共查询到20条相似文献,搜索用时 31 毫秒
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2—芳酰氨基—5—苄基—1,3,4—噻二唑的合成及其与苯甲醛反应的研究 总被引:1,自引:0,他引:1
1-酰基-4-芳基氨基硫脲类在酸催化下环化为具有广泛生物活性的2-芳氨基-5-芳基-1,3,4-噻二唑类的反应报道甚多,但1,4-二酰基氨基硫脲在相同条件下环化为类似结构衍生物的反应报道很少。为探索其规律,本文研究了1-苯乙酰基-4-芳酰氨基硫脲1_(a-m)在冰醋酸存在下的环化反应,制得2-芳酰氨基-5-苄基-1,3,4-噻二唑2_(a-m)。参考文献还探索了2_(a-m)在EtONa/EtOH体系中与苯甲醛的反应。得到预期产物2-芳酰氨基-5-(1′-苯基-2′-羟基苯乙基)-1,3,4-噻二唑3_(a-m),经元素分析、IR、~1H NMR及MS确认了产物结构。 相似文献
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Yan B Wang G Sun J Li X Zheng Y Ai H Lv H Wu X Xu J 《Biomedical chromatography : BMC》2007,21(9):912-924
5-n-Butyl-4-{4-[2-(1H-tetrazole-5-yl)-1H-pyrrol-1-yl]phenylmethyl}-2,4-dihydro-2-(2,6-dichloridephenyl)-3H-1,2,4-triazol-3-one (1b), a new non-peptide angiotensin type 1 receptor antagonist, has been observed to play a positive role in the treatment of hypertension in preclinical tests. Rats were dosed with the drug, and the major metabolites in the bile were separated by gradient elution high-performance liquid chromatography. HPLC-diode array detection-mass spectrometry, HPLC-electrospray ionization MS/MS methods in negative ion mode and collision-induced dissociation were used to elucidate the structures of the major metabolites of 1b. One dihydroxylated 1b (M1), two monohydoxylated 1b (M2, M3) and one 1b monoglucuronide (M5) were found in male rat bile; however, three monohydoxylated 1b (M2, M3, M4) and one 1b monoglucuronide (M5) were found in female rat bile. These metabolites greatly differ in amount between male and female rat bile. 相似文献
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正如前文报道,l,3,4—噻二唑类杂环之所以有除草,植物生长调节,驱虫以及消炎等多种生物活性,无疑起因于噻唑母核。尽管母核上取代基不起主导作用,但它作为辅助基,在改善分子溶解性以及药效方面所产生的影响是不能忽略的。因而深入研究各种生物活性基团导入噻二唑环母核以制得多结构单元聚集于同一分子中的噻二唑新衍生物,对于开发多功能新药具有一定的理论意义和实际价值。 相似文献
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Askerov R. K. Magerramov A. M. Osmanov V. K. Baranov E. V. Borisova G. N. Samsonova A. D. Borisov A. V. 《Russian Journal of Coordination Chemistry》2019,45(2):112-118
Russian Journal of Coordination Chemistry - The molecular and crystal structures of 1-(2-methoxyphenyl)-1,4-dihydro-5H-tetrazole-5-thione (L) and its complex with cadmium(II) (II) are studied by... 相似文献
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The lowest triplet energy levels of the six ligands(T) were determined to be 22989 cm-1[1,3-bis-(1'-phenyl-3'-methyl-5'-pyrazolon-4')-1,3-propanedione,BPMPTD],23148 cm-1[1,4-bis-(1'-phenyl-3'-methyl-5'-pyrazolon-4')-1,4-butanedione,BPMPBD],23419 cm-1[1,5-bis-(1'-phenyl-3'-methyl-5'-pyrazolon-4')-1,5-pentane-dione,BPMPPD],23310 cm-1[1,6-bis-(1'-phenyl-3'-methyl-5'-pyrazolon-4')-1,6-hexanedione,BPMPHD],21978 cm-1[1,9-bis-(1'-phenyl-3'-methyl-5'-pyrazolon-4')-l,9-nonanedione,BPMPND] and 21930 cm-1[1,10-bis-(1'-phenyl-3'-methyl-5'-pyrazoion-4')-1,10-decanedione,BPMPDD],respectively.It was explained satisfactorily that the six ligands are more efficient for sensitizing the luminescence of Tb3+ than that of Eu3+ at room temperature,and the order of the luminescent intensities for the Tb3+ complexes is explained by the relative energy gap between T and 5DJ of Tb3+ or Eu3+.As a conclusion,when 2700 cm-1<△E(T-5D4)<3000 cm-1,the luminescent intensity of the Tb3+ complex is the strongest.This means that the lowest triplet energy level of the ligand is a chief factor to dominate RE3+luminescence. 相似文献
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Jun Min HUANG* Hui CHEN Ru Yu CHEN Institute of Elemento-Organic Chemistry National Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 《中国化学快报》2002,(2)
Organophosphorus compounds are ubiquitous in nature and they have broad applications in the fields of agriculture and medicine1-4. There has been a considerably growing interest in heterocyclic compounds due to their pharmaceutical importance and extensive application in organic synthesis, and the application of heterocycles is suggested to enhance the biological activity and/or offer other diverse properties5-7. In the previous work8, we have reported that 11-ethoxycarbonylmethyl-6-oxo-3, 4… 相似文献
