共查询到20条相似文献，搜索用时 0 毫秒
1.
2.
3.
4.
半合成头孢菌素和青霉素新衍生物的研究 总被引：2，自引：0，他引：2
将５－芳基－２Ｈ－四唑乙酰氯分别和头孢菌素母体７－ＡＣＡ，７－ＡＤＣＡ以及青霉素母体６－ＡＰＡ反应制得９种７β（５－芳基－２Ｈ－四唑乙酰胺基）头孢菌素衍生物和１种６β（５－芳基－２Ｈ－四唑乙酰胺基）青霉素衍生物，将２－苯基－４－喹啉甲酰氯分别和７－ＡＣＡ、７－ＡＤＣＡ及６－ＡＰＡ反应制得２种７β（２－苯基－４－（喹啉甲酰胺基）头孢菌素化合物，１种６β（２－苯基－４－喹啉甲酰胺基）青霉素衍生物。粗产 相似文献
5.
Tony Ly Ryan&#x;R. Julian 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2009,121(39):7266-7273
6.
7.
8.
Christian A. Olsen 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2012,124(16):3817-3819
9.
10.
Andreas Kirschning Frank Hahn 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2012,124(17):4086-4096
11.
《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(38):11688-11691
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by the aggregation of mutant huntingtin (mHtt), and removal of toxic mHtt is expected to be an effective therapeutic approach. We designed two small hybrid molecules ( 1 and 2 ) by linking a ligand for ubiquitin ligase (cellular inhibitor of apoptosis protein 1; cIAP1) with probes for mHtt aggregates, anticipating that these compounds would recruit cIAP1 to mHtt and induce selective degradation by the ubiquitin‐proteasome system. The synthesized compounds reduced mHtt levels in HD patient fibroblasts and appear to be promising candidates for the development of a treatment for HD. 相似文献
12.
Han Sun Jing Liu Shengliang Li Lingyun Zhou Jianwu Wang Libing Liu Fengting Lv Qi Gu Baoyang Hu Yuguo Ma Shu Wang 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(18):6049-6054
Protein misfolding and aberrant aggregations are associated with multiple prevalent and intractable diseases. Inhibition of amyloid assembly is a promising strategy for the treatment of amyloidosis. Reported here is the design and synthesis of a reactive conjugated polymer, a poly(p‐phenylene vinylene) derivative, functionalized with p‐nitrophenyl esters (PPV‐NP) and it inhibits the assembly of amyloid proteins, degrades preformed fibrils, and reduces the cytotoxicity of amyloid aggregations in living cells. PPV‐NP is attached to the proteins through hydrophobic interactions and irreversible covalent linkage. PPV‐NP also exhibited the capacity to eliminate Aβ plaques in brain slices in ex vivo assays. This work represents an innovative attempt to inhibit protein pathogenic aggregates, and may offer insights into the development of therapeutic strategies for amyloidosis. 相似文献
13.
14.
15.
In Semisynthesis complex molecules have to be manipulated in a chemoselective, regioselective, and stereoselective fashion, necessitating smart protective group operations and innovative synthesis development. Key are always easily accessible and suitable starting materials, especially intermediates which can be produced by biotechnological processes. An extensive synthetic construction of drug candidates carries high innovative and intellectual property protection potential, hence multistep semi‐ and even total syntheses are an integral part of modern industrial research and drug development. Not a long time ago, the complexity such realized would have been inconceivable, which profoundly illustrates the progress synthesis methodology has made. Semisynthesis always aims more toward focussed application, and hence its scientific contribution mostly cater to the elucidation of molecular correlations. Especially the study of cellular processes and their quantification will be stimulated in the future. Thereby semisynthesis will continue to bridge the key future areas of synthesis research and chemical biology. 相似文献
16.
17.
Liat Spasser Ashraf Brik 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2012,124(28):6946-6969
18.
19.
20.
《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(44):13829-13832
For many proteins, phosphorylation regulates their interaction with other biomolecules. Herein, we describe an unexpected phenomenon whereby phosphate groups are transferred non‐enzymatically from one interaction partner to the other within a binding interface upon activation in the gas phase. Providing that a high affinity exists between the donor and acceptor sites, this phosphate transfer is very efficient and the phosphate groups only ligate to sites in proximity to the binding region. Consequently, such phosphate‐transfer reactions may define with high precision the binding site between a phosphoprotein and its binding partner, as well as reveal that the binding site in this system is retained in the phase transfer from solution to the gas phase. 相似文献