共查询到20条相似文献,搜索用时 31 毫秒
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Two new guaianolides, namely, 3beta,8alpha-dihydroxy-13-methoxyl-4(14),10(15)-dien-(1alphaH,5alphaH,6beta H,11betaH)-12,6-olide (1) and 3beta,8alpha-dihydroxy-13-methoxyl-4(14),10(15)-dien-(1alphaH,5alphaH,6beta H,11alphaH)-12,6-olide (2), together with six known guaianolides, 8-hydroxyzaluzanin C, austricin, chlorojanerin, cynaropicrin, chlorohyssopifolin E and chlorohyssopifolin A were isolated from the aerial parts of Saussurea alata. The structures were established mainly based on spectral analysis, especially 2D NMR techniques. 相似文献
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Hong Zhu MA Bo WANG* College of Chemistry materials science ShaanXi Normal University Xian 《中国化学快报》2003,14(11)
During the past decades enormous progress was made in asymmetric catalytic synthesis, an well-known example is BINAP1, the chiral hydrogenation synthesis of S-(+)-naproxen catalyzed by BINAP-Ru dicarboxylate complexes provides excellent enantioselectivity (up to 99% ee) and good chemical yield (92%), however the pressures is relatively high (135-150 atm) and the (S)-BINAP-Ru(III) complex is very expensive. This problem may present a practical limitation. In recent years new methodolo… 相似文献
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Yun Mei BI Xu Bin BI Qian Rong ZHAO Fang A Ye Gao CHEN 《中国化学快报》2006,17(3):344-346
Cephalosporium sp. AL031 is a fungus isolated from Sinarundinaria nitida grown in the Ailao Mountain, Yunnan, China. It produces, in cultures, antibacterial and fungicidal secondary metabolites, according to the antimicrobial activity test1. In previous p… 相似文献
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萘普生(S)-(+)-2-(6-甲氧基-2-萘基)丙酸(1)是一种新型非甾体抗菌消炎药物,临床应用十分广泛,疗效显著[1]。其分子结构中有一个不对称碳原子,S体比R体的药理作用要强28倍[3]。 相似文献
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WANG Zhi-Cai ZHENG Qi-Huang GAO BiDepartment of Chemistry Zhongshan University Guangzhou Guangdon ChinaFAN Shi-YanInstrumentation Analysis Research Centre Zhongshan University Guangzhou Guangdon China 《中国化学》1994,12(4):372-377
Two key intermediates of cembranolides- (2E,6E,10E)-3,7,11,15-tetramethyl-9-phenylsulfonyl-2,6,10,14-tetraen-1-hexadecanol (1) and (2E,6E,10E,14E)-2,6,10,14-tetramethyl-8-phenylsulfonyl-2,6,10,14-tetraen-1,16-hexadecanediol (2) were synthesized starting from geraniol and linalool and some improved synthetic methods were used. 相似文献
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Dong Min Su Jing Qu You Cai Hu Shi Shan Yu Wen Zhao Tang Yun Bao Liu Shuang Gang Ma De Quan Yu 《中国化学快报》2008,19(7):845-848
A new ionone glycoside (6R,9R)-blumenyl α-L-rhamnopyranosyl-(1 → 6)-β-D-gluco-pyranoside (1), together with a new natural product 2-methoxyl-4-trans-pmpenyl-phenol α-L-rhamnopyranosyl-(1 → 6)-β-D-glucopyranoside (2), was isolated from the leaves ofNeoalsomitra integrifoliola. Their structures were elucidated by chemical and spectral analysis. Compound 1 showed weak anti-inflammatory and low-level antioxidant activities. 相似文献
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Ravikanth V Lakshmi Niranjan Reddy V Vijender Reddy A Ravinder K Prabhakar Rao T Siva Ram T Anand Kumar K Prakesh Vamanarao D Venkateswarlu Y 《Chemical & pharmaceutical bulletin》2003,51(4):431-434
The latex of Euphorbia nivulia afforded three new ingol diterpenes, 3-acetyl-8-methoxyl-7-angolyl-12-hydroxylingol (7), 3,12-diacetyl-7-hydroxy-8-methoxylingol (8), and 3,12-diacetyl-7-angolyl-8-hydroxylingol (9) along with five known ingol diterpenes 2-6 and a known triterpene cyclonivulinol (1). Their structures were established by means of spectroscopic analysis. Diterpenes 2-9 were evaluated for their cytotoxic activity. 相似文献