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吡喃酮是许多天然产物的结构单元,我们曾由4-异丁酰基庚二酸在过量醋酸酐及乙酰氯存在下回流得到7-氧代-8,8-二甲基-△~9-六氢香豆素.本文由二氰乙基-β-二酮进行酮解水解反应得到4-酰基庚二酸1_(a-c)。 在过量醋酸酐、乙酰氯存在下由1_a、1_c为底物进行反应没有得到双环的香豆素衍生物.其产物和单纯以乙酐为缩合剂时的产物2_a、2_c相同,产率分别为68%、63%。2_c可在硫酸铁催化 相似文献
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Xin Bo ZHOU Cui Fang LIN Song LI 《中国化学快报》2005,16(10):1301-1304
The synthesis of (S)-2-(3-arylacrylamido)-3-{4-[2-(5-methyl-2-phenyloxazol-4-yl)etho- xy]phenyl}propanoic acids is described. Their structures were confirmed by ^1H-NMR. 相似文献
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3-(3-Aryl-4-formyl-1-pyrazolyl)propionic acids are converted by Knoevenagel condensation under conditions of microwave activation
into 3-[3-aryl-1-(2-ethoxycarbonyl)-4-pyrazolyl]acrylic acids. Reduction of the latter with hydrazine hydrate in the presence
of Raney nickel gives 3-[3-aryl-1-(2-ethoxycarbonyl)-4-pyrazolyl]propionic acids.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 686–690, May, 2006. 相似文献
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S. G. Krivokolysko V. D. Dyachenko V. N. Nesterov V. P. Litvinov 《Chemistry of Heterocyclic Compounds》2001,37(3):315-319
The stereoselective synthesis of 3-allyl-4-(4-bromophenyl)-3-cyano-6-oxopiperidine-2-thione has been carried out by refluxing N-methylmorpholinium 5-[1-(4-bromophenyl)-2-cyano-2-thiocarbamoylethyl]-2,2-dimethyl-1,3-dioxa-6-oxo-4-cyclohexen-4-olate with allyl bromide in ethanol. The structure of the product was confirmed by X-ray investigation. 相似文献
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研究了3-(2'-苯基-1', 2', 3'-连三唑-4'-基)-4-氨基-5-巯基-1, 2, 4-三唑(1)与取代苯甲酸和脂肪酸(2a-r)在POCl3催化下的反应, 共合成得到18个新的3-(2'-苯基-1', 2', 3'-连三唑-4'-基)-6-烷基/芳基-均三唑并[3, 4-b]-1, 3, 4-噻二唑(3a-r), 经元素分析,IR, 1H NMR和MS进行了结构确证。 相似文献
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2, 5-二取代基-1, 3, 4-恶二唑及恶二唑啉类化合物的合成 总被引:40,自引:0,他引:40
2-苯基-1,2,3-连三唑-4-甲酰肼(1)与芳酸在POCl~3催化下得到6种新的2-芳基-5-(2'-苯基-1',2',3'-连三唑-4'-基)-1,3,4-恶二唑(2)。1与羰基化合物缩合得到相应的酰腙(3),在Ac~2O作用下环化成2-取代基-3-乙酰基-5-(2'-苯基-1',2',3'-连三唑-4'-基)-1,3,4-恶二唑啉(4)。化合物的结构经元素分析,IR,^1HNMR和MS确证。 相似文献
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3-Aryl-4-(5-aryl-Δ2-1,2,4-oxadiazolin-3-yl)sydnones (5) were synthesized in high yields by the reaction of 3-arylsydnone-4-carboxamide oximes (prepared from the corresponding 3-arylsydnone-4-carbonitriles) with aromatic aldehydes in the presence of acid catalysts. No reaction occurred when aliphatic aldehydes were used. The oxadiazolin-3-ylsydnones (5) were easily converted into the corresponding 3-aryl-4-(5-aryl-1,2,4-oxadiazol-3-yl)sydnones by N-bromosuccinimide oxidation. The 3-arylsydnone-4-carbonitrile oxides were synthesized in good yields by N-bromosuccinimide oxidation of the corresponding 3-arylsydnone-4-carboxaldehyde oximes. 相似文献
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IntroductionThe investigation of organic photochromic materials has increased considerably in recentyears because of their potential commercial application in several areas,such as high-densityoptical storage media,optical switching,etc.[1 ,2 ] .Though numerous organic photochromicmolecular systems or photoactive devices have been explored so far,those systems classifiedaccording to the photochromic structural units mainly belong to a small number of families:fulgides,spiropyrans and spiroxazi… 相似文献
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New pyrazolino- and pyrrolidino[60]fullerenes with transition-metal chelating pyridine substitutents: synthesis and complexation to Ru(II) 总被引:1,自引:0,他引:1
Three pyridine-substituted fullerene adducts, bis(2,2'-bipyridine)(2'-phenyl-5'-(2-pyridinyl)-2'H-[5,6]fullereno(C(60)-I(h))[1,9]pyrazole)ruthenium-bis(hexafluorophosphate) (1), bis(2,2'-bipyridine)(2'-phenyl-5'-(4-(4'-methyl-2,2'-bipyridinyl))-2'H-[5,6]fullereno(C(60)-I(h))[1,9]pyrazole)ruthenium-bis(hexafluorophosphate) (2), and bis(2,2'-bipyridine)(1',5'-dihydro-3'-methyl-2'-(4-(4'-methyl-2,2'-bipyridinyl))-2'H-[5,6]fullereno(C(60)-I(h))[1,9]pyrrole)ruthenium-bis(hexafluorophosphate) (3), have been prepared. The common features for these complexes are the short bridges between the fullerene and the pyridine moieties. [structure: see text] 相似文献