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1.
非离子表面活性剂Tween 80和PEG 6000在水溶液中以一定的比例混合可形成稳定的类磷脂囊泡结构,这些囊泡可以作为模板来合成磷酸钙纳米空球颗粒。所制备的磷酸钙材料的结构和形貌通过TEM,SEM,FTIR,XRD进行了表征,是尺寸为100~150 nm左右的无定形磷酸钙空心颗粒。磷酸钙具有良好的生物相容性,因此这些具有空心结构特征的磷酸钙可发展为理想的载药体系。我们以牛血清蛋白(BSA)为模型体系研究了材料的载药和释放性能,发现所获得的空心纳米磷酸钙不仅具有良好的蛋白质负载量而且还具有优异的可释放性,明显优于传统的羟基磷灰石体系。 相似文献
2.
Xin‐Yu Zhao Prof. Dr. Ying‐Jie Zhu Feng Chen Bing‐Qiang Lu Chao Qi Jing Zhao Dr. Jin Wu 《化学:亚洲杂志》2013,8(6):1306-1312
Calcium phosphate hybrid nanoparticles (CaP‐HNPs) have been synthesized in aqueous solution through self‐assembly by using two oppositely charged polyelectrolytes (poly(diallyldimethylammonium chloride) (PDADMAC) and poly(acrylate sodium) (PAS)) as dual templates. First, the PAS/Ca2+ and PDADMAC/PO43? complexes form through electrostatic interactions and then two complexes self‐assemble into CaP‐HNPs after mixing them together. The as‐prepared CaP‐HNPs exhibit a spherical morphology with a narrow size distribution, good dispersibility, and high colloidal stability in water. The CaP‐HNPs are explored as a nanocarrier for the anticancer drug docetaxel (Dtxl). The CaP‐HNPs show excellent biocompatibility, high drug‐loading capacity, pH‐sensitive drug‐release behavior, and high anticancer effect after being loaded with Dtxl. Therefore, the as‐prepared CaP‐HNPs are promising drug nanocarriers for cancer therapy. 相似文献
3.
Chao Qi Prof. Dr. Ying‐Jie Zhu Xin‐Yu Zhao Bing‐Qiang Lu Dr. Qi‐Li Tang Jing Zhao Feng Chen 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(3):981-987
Highly stable amorphous calcium phosphate (ACP) porous nanospheres with a relatively uniform size and an average pore diameter of about 10 nm have been synthesized by using a microwave‐assisted hydrothermal method with adenosine 5′‐triphosphate disodium salt (ATP) as the phosphorus source and stabilizer. The as‐prepared ACP porous nanospheres have a high stability in the phosphate buffer saline (PBS) solution for more than 150 h without phase transformation to hydroxyapatite, and the morphology and size were essentially not changed. The important role of ATP and effects of experimental conditions on the formation of ACP porous nanospheres were also investigated. The ACP porous nanospheres were characterized by X‐ray powder diffraction (XRD), Fourier‐transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). This method is facile, rapid, surfactant‐free and environmentally friendly. The as‐prepared ACP porous nanospheres are efficient for anticancer drug (docetaxel) loading and release. The ACP porous nanosphere drug‐delivery system with docetaxel shows a high ability to damage tumor cells, thus, is promising for the application in anticancer treatment. 相似文献
4.
Microwave‐Assisted Hydrothermal Rapid Synthesis of Amorphous Calcium Phosphate Mesoporous Microspheres Using Adenosine 5′‐Diphosphate and Application in pH‐Responsive Drug Delivery
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Herein we report a rapid and green strategy for the preparation of amorphous calcium phosphate mesoporous microspheres (ACP‐MSs) using adenosine 5′‐diphosphate disodium salt (ADP) as an organic phosphorus source by a microwave‐assisted hydrothermal method. The effects of the pH value, the reaction time, and temperature on the crystal phase and morphology of the product are investigated. The ADP biomolecules used in this strategy play an important role in the formation of ACP‐MSs. The as‐prepared ACP‐MSs are efficient for anticancer drug delivery by using doxorubicin (Dox) as a model drug, and the Dox‐loaded ACP‐MSs show a high ability to damage cancer cells. Moreover, the ACP‐MSs drug delivery system exhibits a pH‐responsive drug‐release behavior due to the degradation of ACP‐MSs at a low pH value, thus, it is promising for applications in pH‐responsive drug delivery. 相似文献
5.
