Noise Effects on Oscillator Network of Transcription Regulators

Based on the model describing the regulation of the PRM operator region of λ phage proposed by Jeff Hastyet al., we study the noise effects on the oscillator network. We find that the additive noise cannot change the period andthe amplitude of the relaxation oscillator, but in the multiplicative case, the period of the relaxation oscillator increasesto a constant value with the increase of the strength of noise, and the amplitude of the relaxation oscillator also showsincreases with the increase of the strength of noise. This novel results suggest that an external multiplicative noise sourcecould be used to control gene expression.     

Effect of Correlated Dichotomous Noises on Stochastic Resonance in a Linear System

A linear system driven by correlated asymmetric dichotomous noises and periodic signal was investigated in the overdamped case. The exact expressions of output signal amplitude and signal-to-noise ratio (SNR) of the system were derived. By means of numerical calculations, we found that: (i) At some fixed multiplicative noise intensities, the output signal amplitude with frequency exhibits the structure of a weak peak, even no peak as the dichotomous noise is asymmetric; (ii) In the case of asymmetric dichotomous noise, the signal frequency can cause non-monotonous behavior of the output signal amplitude with respect to multiplicative noise intensity; (iii) The curve of SNR with frequency has a weak peak and a trough in the case of symmetric dichotomous noise, but no peak with asymmetric; (iv) Whether the multiplicative noise is symmetric or asymmetric, the noise can enhance response of the system; (v) The SNR increases with the correlation strength between the two noises decreasing. In addition, the plane of multiplicative noise intensity versus noise symmetric parameter was plotted.     

Tests of numerical simulation algorithms for the Kubo oscillator

Numerical simulation algorithms for multiplicative noise (white or colored) are tested for accuracy against closed-form expressions for the Kubo oscillator. Direct white noise simulations lead to spurious decay of the modulus of the oscillator amplitude. A straightforward colored noise algorithm greatly reduces this decay and also provides highly accurate results in the white noise limit.     

Random oscillator with general Gaussian noise

We study the long time behaviour of a nonlinear oscillator subject to a random multiplicative noise with a spectral density (or power-spectrum) that decays as a power law at high frequencies. When the dissipation is negligible, physical observables, such as the amplitude, the velocity and the energy of the oscillator grow as power-laws with time. We calculate the associated scaling exponents and we show that their values depend on the asymptotic behaviour of the external potential and on the high frequencies of the noise. Our results are generalized to include dissipative effects and additive noise.     

乘性二次噪声驱动的线性过阻尼振子的随机共振

针对乘性二次噪声和加性周期调制噪声联合驱动的线性过阻尼振子, 利用随机平均法推导了系统响应的一阶、 二阶稳态矩以及稳态响应振幅和方差的解析表达式. 理论分析和仿真实验均表明这类系统具有比传统的由线性噪声驱动的线性系统更丰富的动力学特性; 当二次噪声的系数满足一定条件时, 系统稳态响应的振幅及方差均存在广义随机共振现象.     

周期外力对频率涨落的过阻尼谐振子所作的功和能量随机共振

研究了周期外力对频率涨落的过阻尼谐振子系统作功的特点. 结果揭示了瞬时功率随时间的周期变化出现不对称性. 研究结果还揭示周期外力一个周期对系统所做的功随乘法噪声强度的变化出现非单调行为, 系统是否出现能量随机共振与抑制并存, 由乘法噪声与加法噪声之间互关联的符号决定. 关键词： 过阻尼谐振子 频率涨落 周期外力作功 能量随机共振与抑制     

Dynamics of Gompertzian tumour growth under environmental fluctuations

We investigate the effect of correlated additive and multiplicative Gaussian white noise on the Gompertzian growth of tumours. Our results are obtained by solving numerically the time-dependent Fokker-Planck equation (FPE) associated with the stochastic dynamics. In our numerical approach we have adopted B-spline functions as a truncated basis to expand the approximated eigenfunctions. The eigenfunctions and eigenvalues obtained using this method are used to derive approximate solutions of the dynamics under study. We perform simulations to analyze various aspects, of the probability distribution, of the tumour cell populations in the transient- and steady-state regimes. More precisely, we are concerned mainly with the behaviour of the relaxation time (τ) to the steady-state distribution as a function of (i) of the correlation strength (λ) between the additive noise and the multiplicative noise and (ii) as a function of the multiplicative noise intensity (D) and additive noise intensity (α). It is observed that both the correlation strength and the intensities of additive and multiplicative noise, affect the relaxation time.     

