Resolution of gram quantities of a subtly chiral polyoxometalate (POM; the chirality originates from substitution of one metal in the nanosized framework) is possible by reaction with small peptides. Functionalizable acyl polyoxotungstate (TBA)6[α1‐P2W17O61{SnCH2CH2C(?O)}] (see picture) can be resolved by kinetic resolution. This approach paves the way for applications of chiral POMs ranging from asymmetric catalysis to their bioactivity.
In this study, direct separation of ketoprofen enantiomers was performed on a Chirobiotic T column.
Methods
The effects of the type and amount of the organic modifier, buffer concentration, pH value, temperature and flow rate on retention and selectivity were investigated. Experiments were carried out in the temperature range of 20–40 °C to study the effects of temperature. Thermodynamic parameters were calculated from plots of ln k or ln α versus 1/T. Molecular dynamics simulation was done to investigate interactions between ketoprofen enantiomers and the chiral selector—teicoplanin.
Results
It was observed that pH and flow rate had a large influence on resolution. Baseline separation of ketoprofen enantiomers could be achieved with low amounts of methanol, high temperature and high buffer concentrations.
Conclusions
Results from a thermodynamic study and molecular dynamics simulation show that steric hindrance effect, π–π complexation, hydrogen bonding and electrostatic forces are the main driving forces which cause chiral recognition of ketoprofen enantiomers.
In this study, direct separation of ketoprofen enantiomers was performed on a Chirobiotic T column.
Methods
The effects of the type and amount of the organic modifier, buffer concentration, pH value, temperature and flow rate on retention and selectivity were investigated. Experiments were carried out in the temperature range of 20?C40?°C to study the effects of temperature. Thermodynamic parameters were calculated from plots of ln k or ln ?? versus 1/T. Molecular dynamics simulation was done to investigate interactions between ketoprofen enantiomers and the chiral selector??teicoplanin.
Results
It was observed that pH and flow rate had a large influence on resolution. Baseline separation of ketoprofen enantiomers could be achieved with low amounts of methanol, high temperature and high buffer concentrations.
Conclusions
Results from a thermodynamic study and molecular dynamics simulation show that steric hindrance effect, ?ШC?? complexation, hydrogen bonding and electrostatic forces are the main driving forces which cause chiral recognition of ketoprofen enantiomers. 相似文献
In recent years,chiral discrete supramolecular coordination complexes have attracted increasing interest as simple enzyme mimetics owing to their aesthetic arch... 相似文献
Non-precious transition metal oxide nanomaterials offer numerous opportunities for various cost-effective electrochemical applications. This review article features the design and advancement of such nanomaterials with unique features applied for the fabrication of electrochemical devices. Also, it discusses various new syntheses of transition metal oxide nanoparticles (TMO NPs) via multiple chemicophysical and biological procedures. Further, the novel appliances of the TMO NPs with varying sizes and morphologies are appraised. The advantages and challenges of a number of investigations on the TMO NPs towards electrochemical applications are addressed with their standpoint of cost-effectiveness, applicability, and the efficiency of the introduced nanostructures for the industrial applications. 相似文献