Dr. Bishnu Prasad Bastakoti Yin‐Chu Hsu Shih‐Hsiang Liao Prof. Kevin C.‐W. Wu Dr. Masamichi Inoue Prof. Shin‐ichi Yusa Kenichi Nakashima Prof. Yusuke Yamauchi 《化学:亚洲杂志》2013,8(6):1301-1305
Polymeric micelles consisting of asymmetric triblock copolymers were successfully used for fabrication of robust hybrid nanoparticles with highly biocompatible calcium phosphate shells. The hydrophobic polystyrene core encapsulates hydrophobic fluorescent dyes such as Nile red. The anionic polyacrylic acid provides the site for the mineralization reaction of calcium phosphate. The polyethylene glycol corona stabilizes the hybrid nanoparticles. Fluorescent dyes can be used as imaging agents for determining the location of the nanoparticles and to give an observable indication of drug delivery, while the calcium phosphate shell can enhance the fluorescence of the encapsulated dye. 相似文献
6.
DNA‐Hybrid‐Gated Multifunctional Mesoporous Silica Nanocarriers for Dual‐Targeted and MicroRNA‐Responsive Controlled Drug Delivery
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Penghui Zhang Fangfang Cheng Ri Zhou Dr. Juntao Cao Dr. Jingjing Li Prof. Dr. Clemens Burda Dr. Qianhao Min Prof. Dr. Jun‐Jie Zhu 《Angewandte Chemie (International ed. in English)》2014,53(9):2371-2375
The design of an ideal drug delivery system with targeted recognition and zero premature release, especially controlled and specific release that is triggered by an exclusive endogenous stimulus, is a great challenge. A traceable and aptamer‐targeted drug nanocarrier has now been developed; the nanocarrier was obtained by capping mesoporous silica‐coated quantum dots with a programmable DNA hybrid, and the drug release was controlled by microRNA. Once the nanocarriers had been delivered into HeLa cells by aptamer‐mediated recognition and endocytosis, the overexpressed endogenous miR‐21 served as an exclusive key to unlock the nanocarriers by competitive hybridization with the DNA hybrid, which led to a sustained lethality of the HeLa cells. If microRNA that is exclusively expressed in specific pathological cell was screened, a combination of chemotherapy and gene therapy should pave the way for a targeted and personalized treatment of human diseases. 相似文献
7.
Four‐fold Channel‐Nicked Human Ferritin Nanocages for Active Drug Loading and pH‐Responsive Drug Release
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Byungjun Ahn Seong‐Gyu Lee Hye Ryeon Yoon Dr. Jeong Min Lee Hyeok Jin Oh Prof. Ho Min Kim Prof. Yongwon Jung 《Angewandte Chemie (International ed. in English)》2018,57(11):2909-2913
Human ferritins are emerging platforms for non‐toxic protein‐based drug delivery, owing to their intrinsic or acquirable targeting abilities to cancer cells and hollow cage structures for drug loading. However, reliable strategies for high‐level drug encapsulation within ferritin cavities and prompt cellular drug release are still lacking. Ferritin nanocages were developed with partially opened hydrophobic channels, which provide stable routes for spontaneous and highly accumulated loading of FeII‐conjugated drugs as well as pH‐responsive rapid drug release at endoplasmic pH. Multiple cancer‐related compounds, such as doxorubicin, curcumin, and quercetin, were actively and heavily loaded onto the prepared nicked ferritin. Drugs on these minimally modified ferritins were effectively delivered inside cancer cells with high toxicity. 相似文献
8.
Yolk‐Shell Porous Microspheres of Calcium Phosphate Prepared by Using Calcium L‐Lactate and Adenosine 5′‐Triphosphate Disodium Salt: Application in Protein/Drug Delivery
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Guan‐Jun Ding Prof. Dr. Ying‐Jie Zhu Chao Qi Tuan‐Wei Sun Dr. Jin Wu Dr. Feng Chen 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(27):9868-9876
A facile and environmentally friendly approach has been developed to prepare yolk‐shell porous microspheres of calcium phosphate by using calcium L ‐lactate pentahydrate (CL) as the calcium source and adenosine 5′‐triphosphate disodium salt (ATP) as the phosphate source through the microwave‐assisted hydrothermal method. The effects of the concentration of CL, the microwave hydrothermal temperature, and the time on the morphology and crystal phase of the product are investigated. The possible formation mechanism of yolk‐shell porous microspheres of calcium phosphate is proposed. Hemoglobin from bovine red cells (Hb) and ibuprofen (IBU) are used to explore the application potential of yolk‐shell porous microspheres of calcium phosphate in protein/drug loading and delivery. The experimental results indicate that the as‐prepared yolk‐shell porous microspheres of calcium phosphate have relatively high protein/drug loading capacity, sustained protein/drug release, favorable pH‐responsive release behavior, and a high biocompatibility in the cytotoxicity test. Therefore, the yolk‐shell porous microspheres of calcium phosphate have promising applications in various biomedical fields such as protein/drug delivery. 相似文献
9.