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Two novel lavandulyl flavonoids, (2S)-7-methoxyl-4",5"-dihydroxynorkurarinone (1) and (2S)-6"-hydroxynorkurarinone-7-O-beta-D-galactoside (2), were isolated from the rhizome of Sophora flavescens. Their structures were elucidated by spectral methods, including 2D NMR spectroscopy. Both compounds showed cytotoxic activity against Hela cells, with 2 being more active than 1. 相似文献
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Hong Zhu MA Bo WANG* Qi Zhen SHI Department of Chemistry Northwest University ShaanXi Key Laboratory of Physico-Inorganic Chemistry Xi抋n 《中国化学快报》2002,13(6)
a-Arylpropionic acids are an important class of non-steroidal anti-inflammatory agents1,2. The therapeutic efficacy of this class of drugs is well demonstrated by the introduction and extensive use of more than a dozen compounds exemplified by ibuprofen, naproxen, ketoprofen and flurbiprofen etc. However, in recent years the use of enantiomerical pure drugs in chemotherapy is becoming almost mandatory for enhancing specificity of drug action and reducing the toxicity. This awareness led to … 相似文献
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Qinge Ma Yongming Guo Baomin Luo Wenmin Liu Rongrui Wei Chunxia Yang 《Natural product research》2016,30(16):1824-1829
Two new phenylethanoid glycosides, namely β-D-glucopyranoside, 1″-O-(7S)-7-(3-methoxyl-4-hydroxyphenyl)-7-methoxyethyl-3″-α-L-rhamnopyranosyl-4″-[(8E)-7-(3-methoxyl-4-hydroxyphenyl)-8-propenoate] (1) and β-D-glucopyranoside, 1″-O-(7S)-7-(3-methoxyl-4-hydroxyphenyl)-7-methoxyethyl-3″-α-L-rhamnopyranosyl-4″-[(8E)-7-(4-hydroxyphenyl)-8-propenoate] (2), together with six phenylethanoid glycosides were isolated from Cirsium setosum. Their structures were elucidated by their spectroscopic data and references. Compounds 2, 4, 5, 7 and 8 (10 μM) exhibited moderate hepatoprotective activities. Compounds (3–8) were obtained from this plant for the first time. 相似文献
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油菜甾醇内酯(brassinolide)(1)是一种高效植物生长激素,一些实验室曾成功地进行了合成(图1)。这些合成路线不少是以20-S-22-甾醛为关键中间体,再分步接上侧链的,而C_(20)-S-22-甾醛大都由豆甾醇为原料制得。考虑到豆甾醇来源困难,我们采用国内资源丰富、价格低廉的薯蓣皂甙元为起始原料,立体选择性地合成了C_(20)-S-22-甾醛化合物7(见图2),对1及其 相似文献
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以四-(4-甲氧基-3-磺酸基苯)卟啉(T(4-Mop)PS4)为探针,通过T(4-Mop)PS4与牛血清白蛋白(BSA)的相互作用,建立了测定BSA的电化学分析方法。T(4-Mop)PS4的峰电流变化(ΔIp)与BSA在2.0×10-6~1.0×10-5mol.L-1范围内呈良好的线性关系,检出限为1.2×10-6mol.L-1;对5.0×10-6mol.L-1BSA平行测定8次,其相对标准偏差为2.0%,回收率为95%~104%。组氨酸、缬氨酸、苯丙氨酸、丝氨酸、异白氨酸、谷氨酰胺、苏氨酸等氨基酸对BSA的测定不产生干扰。采用紫外可见光度法、荧光光谱法和线性扫描伏安法(LSV)研究了T(4-Mop)PS4与BSA之间的相互作用,并测定了二者相互作用的结合常数和结合比。研究表明,T(4-Mop)PS4与BSA之间主要以疏水作用力结合,形成了1∶1的稳定复合物。 相似文献
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以2-氯-5-硝基吡啶为原料,经甲氧基化反应得2-甲氧基-5-硝基吡啶(2),2再与液氨/高锰酸钾进行氨化反应制得2-氨基-6-甲氧基-3-硝基吡啶,总收率77%。 相似文献
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Two new triterpenoid saponins, named ginsenoside Rh10 (1) and notoginsenoside ST-6 (2), were isolated from notoginseng medicinal fungal substance. Their structures were elucidated by a combination of 1D and 2D NMR, MS and chemical analysis. 相似文献
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借模板法由6,9-二氧杂-3,12-二氮杂-十四烷-1,14-二醇分别与4-甲基(或氯)-2,6-二溴甲基苯甲醚在乙腈中, 以无水碳酸钠为缩合剂, 制得两种尚未见文献报道的含中心功能基氮支套索冠醚化合物: N,N'-二羟乙基-16-甲基-18-甲氧基-6,9-二氧杂-3,12-二氮杂-二环[12.3.1]十八-1(18),14,16-三烯(4a)和N,N'-二羟乙基-16-氯-18-甲氧基-6,9-二氧杂-3,12-二氮杂-二环[12.3.1]十八-1(18),14,16-三烯(4b)的钠离子络合物3a和3b。4a和4b经元素分析、红外光谱、核磁共振谱和质谱证实其组成和结构。借四圆衍射仪测定了3b的晶体结构和分子结构。 相似文献
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The synthesis of a thiomethyl analogue of 5-hydroxyaloin A has been achieved using benzyne and naphthyne [4 + 2] cycloadditions with substituted furans. A regiocontrolled cycloaddition was achieved using a silicon tether, and a regioselective ring opening was accomplished using a sulfide as a directing group. 相似文献