Cellulose sulfuric acid catalyzed one-pot three-component synthesis of imidazoazines

Imidazoazines have been synthesized by a one-pot three-component condensation reaction of an aldehyde, a 2-aminoazine and an isocyanide in the presence of the cellulose sulfuric acid, as an effective bio-supported catalyst in excellent yields. The reaction work-up is simple and the catalyst can be easily separated from the product and reused in several times.     

A green and convenient protocol for the synthesis of diarylmethanes via a one-pot,three-component reaction catalyzed by a novel silica tungstic acid (STA) under solvent-free conditions

A cost-effective and eco-friendly synthesis of diarylmethanes derivatives has been developed through the Mannich type Friedel–Crafts addition reaction of tertiary aromatic amine formaldehydes with β-naphthol/indole using silica-supported tungstic acid (STA) as a recyclable heterogeneous acid catalyst in solvent-free condition. Here, we proposed two schemes using the same catalyst. The effects of different solvents have been studied and a comparison of silica-supported tungstic acid with different acid catalysts has also been made.     

A three-component novel synthesis of 1-carbamato-alkyl-2-naphthol derivatives

A new one-pot, efficient three-component condensation of benzaldehydes, 2-naphthol, and carbamates in the presence of silica supported sodium hydrogen sulfate as an effective heterogeneous catalyst for the synthesis of novel 1-carbamato-alkyl-2-naphthol derivatives under solvent-free conditions is described. The present methodology offers several advantages, such as high yields, short reaction times, and very easy workup.     

A green one-pot synthesis of N-alkyl-2-(2-oxoazepan-1-yl)-2-arylacetamide derivatives via an Ugi four-center,three-component reaction in water

This work describes a green and efficient one-pot synthesis of N-alkyl-2-(2-oxoazepan-1-yl)-2-arylacetamide derivatives via an Ugi four-center, three-component reaction of 6-aminohexanoic acid, aromatic aldehydes, and isocyanide derivatives in water under reflux conditions in the absence of a catalyst.     

Enantioselective one-pot three-component synthesis of propargylamines catalyzed by copper(I)–pyridine bis-(oxazoline) complexes

A one-pot three-component coupling of aldehydes and amines in presence of terminal alkynes has been efficiently catalyzed by copper (I) complex of i-Pr-pybox-diPh 2b or s-Bu-pybox-diPh 2c. The process is simple and allows the synthesis of various propargylamines in good to excellent enantioselectivities (up to 99% ee) and in higher yields. The nature of the substituents attached to imines plays a vital role on the enantioselectivities obtained. The presence of gem-diphenyl group at C-5 position and secondary alkyl substituents at the C-4 chiral center of the oxazoline rings of the chiral ligands was found to be crucial for higher enantioselectivities. A transition state model involving π–π stacking is also proposed for the stereochemical outcome.     

An efficient, high yield protocol for the one-pot synthesis of dihydropyrimidin-2(1H)-ones catalyzed by iodine

The use of iodine, as a catalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones is reported.     

A one-pot, three-component synthesis of thiazolidine-2-thiones

An efficient method for the synthesis of thiazolidine-2-thiones is described via regiospecific iodocyclization of an allyl amine, carbon disulfide, and iodine. Dehydrohalogenation of the iodo-derivatives gives thiazole-2(3H)-thiones. In addition, nucleophilic substitution of the iodine in the products is accomplished using NaN₃, thiophenol, or dithiocarbamate.     

H3PMo12O40 catalyzed three-component one-pot synthesis of 4,6-diarylpyrimidin-2(1H)-ones under solvent-free conditions

<正>4,6-Diarylpyrimidin-2(1H)-one derivatives have been synthesized from three-component one-pot condensation of acetophe-none derivatives,aldehydes and urea in the presence of trimethylsilyl chloride and a catalytic amount of H_3PMo_(12)O_(40)under solvent-free conditions.     

三氯化铁催化的一锅法合成3,4-二氢嘧啶-2-酮

六水合三氯化铁催化下,β-酮酸酯、芳香醛、脲(1:1:1.5)在无水乙醇中进行环化缩合反应,合成了3,4-二氢嘧啶-2-酮衍生物,改进了Biginelli用盐酸为催化剂的一锅法反应,缩短了反应时间,操作简便,产率高达80%～90%,且Fe^3^+对环境友好。     

A novel three-component one-pot synthesis of 1H-imidazol-4-yl-pyridines

A novel three-component, one-pot condensation yielding 1H-imidazol-4-yl-pyridines from aldehydes, o-picolylamines, and isocyanides is described. The scope and limitations of the reaction have been investigated.     

