 15.078(4) Å, β 98.36(1)°. The molecular structure contains the cobalt atom bonded to planar 2-Me-allyl and cyclopentadienyl substituents, which are almost parallel with the H2O molecule in a staggered conformation with respect to the 2-Me group.  相似文献   

11.
The new complexes trans-K[CrF(H2O)(en)2][Co(CN)6] aq. and trans- K[CrF(H2O)(tmd)2][Co(CN)6 aq. (en = ethylenediamine; tmd = 1,3 diaminepropane) have been prepared. The anation reactions have been studied with TG and DSC techniques. The anation reaction gives the new dinuclear species cis K[(aa′)2, FCr-NC-Co(CN)5] (aa′ = en.tmd). The reaction enthalpy of bridge formation has been determined. The activation energy has been calculated by non-isothermal methods.  相似文献   

12.
The oxidative addition of 2-chloropyrimidine or 2-chloropyrazine to [Pd(PPh3)4] yields a mixture of trans-[PdCl(C4H3N2-C2)(PPh3)2] (I) and [PdCl(μ-C4H3N2-C2,N1)(PPh3 (II) (C4H3N2 = 2-pyrimidyl or 2-pyrazyl group). The mononuclear complexes I are quantitatively converted into the binuclear species II upon treatment with H2O2. The reaction of II with HCl gives the N-monoprotonated derivatives cis-[PdCl2(C4H4N2-C2)(PPh3)] (III), from which the cationic complexes trans-[PdCl(C4H4N2-C2)(L) (L = PPh3, IV; PMe2Ph, V; PEt3, VI) can be prepared by ligand substitution reactions. Reversible proton dissociation occurs in solution for III–VI. The low-temperature 1H NMR spectra of trans-[PdCl(C4H4N2-C2)(PMe2Ph)2]ClO4 show that the heterocyclic moiety undergoes restricted rotation around the PdC2 bond and that the 2-pyrazyl group is protonated predominantly at the N1 atom. These results and the 13C NMR data for the PEt3 derivatives are interpreted on the basis of a significant dπ → π back-bonding contribution to the palladium—carbon bond of the protonated ligands.  相似文献   

13.
A tin(II) squarate Sn2O(C4O4)(H2O) was synthesized by hydrothermal technique. It crystallizes in the monoclinic system, space group C2/m (no. 12) with lattice parameters a=12.7380(9) Å, b=7.9000(3) Å, c=8.3490(5) Å, β=121.975(3)°, V=712.69(7) Å3, Z=4. The crystal structure determined with an R=0.042 factor, consists of [(Sn4O10)(H2O)2] units connected from one another in the [101] and [010] directions via squarate groups to form layers separated by Sn(II) lone pairs. This compound presents the same remarkable structural arrangement as observed in the tin-oxo-fluoride Sn2[Sn2O2F4] inorganic compound with Sn(II) lone pairs E(1) and E(2) concentrated in large rectangular-shape tunnels running along [001] direction.  相似文献   

14.
The reactions of [Co(η-C5H5)(L)I2] with Na[S2CNR2] (R = alkyl or phenyl) give [Co(η-C5H5)(I)(S2CNR2)] (I) when L = CO and [Co(η-C5H5)(L)(S2CNR2)]I (II) when L is a tertiary phosphine, phosphite or stibine, or organo-isocyanide ligand. In similar reactions [Co(η-C5H5)(CO)(C3F7)I] gives [Co(η-C5H5)(C3F7)(S2CNMe2)] and [Mn(η-MeC5H4)(CO)2(NO)]PF6 forms [Mn(η-MeC5H4)(NO)(S2CNR2)]. The iodide ligands in I may be displaced by L, to give II, or by other ligands such as [CN]?, [NCS]?, H2O or pyridine whilst SnCl2 converts it to SnCl2I. The iodide counter-anion in II may be replaced by others to give [BPh4]?, [Co(CO)4]? or [NO3]? salts. However [CN]? acts differently and displaces (PhO)3P from [Co(η-C5H5){P(OPh)3}(S2CNMe)]I to give [Co(η-C5H5)(CN)(S2CNMe2)] which may be alkylated reversibly by MeI and irreversibly by MeSO3F to [Co(η-C5H5)(CNMe)(S2CNMe2)]+ salts. Conductivity measurements suggest that solutions of I in donor solvents are partially ionized with the formation of [Co(η-C5H5)(solvent)(S2CNR2)]+ I? species. The IR and 1H NMR spectra of the various complexes are reported. They are consistent with pseudo-octahedral “pianostool” molecular structures in which the bidentate dithiocarbamate ligands are coordinated to the metal atoms through both sulphur atoms.  相似文献   

15.
A novel iridium(I) complex bearing a chelate-coordinated pyridine-2-thiolate ligand [Ir(η2-SNC5H4)(PPh3)2] (2) was prepared by the reaction of iridium ethylene complex [IrCl(C2H4)(PPh3)2] (1) with lithium salt of pyridine-2-thiol (Li[SNC5H4]). On the treatment of iridium(I) complex 2 with chloroform, iridium(III) dichloro-complex [IrCl22-SNC5H4)(PPh3)2] (3) was formed. Reactions of complex 2 with methyldiphenylsilane, acetic acid, and p-tolylacetylene afforded iridium(III) hydride complexes [IrH(SiMePh2)(η2-SNC5H4)(PPh3)2] (4), [IrH(O2CCH3)(η2-SNC5H4)(PPh3)2] (5), and [IrH(CC(p-tolyl))(η2-SNC5H4)(PPh3)2] (6), respectively. Complex 2 catalyzed dimerization of terminal alkynes leading to enynes (7) with high E-selectivity via C-H bond activation.  相似文献   

