共查询到20条相似文献,搜索用时 15 毫秒
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Analysis of metronidazole in equine plasma using liquid chromatography/tandem mass spectrometry and high‐resolution accurate mass spectrometry 下载免费PDF全文
Margaret Ilomuanya Cornelius Uboh John Ciallella Xiaoging Li Ying Liu Ndu Ifudu Chukwuemeka Azubuike Cecilia Igwilo 《Rapid communications in mass spectrometry : RCM》2015,29(8):753-763
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Shunsuke Horai Noriaki Yamauchi Hiroshi Naraoka 《Rapid communications in mass spectrometry : RCM》2019,33(20):1571-1577
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Putative identification of new p‐coumaroyl glycoside flavonoids in grape by ultra‐high performance liquid chromatography/high‐resolution mass spectrometry 下载免费PDF全文
Annarita Panighel Mirko De Rosso Antonio Dalla Vedova Riccardo Flamini 《Rapid communications in mass spectrometry : RCM》2015,29(4):357-366
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Threonine versus isothreonine in synthetic peptides analyzed by high‐resolution liquid chromatography/tandem mass spectrometry 下载免费PDF全文
Ksenia G. Kuznetsova Pavel V. Trufanov Alexander A. Moysa Mikhail A. Pyatnitskiy Viktor G. Zgoda Mikhail V. Gorshkov Sergei A. Moshkovskii 《Rapid communications in mass spectrometry : RCM》2016,30(11):1323-1331
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Isotope‐labeled differential profiling of metabolites using N‐benzoyloxysuccinimide derivatization coupled to liquid chromatography/high‐resolution tandem mass spectrometry 下载免费PDF全文
Michel Wagner Leanne B. Ohlund Tze Chieh Shiao Amélie Vézina Borhane Annabi René Roy Lekha Sleno 《Rapid communications in mass spectrometry : RCM》2015,29(18):1632-1640
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《Journal of separation science》2018,41(1):163-179
Gas chromatography coupled to high‐resolution mass spectrometry is a powerful analytical method that combines excellent separation power of gas chromatography with improved identification based on an accurate mass measurement. These features designate gas chromatography with high‐resolution mass spectrometry as the first choice for identification and structure elucidation of unknown volatile and semi‐volatile organic compounds. Gas chromatography with high‐resolution mass spectrometry quantitative analyses was previously focused on the determination of dioxins and related compounds using magnetic sector type analyzers, a standing requirement of many international standards. The introduction of a quadrupole high‐resolution time‐of‐flight mass analyzer broadened interest in this method and novel applications were developed, especially for multi‐target screening purposes. This review is focused on the development and the most interesting applications of gas chromatography coupled to high‐resolution mass spectrometry towards analysis of environmental matrices, biological fluids, and food safety since 2010. The main attention is paid to various approaches and applications of gas chromatography coupled to high‐resolution mass spectrometry for non‐target screening to identify contaminants and to characterize the chemical composition of environmental, food, and biological samples. The most interesting quantitative applications, where a significant contribution of gas chromatography with high‐resolution mass spectrometry over the currently used methods is expected, will be discussed as well. 相似文献
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《Rapid communications in mass spectrometry : RCM》2004,18(22):2780-2780
The original article to which this Erratum refers was published in Rapid Commun. Mass Spectrom. 2004; 18 : 2505–2512 相似文献
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Screening anti‐tumor compounds from Ligusticum wallichii using cell membrane chromatography combined with high‐performance liquid chromatography and mass spectrometry 下载免费PDF全文
Tao Zhang Yuanyuan Ding Hongli An Liuxin Feng Sicen Wang 《Journal of separation science》2015,38(18):3247-3253
Tyrosine 367 Cysteine‐fibroblast growth factor receptor 4 cell membrane chromatography combined with high‐performance liquid chromatography and mass spectrometry was developed. Tyrosine 367 Cysteine‐HEK293 cells were used as the cell membrane stationary phase. The specificity and reproducibility of the cell membrane chromatography was evaluated using 1‐tert‐butyl‐3‐{2‐[4‐(diethylamino)butylamino]‐6‐(3,5‐dimethoxyphenyl)pyrido[2,3‐d]pyrimidin‐7‐yl}urea, nimodipine and dexamethasone acetate. Then, anti‐tumor components acting on Tyrosine 367 Cysteine‐fibroblast growth factor receptor 4 were screened and identified from extracts of Ligusticum wallichii. Components from the extract were retained on the cell membrane chromatographic column. The retained fraction was directly eluted into high‐performance liquid chromatography with mass spectrometry system for separation and identification. Finally, Levistolide A was identified as an active component from Ligusticum wallichii extracts. The 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐tetrazolium bromide‐formazan colorimetric assay revealed that Levistolide A inhibits proliferation of overexpressing the mutated receptor cells with dose‐dependent manner. Phosphorylation of fibroblast growth factor receptor 4 was also decrease under Levistolide A treatment. Flex dock simulation verified that Levistolide A could bind with the tyrosine kinase domain of fibroblast growth factor receptor 4. Therefore, Levistolide A screened by the cell membrane chromatography combined with high‐performance liquid chromatography and mass spectrometry can arrest cell growth. In conclusion, the two‐dimensional high‐performance liquid chromatography method can screen and identify potential anti‐tumor ingredients that specifically act on the tyrosine kinase domain of the mutated fibroblast growth factor receptor 4. 相似文献