ZnO nanoparticles catalyzed efficient one-pot three-component synthesis of 2,3-disubstituted quinalolin-4(1H)-ones under solvent-free conditions

ZnO nanoparticles were prepared and applied as a favorable catalyst in three-component one-pot cyclocondensation reaction of isatoic anhydride with amines and aldehydes to afford the corresponding 2,3-disubstituted quinalolin-4(1H)-ones in good yields. Reactions occurred under solvent-free conditions in high atom economy.     

A novel three-component tandem protocol for the regioselective synthesis of 1-(2-arylmethyl-5-aryl-3-thienyl)pyrrolidines and piperidines

A series of new substituted 1-(2-arylmethyl-5-aryl-3-thienyl)pyrrolidines and piperidines were synthesised by one-pot, three-component tandem reactions of 5-aryldihydro-3(2H)-thiophenone, aromatic aldehydes and pyrrolidine/piperidine under solvent-free microwave irradiation. This facile transformation occurs presumably via a tandem enamine formation-carbonyl addition-dehydration-isomerisation sequence.     

A DMAP-catalyzed mild and efficient synthesis of 1,2-dihydroquinazolines via a one-pot three-component protocol

An efficient and simple method for the synthesis of 1,2-dihydroquinazolines catalyzed by 4-(N,N-dimethylamino)pyridine (DMAP) from readily available aromatic or heteroaromatic aldehydes, 2-aminobenzophenone, and ammonium acetate under mild conditions is described. The scope and limitations of the method are discussed.     

CoCl2·6H2O催化合成3,4-二氢嘧啶-2-酮衍生物

3 ,4 二氢嘧啶 2 酮类化合物可用作钙拮抗剂、降压剂、α1ａ 拮抗物等而成为近年来生物活性有机杂环化合物研究的热点之一[1 ] 。通常该类化合物是用Ｂｉｇｉｎｅｌｉ[2 ,3] 反应得到的。为了提高其产率 ,人们作了大量的研究工作[4,1 1 ] 。本文利用Ｃｏ Ｃｌ2 6Ｈ2 Ｏ作催化剂 ,乙醇作溶剂 ,乙酰乙酸乙酯、芳香醛和脲一锅煮合成 3,4 二氢嘧啶 2 酮 ,同时考查了芳香醛的取代基及乙酰丙酮对产物收率的影响。反应方程式如下 :1　实验部分1 1　仪器与试剂熔点用毛细管法测定 ,温度计未校正。Ｅ ＱＵＩＮＯＸ5 5红外光谱仪 (ＫＢｒ压片 ) ;…     

A one-pot Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones catalyzed by triphenylphosphine as Lewis base

We report herein the use of triphenylphosphine (TPP) as a new catalyst for the one-pot Biginelli reaction coupling of β-ketoesters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones/thiones.     

无溶剂条件下碳基固体酸催化一锅法合成酰胺烷基萘酚(英文)

An efficient, environmentally friendly procedure for the synthesis of amidoalkyl naphthols through the one‐pot, three‐component reaction of β‐naphthol, aryl aldehydes, and acetamide in the presence of a carbon‐based solid acid under thermal solvent‐free conditions is described. The beneficial fea-tures of this new synthetic approach include short reaction time, high yields, clean reaction profiles, and a simple work‐up procedure. Furthermore, the catalyst can be readily recycled and reused four times without obvious significant loss of activity. The structure of the catalyst was confirmed by Fourier transform infrared spectroscopy, N2 adsorption/desorption analysis, and X‐ray diffraction.     

A facile one-pot three-component synthesis of benzylideneamino-3,5-dimethyl-1H-pyrazoles

A facile, one-pot three-component protocol for the synthesis of substituted 4-(benzylideneamino)-5-(3,5-dimethyl-1H-pyrazol-1-yl)-4H-1,2,4-triazole-3-thiols have been reported by the reaction of 4-amino-5-hydrazinyl-4H-1,2,4-triazole-3-thiol with acetyl acetone and various substituted benzaldehydes via multi component reaction. The newly synthesized derivatives were characterized by their elemental analysis and spectral data. The current strategy provides heterocyclic compounds in good yields with broad substrate scope.