Mode competition Effects of a Two Mode Laser with Multiplicative Colored Noise

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New Type of Brownian Motion

We consider an oscillator with a random mass for which the particles of the surrounding medium adhere to the oscillator for some random time after the collision (Brownian motion with adhesion for a harmonically bound particle). This is another form of a stochastic oscillator, different from oscillator usually studied that is subject to a random force or having random frequency or random damping. Calculation of the first two stationary moments shows that for white multiplicative noise of week strength the second moment coincides with that of usual Brownian motion, but for symmetric dichotomous noise, the second moment may appear the same type of the “energetic” instability, which exists for white noise random frequency or damping coefficient.     

乘性色噪声激励下三稳态van der Pol-Duffing振子随机P-分岔

研究了乘性色噪声作用下三稳态van der Pol-Duffing振子的随机P-分岔问题. 首先应用随机平均法得到系统振动幅值稳态概率密度函数的表达式, 进而应用奇异性理论, 得到刻画随机P-分岔发生的临界参数条件的转迁集以及系统存在的典型稳态概率密度曲线, 并通过Monte-Carlo数值模拟进行了验证. 以此为基础讨论了噪声强度、相关时间、系统线性阻尼系数对随机P-分岔和系统稳态响应行为的影响.     

Spectral purity and phase coherence of narrow-band noise in NbSe3

An unusually simple narrow band noise spectrum with a single fundamental and seven harmonics due to depinned charge density wave motion in NbSe₃ is reported. The simplicity of the spectrum is attributed to a very uniform current distribution associated with a short, thin sample of high perfection. The distribution of harmonics is near to that of the sawtooth waveform generated by a relaxation oscillator. As indicated by the amplitude ratio of the fundamental to the first harmonic, this distribution has only a moderate variation over three orders of magnitude in frequency. An electrical relaxation oscillator analog which reproduces most of the properties of CDW motion in NbSe₃ is discussed. A search for phase memory of the narrow band noise in NbSe₃ showed it to be less than one period.     

Mean-square displacement of a stochastic oscillator: Linear vs quadratic noise

Using the Langevin equations, we calculated the stationary second-order moment (mean-square displacement) of a stochastic harmonic oscillator subject to an additive random force (Brownian motion in a parabolic potential) and to different types of multiplicative noise (random frequency or random damping or random mass). The latter case describes Brownian motion with adhesion, where the particles of the surrounding medium may adhere to the oscillator for some random time after the collision. Since the mass of the Brownian particle is positive, one has to use quadratic (positive) noise. For all types of multiplicative noise considered, replacing linear noise by quadratic noise leads to an increase in stability.     

Noise-induced mixed-mode oscillations in a relaxation oscillator near the onset of a limit cycle

A detailed asymptotic study of the effect of small Gaussian white noise on a relaxation oscillator undergoing a supercritical Hopf bifurcation is presented. The analysis reveals an intricate stochastic bifurcation leading to several kinds of noise-driven mixed-mode oscillations at different levels of amplitude of the noise. In the limit of strong time-scale separation, five different scaling regimes for the noise amplitude are identified. As the noise amplitude is decreased, the dynamics of the system goes from the limit cycle due to self-induced stochastic resonance to the coherence resonance limit cycle, then to bursting relaxation oscillations, followed by rare clusters of several relaxation cycles (spikes), and finally to small-amplitude oscillations (or stable fixed point) with sporadic single spikes. These scenarios are corroborated by numerical simulations.     