Polyphosphate salts, such as sodium hexametaphosphate (PPi), are effective in the attenuation of collagenase and biofilm production and prevention of anastomotic leak in mice models. However, systemic administration of polyphosphate solutions to the gut presents a series of difficulties such as uncontrolled delivery to target and off‐site tissues. In this article a process to produce PPi‐loaded poly(ethylene glycol) diacrylate (PEGDA) hydrogel nanoparticles through miniemulsion polymerization is developed. The effects of using a polyphosphate salt, as compared to a monophosphate salt, is investigated through cloud point measurements, which is then translated to a change in the required HLB of the miniemulsion system. A parametric study is developed and yields a way to control particle swelling ratio and mean diameter based on the surfactant and/or initiator concentration, among other parameters. Finally, release kinetics of two different crosslink density particles shows a sustained and tunable release of the encapsulated polyphosphate. 相似文献
10.
Macromolecule Loading into Spherical,Elliptical, Star‐Like and Cubic Calcium Carbonate Carriers
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Dr. Bogdan V. Parakhonskiy Dr. Alexey M. Yashchenok Dr. Senem Donatan Dr. Dmitry V. Volodkin Dr. Francesco Tessarolo Prof. Renzo Antolini Prof. Helmuth Möhwald Prof. Andre G. Skirtach 《Chemphyschem》2014,15(13):2817-2822
We fabricated calcium carbonate particles with spherical, elliptical, star‐like and cubical morphologies by varying relative salt concentrations and adding ethylene glycol as a solvent to slow down the rate of particle formation. The loading capacity of particles of different isotropic (spherical and cubical) and anisotropic (elliptical and star‐like) geometries is investigated, and the surface area of such carriers is analysed. Potential applications of such drug delivery carriers are highlighted. 相似文献
11.
Wen Huang Guang Yang Qingbo Xu Meixiao Zhan Lijuan Yao Honghui Li Fengfeng Xiao Zirun Chen Xiaoguang Zhao Wenting Li Wei Zhao Fujun Zhang Yong Li Ligong Lu 《Macromolecular bioscience》2023,23(4):2200442
Developing proper wound management via wound dressings represents a global challenge. Ideal wound dressings shall encompass multiple integrated functionalities for variable, complex scenarios; however, this is challenging due to the complex molecular design and synthesis process. Herein, polymer composites, cross-linked poly(styrene oxide-co-hexaphenylcyclotrisiloxane)/crosslinked poly(hexaphenylcyclotrisiloxane) (cP(SO-co-HPCTS)/cPHPCTS) with multiple functionalities are prepared by a one-step, open-air method using catalytic ring-opening polymerization. The introduction of a mobile polymer cP(SO-co-HPCTS) endows the composite with good flexibility and self-healing properties at human body temperature. The hydrophobic groups in the main chain provide hydrophobicity and good water resistance, while the hydroxyl groups contained in the end groups enable good adhesion properties. Drugs can be efficiently loaded by blending and then sustainably release from the polymer composite. The material can rapidly degrade in a tetrahydrofuran solution of tetrabutylammonium fluoride due to its Si O Si bonds. The facile, one-step, open-air synthesis procedure and multiple functional properties integrated into the composites provide good prospects for their extensive application and batch production as wound dressing materials. 相似文献
12.
Real‐Time In Vivo Quantitative Monitoring of Drug Release by Dual‐Mode Magnetic Resonance and Upconverted Luminescence Imaging
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Dr. Jianan Liu Dr. Jiwen Bu Prof. Wenbo Bu Dr. Shengjian Zhang Dr. Limin Pan Dr. Wenpei Fan Dr. Feng Chen Prof. Liangpin Zhou Prof. Weijun Peng Prof. Kuaile Zhao Prof. Jiulin Du Prof. Jianlin Shi 《Angewandte Chemie (International ed. in English)》2014,53(18):4551-4555
Insufficient or excess drug doses, due to unknown actual drug concentrations at the focus, are one of the main causes of chemotherapy failure for cancers. In this regard, the real‐time monitoring of the release of anticancer drugs from nanoparticle drug delivery systems is of crucial importance, but it remains a critical and unsolved challenge. Herein, we report the proposal and development of a novel concept of real‐time monitoring of NIR‐triggered drug release in vitro and in vivo by using simultaneous upconverted luminescence (UCL) and magnetic resonance (MR) imaging. Such a monitoring strategy features the high sensitivity of UCL and the high‐resolution, noninvasiveness, and tissue‐depth‐independence of MR imaging. The dual‐mode real‐time and quantitative monitoring of drug release can be applied to determine online the drug concentrations in vivo in the tissue regions of interest and, therefore, to avoid insufficient or excess drug dosings. 相似文献
13.
