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Abstract A simple and efficient method for multicomponant synthesis of 3,4-dihydropyrimidinones has been reported. All the reactions were carried out using samarium triflate as catalyst (10 mol%) at acetonitrile reflux. This procedure is applicable to a variety of substrates such as aliphatic, aromatic, and heterocyclic aldehydes.
ACKNOWLEDGMENT
A. R. R. is thankful to the Council of Scientific and Industrial Research, New Delhi, for providing a fellowship. 相似文献2.
Abstract Less-toxic, moisture-stable, inexpensive, and ecofriendly zirconium oxychloride octahydrate (ZrOCl2 · 8H2O) in aqueous acetone (1:1) mediates the conversion of oximes to carbonyl compounds in moderate to good yields. This green methodology is applicable to both aldoximes and ketoximes with tolerance to >C?C<, -NO2, -OH, and -Cl groups. The reaction and workup are simple.
ACKNOWLEDGMENTS
LNS and AJT are grateful to the Council of Scientific and Industrial Research (CSIR), New Delhi, India, for financial support. SD thanks Tezpur University for the institutional fellowship. The support to record NMR spectra at the Indian Institute of Technology (IIT), Guwahati, is gratefully acknowledged. 相似文献3.
Ramakrishna V. S. Nirogi Rama Sastri Kambhampati Prabhakar Kothmirkar Sobhanadri Arepalli Narasimha Reddy G. Pamuleti Anil K. Shinde 《合成通讯》2013,43(19):2835-2851
Abstract Several functionalized thienopyrimidines were synthesized by a facile synthetic method, which includes Gewald's reaction, and were characterized by spectral and analytical data. These functionalized thienopyrimidines were converted to various new chemical entities of biological importance, such as 2-piperazinymethyl thienopyrimidines (6, 8), 4-dimethylaminoethoxy thienopyrimidines (11), and 3-dimethylaminoethyl thienopyrimidines (12). All the compounds thus synthesized were screened for their invitro biological activities. Some of the compounds displayed promising serotonin 5-HT6 receptor antagonist activities.
ACKNOWLEDGMENT
The support received from the Discovery Analytical Department and Venkateswarlu Jasti, CEO, Suven Life Sciences Ltd., Hyderabad, is gratefully acknowledged. 相似文献4.
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Ali Ramazani Aram Rezaei Amir Mahyari Morteza Rouhani Mehdi Khoobi Elham Yaaghubi 《合成通讯》2013,43(10):1444-1454
Abstract Addition of an isocyanide to an iminium ion intermediate that forms from the reaction between a heteroarylcarbaldehyde and a secondary amine leads to formation of sterically congested 2-(heteroaryl)acetamide derivatives in the presence of silica gel at room temperature. The structures of the products were deduced from their 1 H NMR, 13 C NMR, and infrared spectra and mass spectrometry.
ACKNOWLEDGMENT
This work was supported by the Iranian National Science Foundation. 相似文献15.
The dehydration of aldoximes and amides, and oxidation of benzoin are accomplished in one-pot using in situ–generated Burgess-type reagent.
Keywords: Amide, benzil, benzoin, Burgess reagent, Burgess-type reagent, dehydration, nitrile, oxidation, oxime
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Daniel R. Zuidema Sarah L. Williams Katherine J. Wert Karin J. Bosma Abigail L. Smith Robert C. Mebane 《合成通讯》2013,43(19):2927-2931
Aryl ketones are readily deoxygenated to their corresponding aryl alkanes upon treatment with Raney nickel catalyst in boiling 2-propanol.
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Synthesis of dibenzoxanthenes through condensation of β-naphthol with various aromatic and aliphatic aldehydes in ethanol as an ecofriendly solvent using RuIII as catalyst is reported.
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Oleksandr P. Dacenko Olga V. Manoylenko Pavel K. Mykhailiuk Dmitriy M. Volochnyuk Oleg V. Shishkin 《合成通讯》2013,43(7):981-992
An improved synthesis of Boc-monoprotected 5- and 6-amino-2-azanorbornanes is reported. The synthetic scheme consists of five steps and allows multigram quantities of the title compounds to be obtained. The regio- and stereochemistries of the products are established by two-dimensional NMR experiments.
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A new synthesis of 3-methoxypropanal from glycerol was presented. With this new approach, the conversion of glycerol to 3-methoxypropanal can be effected in moderate yield using catalysts of copper sulfate and polyethylene glycol (PEG).