On the Alkaloids of Nelumbo Nucifera Gaertn. Studies on the Alkaloids of Loti Embryo

A new tertiary tetrahydroisoquinoline alkaloid, methylcorypalline (V) and biscoclaurine base, neferine (II) were isolated from a Formosan lotus embryo (embryo of the seed of Nelumbo nucifera Gaertn.) (Nymphaeaceae), besides the earlier reported isoliensinine (I) and lotusine (IV). Characterization of this new base, methylcorypalline (I), mp. 58–59° (n-hexane), , by spectral data and direct comparison with synthetic sample prepared from vanillin have proved to be 6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (V). Methylcorypalline (V) is the first instance occurring in nature having coronary dilator action.     

狭叶百部中新生物碱的结构研究

狭叶百部(Stemona mairei Lévl)为百部科植物,产于我国云南省西北部金沙江沿岸的山坡上,民间用于止咳与润肺等。作者从云南省     

植物内生真菌生物碱活性成分的研究进展

大量的生物碱从植物内生真菌中分离了出来, 并表现出良好的生物活性. 对植物内生真菌所产生的生物碱, 按照酰胺类、有机胺类、吡咯类、喹啉和异喹啉类、吲哚类、吡啶类、喹唑啉类进行了综述, 并且介绍了这些生物碱的生物活性.     

西藜芦生物硷~1H核磁共振谱的研究

本文研究了西藜芦生物硷的1~H核磁共振谱,归纳出一些确定酰基连接位置的初步规律。     

Studies on the Alkaloids of Formosan Corydalis Species: Part III. Alkaloids of Corydalis Tashiroi Makino

Six alkaloids have been isolated from Corydalis tashirol Makino and four of these were identified as palmatine(I), dl-tetrahydropalmatine(III), I-tetrahydropalmatine(III) and protopine(V).     

Studies on the Alkaloids of Illigera Luzonensis (Presl.) Merr

From the non-phenolic base part of Illigera luzonensis (Presl.) Merr. launobine belonging to the aporphine type base was isolated.     

甘肃产三颗针植物中生物碱的测定及分布状态的研究

建立梯度洗脱双波长HPLC法同时测定小檗属植物中小檗胺、药根碱、巴马汀、小檗碱含量的方法,并应用该法分析采集于甘肃不同产地、不同品种小檗属植物的茎木、根木、茎皮、根皮样品,研究小檗属植物中生物碱的分布状态,考察其药用价值。小檗胺、药根碱、巴马汀、小檗碱线性范围分别为：0．015～2．56μg(r=0．9998);0．012～2．0μg(r=0．9996);0．010～0．52μg(r=0．9999);0．028～4．74μg(r=0．9998)。结果表明,甘肃不同产地、不同品种,不同部位三颗针植物中生物碱的含量分布有明显的差异。     

Studies on the Alkaloids of Formosan Lauraceous Plants XIX Alkaloids of lindera oldhamii hemsl. (2)

On the further investigation, N-nordicentrine(V) and L,-(+)-magnocurarine(VII) have been isolated from the trunks and leaves of Lindera oldhamii Hemsl, respectively.     

Studies on the Alkaloids of Formosan Lauraceous Plants. XVII. Alkaloids of Phoebe Formosana Hay. 1

Nine alkaloids have been isolated from the woods and the barks of Phoebe formosana Hayata and four of these have been identified with laurolitsine) (IV), roemerine (V), ushinsunine (VI) and oxoushinsunine (liriodenine) (VII).     

4种百部生物碱的质谱行为研究

对4种百部生物碱的质谱行为进行了研究。其电子轰击质谱除显示弱到中等强度的分子离子峰和特征离子[M-99] 外,其余离子丰度较弱,未能提供较多结构信息。4个化合物的电喷雾电离质谱和大气压化学电离质谱均显示强的准分子离子[M H] ,并得到特征离子[M-100] 和[M-74] 。软电离二级质谱能提供更多的结构信息。其裂解途径能体现它们的结构相似性及差异性,说明软电离质谱是百部类生物碱的结构鉴定中有效的质谱方法,将为这类生物碱的结构解析提供依据。     