16.
The effect of unilamellar vesicles of dipalmitoylphosphotidylcholine (DPPC), both below and above the phase transfer region, on the second-order rate constants for outer-sphere electron transfer between Fe2+ and the surfactant?Ccobalt(III) complexes, cis-[Co(en)2(C12H25NH2)2]3+ and cis-[Co(trien)(C12H25NH2)2]3+ (en?=?ethylenediamine, trien?=?triethylenetetramine, C12H25NH2?=?dodecylamine) was studied by UV?CVis absorption spectroscopy. Below the phase transition temperature of DPPC, the rate decreased with increasing concentration of DPPC, while above the phase transition temperature the rate increased with increasing concentration of DPPC. It is concluded that below the phase transition temperature, there is an accumulation of surfactant?Ccobalt(III) complexes at the interior of the vesicle membrane through hydrophobic effects, and above the phase transition temperature the surfactant?Ccobalt(III) complex is released from the interior to the exterior surface of the vesicle. Through isokinetic plots, we have established that the mechanism of the reaction does not alter during the phase transition of DPPC.  相似文献   

17.
Reaction of 2‐chloro‐1,3,2‐diazaarsolenes and ‐diazaphospholenes with Tl[Co(CO)4] gives instable complexes of type [Co(ER2)(CO)4] which decarbonylated to yield [Co(ER2)(CO)3]. Spectroscopic and X‐ray diffraction studies revealed that the tetracarbonyl complexes can be formulated as ion pair for E = P and as covalent metalla‐arsine for E = As, and the tricarbonyl complexes as carbene‐like species with a formal E=Co double bond. A similar reactivity towards Tl[Co(CO)4] was also inferred for 1,3,2‐diazastibolenes although the products were not isolable and their constitution remained uncertain. Evaluation of structural and computational data suggests that the weak and polarized Co–As bond in [Co(AsR2)(CO)4] can be characterized as an “inverse” M→L donor‐acceptor bond. The computational studies disclosed further η2(EN)‐coordination of the EN2C2 heterocycle as an alternative to the formation of a carbene‐like structure for [Co(ER2)(CO)3]. The η2‐complex is less stable for E = P but close in energy for E = As and more stable than the carbene‐like complex for E = Sb.  相似文献   

18.
Four homochiral coordination polymers incorporating two chiral reduced Schiff base ligands, namely, [Cu(L1)(H2O)]·H2O (1), [Zn2(L2)2] (2), [Co(L2)(H2O)] (3), and [Ni(L2)(H2O)] (4) (H2L1 = N-(4-carboxyl)benzyl-l-alanine, H2L2 = N-(4-carboxyl)benzyl-l-leucine) have been obtained by hydrothermal methods and characterized by physico-chemical and spectroscopic methods. X-ray crystallographic analysis reveals that complex 1 exhibits a chain structure with 1D channels. Complexes 24 all are 3D network structures with 1D channels in which the isobutyl group of the ligand points toward to the channel. Complex 2 displays strong photoluminescent emission in the purple region.  相似文献   

19.
A new layered carbide, [Zr0.72(3)Y0.28(3)]Al4C4, has been synthesized and characterized by X-ray powder diffraction, transmission electron microscopy and energy dispersive X-ray spectroscopy (EDX). The atom ratios [Zr:Y] were determined by EDX, and the initial structure model was derived by the direct methods, and further refined by Rietveld method. The crystal is trigonal (space group , Z=1) with lattice dimensions of a=0.333990(5) nm, c=1.09942(1) nm and V=0.106209(2) nm3. This compound shows an intergrowth structure with [Zr0.72Y0.28C2] thin slabs separated by Al4C3-type [Al4C4] layers. It is a new member with l=1 and m=1 of the homologous series, the general formula of which is (MC)l(T4C3)m (l=1, 2 and 3, m=1 and 2, M=Zr, Y and Hf, T=Al, Si and Ge).  相似文献   

20.
A new series of chiral NHC–rhodium complexes has been prepared from the reactions between [Rh(COD)Cl]2, NaOAc, KI and dibenzimidazolium salt 4a or monobenzimidazolium salts 4bd, which are derived from chiral 2,2′-diamino-6,6′-dimethyl-1,1′-biphenyl, 2,2′-diamino-1,1′-binaphthyl or 6,6′-dimethyl-2-amino-2′-hydroxy-1,1′-biphenyl. The steric and electronic effects of the ligand play an important role in the complex formation. For example, treatment of chiral monobenzimidazolium salt 4b (with a NMe2 group) with 0.5 equiv of [Rh(COD)Cl]2 in the presence of NaOAc and KI in CH3CN at reflux gives a chiral Rh(I) complex 5b, while chiral monobenzimidazolium salt 4d (with a MeO group) affords a racemic Rh(I) complex 5d. Under similar reaction conditions, treatment of dibenzimidazolium salt 4a with 0.5 equiv of [Rh(COD)Cl]2 in the presence of NaOAc and KI gives a racemic Rh(III) complex 5a, while the dibenzimidazolium salt [C20H12(C7H5N2Me)2]I2 derived from chiral 2,2′-diamino-1,1′-binaphthyl affords a chiral Rh(III) complex [C20H12(C7H4N2Me)2]RhI2(OAc). All compounds have been characterized by various spectroscopic techniques, and elemental analyses. The solid-state structures of the rhodium complexes have been further confirmed by X-ray diffraction analyses.  相似文献   

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