Analytic approximations of statistical quantities and response of noisy oscillators

Nonlinear oscillators have been utilized in many contexts because they encompass a large class of phenomena. For a reduced phase oscillator model with weak noise forcing that is necessarily multiplicative, we provide analytic formulas for the stationary statistical quantities of the random period. This is an important quantity which we term ‘response’ (i.e., the spike times, instantaneous frequency in neuroscience, the cycle time in chemical reactions, etc.) that is often analytically intractable in noisy oscillator systems. The analytic formulas are accurate in the weak noise limit so that one does not have to numerically solve a time-varying Fokker-Planck equation. The steady-state and dynamic responses are also analyzed with deterministic forcing. A second order analytic formula is derived for the steady-state response, whereas the dynamic response with time-varying forcing is more complicated. We focus on the specific case where the forcing is sinusoidal and accurately capture the frequency response with an analytic approximation that is obtained with a rescaling of the equation. By utilizing various techniques in the weak noise regime, this work leads to a better understanding of how the random period of nonlinear oscillators are affected by multiplicative noise and external forcing. Comparisons of the asymptotic formulas with a full oscillator system confirm the qualitative accurateness of the theory.     

Multiplicative-noise-induced amplification of weak signals in a system with on—off intermittency

A model of an overdamped Kramers oscillator perturbed by strong multiplicative Gaussian noise and a weak periodic signal is studied theoretically and experimentally. It is shown that under certain conditions such a system demonstrates on-off intermittency and sensitivity to very weak periodic signals, making possible many-fold (experimentally, by two orders of magnitude) amplification of the signal amplitude.     

双色噪声驱动光学双稳系统的弛豫时间研究

研究乘性及加性噪声的自关联时间τ₁和τ₂,交叉关联时间τ对光学双稳系统的弛豫时间的影响.弛豫时间T由Mei等所采用的方法得到. 经数值计算, 结果表明: 两噪声间交叉关联时间τ及乘性噪声的自关联时间τ₁延缓系统涨落的消退(T随τ及τ₁的增大而增大);T随加性噪声的自关联时间τ 关键词： 关联噪声 弛豫时间 光学双稳系统     

关联噪声驱动的非对称双稳系统的随机共振

运用统一色噪声近似理论和两态模型理论,研究了周期矩形信号和关联的乘性色噪声和加性白噪声驱动的非对称双稳系统的随机共振现象,得到了适合信号任意幅值的信噪比表达式.信噪比是乘性噪声强度、加性噪声强度、乘性噪声自关联时间、噪声耦合强度的非单调函数,所以该双稳系统中出现了随机共振.同时,调节加性噪声强度比调节乘性噪声强度更容易产生随机共振.势阱静态非对称性和噪声之间的耦合强度对信噪比的影响是不同的. 关键词： 非对称双稳系统 随机共振 信噪比 周期矩形信号     

Hypersensitivity to small signals in a stochastic system with multiplicative colored noise

Recently we discovered the phenomenon of hypersensitivity to small time-dependent signals in a simple stochastic system, the Kramers oscillator with multiplicative white noise. In the present work we study, theoretically and experimentally with analog simulations, an influence of noise correlation time on hypersensitivity in a nonlinear oscillator with piecewise-linear current-voltage characteristic and multiplicative colored dichotomous noise. We found that the region of hypersensitive behavior is defined by universal scaling index, whereas the specifics of a particular system reveals itself only in the dependence of the above index on system parameters. The dependence of gain factor on noise correlation time is of bell-shaped (resonant) type. Received 27 April 2000 and Received in final form 2 November 2000     

关联高斯与非高斯噪声激励的FHN神经元系统的稳态分析

本文主要研究了关联乘性非高斯噪声和加性高斯白噪声共同激励的FHN(Fitz Hugh-Nagumo)神经元系统.利用路径积分法和统一色噪声近似,推导出该系统的定态概率密度函数表达式.通过研究发现,乘性噪声强度D、加性噪声强度Q、噪声自关联时间τ以及互关联系数λ均可以诱导系统产生非平衡相变现象,而非高斯参数q却不可以诱导系统产生非平衡相变现象.此外,我们还发现参数D和λ的增大有利于神经元系统从激发态向静息态转换,Q和τ的增大有利于神经元系统从静息态向激发态转换,q的增大会使得神经元系统停留在静息态的概率增加.