纳派林类二萜生物碱研究

纳派林类化合物是一类重要的二萜生物碱,本文概述了此类化合物的化学结构,波谱特征及某些化学反应,着重介纠~1H慢~13C NMR 的特征。并列表说明所有已知的天然存在的纳派林类化合物的结构、理化性质及植物来源等。     

天然产物吲哚二酮哌嗪生物碱的结构及生物活性

吲哚二酮哌嗪生物碱是一种内生真菌次生代谢产物,多提取自曲霉属Aspergillus和青霉属Penicillium,是由不同氨基酸结合衍生而来的,在自然界分布广泛。该类化合物含有吲哚和二酮哌嗪两个母核,具有良好而广泛的生物活性,可为药物研发提供先导化合物,其新颖的结构和显著的生物活性也受到了化学全合成领域内学者的日益关注。本文主要从该类化合物的发现和化合物的结构以及化合物抗癌与抗肿瘤、抑菌、免疫调节、抗氧化及杀虫等生物活性方面对这类化合物的相关研究予以回顾,并对其结构与生物活性之间的活性构效关系进行了简要分析,为该类化合物的发现、合成及生物活性研究提供参考,并为药物研发提供借鉴。     

Studies on the Alkaloids of Formosan Lauraceous Plants. XVI.) Alkaloids of Neolitsea Variabillima (Hay.) Kanehira Et Sasaki

Three alkaloids have been isolated from the barks of Neolitsea variabilima (Hay.) Kanehira et Sasaki, and these have been identified with L-hernovine (XIII), L-nandigerine (XIV), and L-N-methylhernovine (XV) respectively.     

Synthetic Studies on the Ambiguine Family of Alkaloids: Construction of the ABCD Ring System

A racemic synthesis of the ABCD ring core of the ambiguines that preserves the tertiary alcohol has been accomplished in a convergent synthesis in 10 synthetic steps, in an overall yield of 46% from commercially available 4-bromoindole and m-methylanisole.     

复方中药四逆汤中乌头碱类二萜生物碱的电喷雾串联质谱研究

利用电喷雾串联质谱方法不经柱分离而直接分析复方中药四逆汤中二萜生物碱的组成,乌头碱类二萜生物碱在质谱条件下形成质子化分子,一种生物碱对应一个分子离子峰.检测到了苯甲酰单酯型、双酯型和脂类生物碱等18种二萜生物碱,其中苯甲酰中乌头原碱等单酯型生物碱是四逆汤中的主要生物碱成分.     

中国乌头的研究:XXIII, 紫草乌生物碱的研究

从云南紫草乌(Aconitum delavayi Franch)中又分得四个生物碱, 其中三个为新的二萜类生物碱, 分别命为紫草乌碱丙(delavaconitine C,3),紫草乌碱丁(delavaconitine D,5)和紫草乌碱戊(delavaconitime E,6),经乙酰 化、水解及UV、IR、MS、^1H和^1^3CNMR 的测定, 确定了它们的化学结构。另一个经鉴定为紫草乌碱甲胺醇(delavaconine, 2), 首次从植物中分离得到。     

Studies on the Alkaloids of Formosan Lauraceous Plants XVIII Alkaloids of Neolitsea Buisanensis Yamamoto Et Kamikoti and Neolitsea Aurata (Hay.) Koidz

Two alkaloids, laurolitsine (V) and litsericine (VII), were isolated from the woods of Neolitsea buisanersis. Six alkaloids were isolated from the woods of Neolitsea aurata and five of them were laurolitsine (V), litsericine (VII), N–methyllitsericine (VIII), (+)–anonaine (IX), and (–)-roemerine (X) (Table I).     

Studies on Natural Products from Cuban Plants. Alkaloids from Tabernaemontana citrifolia

A detailed study of the alkaloids from Tabernaemontana citrifolia, a species growing in Cuba is presented. Thirteen alkaloids were isolated and characterized. One of these, (?)-19-oxovoacristine ( 7 ), is a new compound isolated for the first lime from a natural source.     

三维同步荧光法研究喜树生物碱衍生物的荧光光谱性质

本文用三维同步荧光法详细研究了喜树生物碱衍生物的共性和特性,以及它们之间荧光光谱的变化过程,说明结构、取代基和溶剂在荧光光谱的变化中所起的作用,并用同步荧光法不经分离同时测定实际样品中的喜树碱和羟基喜树碱。