Xin‐Yu Zhao Prof. Dr. Ying‐Jie Zhu Chao Qi Feng Chen Bing‐Qiang Lu Jing Zhao Dr. Jin Wu 《化学:亚洲杂志》2013,8(6):1313-1320
Three‐dimensional (3D) hydroxyapatite (HAP) hierarchical nanostructures, in particular hollow nanostructures, have attracted much attention owing to their potential applications in many biomedical fields. Herein, we report a rapid microwave‐assisted hydrothermal synthesis of a variety of hydroxyapatite hierarchical nanostructures that are constructed by the self‐assembly of nanorods or nanosheets as the building blocks, including HAP nanorod‐assembled hierarchical hollow microspheres (HA‐NRHMs), HAP nanorod‐assembled hierarchical microspheres (HA‐NRMs), and HAP nanosheet‐assembled hierarchical microspheres (HA‐NSMs) by using biocompatible biomolecule pyridoxal‐5′‐phosphate (PLP) as a new organic phosphorus source. The PLP molecules hydrolyze to produce phosphate ions under microwave‐hydrothermal conditions, and the phosphate ions react with calcium ions to form HAP nanorods or nanosheets; then, these nanorods or nanosheets self‐assemble to form 3D HAP hierarchical nanostructures. The preparation method reported herein is time‐saving, with microwave heating times as short as 5 min. The HA‐NRHMs consist of HAP nanorods as the building units, with an average diameter of about 50 nm. The effects of the experimental conditions on the morphology and crystal phase of the products are investigated. The hydrolysis of PLP under microwave‐hydrothermal conditions and the important role of PLP in the formation of 3D HAP hierarchical nanostructures are investigated and a possible formation mechanism is proposed. The products are explored for potential applications in protein adsorption and drug delivery. Our experimental results indicate that the HA‐NRHMs have high drug/protein‐loading capacity and sustained drug‐release behavior. Thus, the as‐prepared HA‐NRHMs are promising for applications in drug delivery and protein adsorption. 相似文献
14.
Human Serum Albumin Conjugated Nanoparticles for pH and Redox‐Responsive Delivery of a Prodrug of Cisplatin
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Hongdong Shi Qinqin Cheng Siming Yuan Xin Ding Prof. Yangzhong Liu 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(46):16547-16554
Platinum anticancer drugs are particularly in need of controlled drug delivery because of their severe side effects. Platinum(IV) agents are designed as prodrugs to reduce the side effects of platinum(II) drugs; however, premature reduction could limit the effect as a prodrug. In this work, a highly biocompatible, pH and redox dual‐responsive delivery system is prepared by using hybrid nanoparticles of human serum albumin (HSA) and calcium phosphate (CaP) for the PtIV prodrug of cisplatin. This conjugate is very stable under extracellular conditions, so that it protects the platinum(IV) prodrug in HSA. Upon reaching the acidic and hypoxic environment, the platinum drug is released in its active form and is able to bind to the target DNA. The Pt–HSA/CaP hybrid inhibits the proliferation of various cancer cells more efficiently than cisplatin. Different cell cycle arrests suggest different cellular responses of the PtIV prodrug in the CaP nanocarrier. Interestingly, this delivery system demonstrates enhanced cytotoxicity to tumor cells, but not to normal cells. 相似文献
15.
Kongyin Zhao Guoxiang Cheng Junfu Wei Jinyang Zhou Jinlong Zhang Li Chen 《Macromolecular Symposia》2010,297(1):126-137
Summary: Bovine serum albumin imprinted calcium phosphate/alginate hydrogel microspheres were prepared with sodium alginate (SA), (NH4)2HPO4, and using CaCl2 as gelling agent, bovine serum albumin (BSA) as template in inverse suspension. The optimized rebinding properties of BSA imprinted hydrogel microspheres were investigated by controlling pH value and ionic concentration from the viewpoint of adjusting the process of gelling, removing template and rebinding. The optimized pH values for the imprinting of BSA in gelling, removing template and rebinding process was 4.1, 8.3 and 4.8, respectively. The effect of NaCl concentration on the BSA rebinding was also determined. We provided a strategy to get the optimized imprinting efficiency by altering pH value and ionic concentration in a weakly ionic cross-linked hydrogel system on the process of protein's imprinting. 相似文献
16.
