蓝靛果的化学成分及其提取分离研究进展

蓝靛果（Lonicera cearulea L.）是一种天然野生的可食用浆果,具有清除自由基、抑制炎症通路相关蛋白的磷酸化、抑制癌细胞增殖等生理活性,其抗氧化、调节血脂、抗肿瘤和防辐射等保健功效可应用于调节肠道菌群结构、抗癌、抗肥胖和保护视力等多个功能食品领域,且蓝靛果抗寒能力强,易于种植,具有极高的市场开发价值。研究总结整理了蓝靛果中活性化学成分（原花青素类、花青素类、花色苷类、黄酮类、有机酸类、多糖类及其它类化合物）的化学信息,归纳整理了不同类型化学成分的提取分离技术（溶剂提取法、酶解法、微波辅助提取法等）,以期为蓝靛果深入研发及深加工产品的开发提供依据。     

Accumulation Pattern of Flavonoids during Fruit Development of Lonicera maackii Determined by Metabolomics

Lonicera maackii (Caprifoliaceae) is a large, upright shrub with fruits that contain many bioactive compounds. Flavonoids are common active substances in L. maackii. However, there is a dearth of information about the accumulation of these flavonoids and their possible medicinal value. We used targeted metabolomics analysis based on ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to analyze five developmental stages of L. maackii fruit. A total of 438 metabolites were identified in the five developmental stages, including 81 flavonoids and derivatives. The 81 flavonoids included 25 flavones and derivatives, 35 flavonols and derivatives, two isoflavones, three cyanidins and derivatives, eight procyanidins, and eight flavanones. In addition, we outlined the putative flavonoid biosynthesis pathway and screened their upstream metabolites. More importantly, we analyzed the accumulation patterns of several typical flavones and flavonols. The results reported here improved our understanding of the dynamic changes in flavonoids during fruit development and contributed to making full use of the medicinal value of L. maackii fruit.     

湘西金银花挥发油化学成分研究

采用ＧＣ／ＭＳ／ＤＳ联用仪对湘西金角花挥发油中的化学成分进行了研究。并鉴定出４０种组分。其主要成分为：芳樟醇、环氧芳樟醇、α－萜品醇、顺－３－已 烯醇、顺芷酸－３、己烯酯、香叶醇、氧化芳樟醇、法尼醇、顺－苯酮、法尼烯、大根香叶烯、橙花醇等。其中芳樟醇含量最高,约占精油总量的２０％。     

Chemical Constituents of Phyllanthus reticulatus

A new purine derivative, 3‐(3‐methylbut‐2‐en‐1‐yl)isoguanine ( 1 ), and a new cleistanthane‐type diterpenoid glucoside, 19‐hydroxyspruceanol 19‐O‐β‐D ‐glucopyranoside ( 2 ), together with eight known compounds were isolated from the whole plant of Phyllanthus reticulatus. The structures were elucidated by chemical and spectroscopic methods.     

Chemical Constituents of Tripterygium wilfordii

The two new triterpenoids, (5β,8α,9β,10α,13α,14β)‐5,9,13‐trimethyl‐4‐oxo‐3,24,25,26‐tetranor‐2,3‐secooleanane‐2,29‐dioic acid (=4‐oxo‐D:A‐friedo‐3‐nor‐2,3‐secooleanane‐2,29‐dioic acid; 1 ) and (2α,3β,4β,5β,8α,9tlsb=‐2%>β,10α,13α,14β,24R)‐3,24‐epoxy‐24‐ethoxy‐2‐hydroxy‐5,9,13‐trimethyl‐24,25,26‐trinoroleanan‐29‐oic acid (=3β,24‐ epoxy‐24α‐ethoxy‐2α‐hydroxy‐D:A‐friedooleanan‐29‐oic acid; 2 ) (absolute configurations tentative), together with a novel bi‐2H‐benzopyran, namely (rel‐(3R,3′S,4R,4′S)‐3,3′,4,4′‐tetrahydro‐6,6′‐dimethoxy[3,3′‐bi‐2H‐benzopyran]‐4,4′‐diol ( 3 ), were isolated from Tripterygium wilfordii Hook . f. Their structures were established by chemical and spectroscopic studies and by X‐ray crystallography.     

Chemical Constituents of Euphorbia glomerulans

Chemistry of Natural Compounds -     

Chemical Constituents of Artemisia frigida

Chemistry of Natural Compounds -