Chao Qi Prof. Dr. Ying‐Jie Zhu Bing‐Qiang Lu Xin‐Yu Zhao Jing Zhao Feng Chen Dr. Jin Wu 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(17):5332-5341
Hierarchically nanostructured porous hollow microspheres of hydroxyapatite (HAP) are a promising biomaterial, owing to their excellent biocompatibility and porous hollow structure. Traditionally, synthetic hydroxyapatite is prepared by using an inorganic phosphorus source. Herein, we report a new strategy for the rapid, sustainable synthesis of HAP hierarchically nanostructured porous hollow microspheres by using creatine phosphate disodium salt as an organic phosphorus source in aqueous solution through a microwave‐assisted hydrothermal method. The as‐obtained products are characterized by powder X‐ray diffraction (XRD), Fourier‐transform IR (FTIR) spectroscopy, SEM, TEM, Brunauer–Emmett–Teller (BET) nitrogen sorptometry, dynamic light scattering (DLS), and thermogravimetric analysis (TGA). SEM and TEM micrographs show that HAP hierarchically nanostructured porous hollow microspheres consist of HAP nanosheets or nanorods as the building blocks and DLS measurements show that the diameters of HAP hollow microspheres are within the range 0.8–1.5 μm. The specific surface area and average pore size of the HAP porous hollow microspheres are 87.3 m2g?1 and 20.6 nm, respectively. The important role of creatine phosphate disodium salt and the influence of the experimental conditions on the products were systematically investigated. This method is facile, rapid, surfactant‐free and environmentally friendly. The as‐prepared HAP porous hollow microspheres show a relatively high drug‐loading capacity and protein‐adsorption ability, as well as sustained drug and protein release, by using ibuprofen as a model drug and hemoglobin (Hb) as a model protein, respectively. These experiments indicate that the as‐prepared HAP porous hollow microspheres are promising for applications in biomedical fields, such as drug delivery and protein adsorption. 相似文献
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18.
Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer‐Associated Fibroblast Activation
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Tianjiao Ji Dr. Ying Zhao Dr. Yanping Ding Jing Wang Ruifang Zhao Jiayan Lang Hao Qin Xiaoman Liu Jian Shi Dr. Ning Tao Prof. Dr. Zhihai Qin Prof. Dr. Guangjun Nie Prof. Dr. Yuliang Zhao 《Angewandte Chemie (International ed. in English)》2016,55(3):1050-1055
A novel cleavable amphiphilic peptide (CAP) was designed to be specifically responsive to fibroblast activation protein‐α (FAP‐α), a protease specifically expressed on the surface of cancer‐associated fibroblasts. The CAP self‐assembled into fiber‐like nanostructures in solution, while the presence of hydrophobic chemotherapeutic drugs readily transformed the assemblies into drug‐loaded spherical nanoparticles. The disassembly of these nanoparticles (CAP‐NPs) upon FAP‐α cleavage resulted in rapid and efficient release of the encapsulated drugs specifically at tumor sites. This Transformers‐like drug delivery strategy could allow them to disrupt the stromal barrier and enhance local drug accumulation. Therapeutic results suggested that drug‐loaded CAP‐NPs hold promising tumor specificity and therapeutic efficacy for various solid tumor models, confirming its potential utility and versatility in antitumor therapy. 相似文献
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Vijayendra Kumar Bhavna Gupta Gaurav Kumar Mukesh K. Pandey Eric Aiazian Virinder S. Parmar 《高分子科学杂志,A辑:纯化学与应用化学》2013,50(12):1154-1160
Amphiphilic polymers can self assemble into micellar nano-particles and can be effectively used as nano carriers for drug delivery. A number of macromolecular delivery systems are under investigation to improve the efficacy of prospective drugs. In this study, seven new co-polymers were synthesized under mild reaction conditions in bulk (without solvent) by chemoenzymatic approach using Candida antarctica lipase (Novozyme 435) and molecular sieves, subsequently these polymers were treated with different long chain bromoalkanes and acid chlorides for attachment of the lipophilic moieties to the backbone polymer via an ether or an ester linkage, respectively in order to make them amphiphilic. These synthesized nano-particles demonstrated high drug loading capacity and have the potential to encapsulate hydrophobic drugs. 相似文献