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Thanikasalam Kanagasabapathy Panchanatheswaran Krishnaswamy Jeyaraman Ramasubbu 《Acta Crystallographica. Section C, Structural Chemistry》2009,65(11):o579-o582
rac‐5‐Diphenylacetyl‐2,2,4‐trimethyl‐2,3,4,5‐tetrahydro‐1,5‐benzothiazepine, C26H27NOS, (I), and rac‐5‐formyl‐2,2,4‐trimethyl‐2,3,4,5‐tetrahydro‐1,5‐benzothiazepine, C13H17NOS, (II), are both characterized by a planar configuration around the heterocyclic N atom. In contrast with the chair conformation of the parent benzothiazepine, which has no substituents at the heterocyclic N atom, the seven‐membered ring adopts a boat conformation in (I) and a conformation intermediate between boat and twist‐boat in (II). The molecules lack a symmetry plane, indicating distortions from the perfect boat or twist‐boat conformations. The supramolecular architectures are significantly different, depending in (I) on C—H...O interactions and intermolecular S...S contacts, and in (II) on a single aromatic π–π stacking interaction. 相似文献
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Rafael Germano Santana Derisvaldo Rosa Paiva Roberto da Silva Gomes Adriana Karla C. A. Reis 《Magnetic resonance in chemistry : MRC》2013,51(5):316-319
The complete assignment of the 1H and 13C NMR spectra of various 2‐acetamido‐3‐mercapto‐3‐methyl‐N‐aryl‐butanamides and 2‐acetamide‐3‐methyl‐3‐nitrososulfanyl‐N‐aryl‐butanamides with p‐methoxy, o‐chloro and m‐chloro substituents is reported. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
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Clair Bilton Judith A. K. Howard N. N. Laxmi Madhavi Gautam R. Desiraju Frank H. Allen 《Acta Crystallographica. Section C, Structural Chemistry》2000,56(11):1356-1358
The title compounds, C8H10O2, (I), and C12H14O2, (II), occurred as by‐products in the controlled synthesis of a series of bis(gem‐alkynols), prepared as part of an extensive study of synthon formation in simple gem‐alkynol derivatives. The two 4‐(gem‐alkynol)‐1‐ones crystallize in space group P21/c, (I) with Z′ = 1 and (II) with Z′ = 2. Both structures are dominated by O—H?O=C hydrogen bonds, which form simple chains in the cyclohexane derivative, (I), and centrosymmetric dimers, of both symmetry‐independent molecules, in the cyclohexa‐2,5‐diene, (II). These strong synthons are further stabilized by C[triple‐bond]C—H?O=C, Cmethylene—H?O(H) and Cmethyl—H?O(H) interactions. The direct intermolecular interactions between donors and acceptors in the gem‐alkynol group, which characterize the bis(gem‐alkynol) analogues of (I) and (II), are not present in the ketone derivatives studied here. 相似文献
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István Kádas Gábor Szántó László Tőke AndrÁS Simon Gábor Tóth 《Journal of heterocyclic chemistry》2007,44(6):1373-1381
The 1,3‐dipolar‐cycloadditions of two kind of isoquinolinium and carbolinium ylides with fumaric and maleic nitrile resulted in pyrroloisoquinoline and indolizino[8,7‐b]indole derivatives, respectively, which are analogues of biologically active alkaloids. The cycloadditions were performed in good yield and proved to be stereoselective. The structure elucidation and complete 1H and 13C assignments have been achieved by a combination of various one‐ and two‐dimensional NMR experiments. 相似文献
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Katarzyna
lepokura Monika Gawowska 《Acta Crystallographica. Section C, Structural Chemistry》2005,61(1):o25-o28
The title amidino‐amino acids (a‐Hpro), C6H11N3O3·H2O, (I), and a‐Met, C6H13N3O2S·H2O, (II), respectively, exist in the form of zwitterions. The five‐membered pyrrolidine ring in (I) adopts an envelope conformation, with the Cγ atom out of the plane defined by the rest of the ring atoms, and with the hydroxyl and carboxylate groups in a trans configuration relative to the ring plane. The two crystallographically independent zwitterions in (II) reveal quite different conformations of their side chains and a slightly different orientation of the guanidine moiety with respect to the carboxylate group. The crystal structures of both (I) and (II) are stabilized by extensive networks of O—H·O, N—H·O and C—H·O hydrogen bonds, the network being three‐dimensional in (I) and two‐dimensional in (II). 相似文献
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Vladimir N. Nesterov David J. Wiedenfeld Svitlana V. Nesterova Lucas F. Hastings 《Acta Crystallographica. Section C, Structural Chemistry》2006,62(12):o705-o708
The syntheses, X‐ray structural investigations and calculations of the conformational preferences of the carbonyl substituent with respect to the pyran ring have been carried out for the two title compounds, viz. C15H14N2O2, (II), and C20H16N2O2·C2H3N, (III), respectively. In both molecules, the heterocyclic ring adopts a flattened boat conformation. In (II), the carbonyl group and a double bond of the heterocyclic ring are syn, but in (III) they are anti. The carbonyl group forms a short contact with a methyl group H atom in (II). The dihedral angles between the pseudo‐axial phenyl substituent and the flat part of the pyran ring are 92.7 (1) and 93.2 (1)° in (II) and (III), respectively. In the crystal structure of (II), intermolecular N—H⋯N and N—H⋯O hydrogen bonds link the molecules into a sheet along the (103) plane, while in (III), they link the molecules into ribbons along the a axis. 相似文献
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Peng Wu Xiao‐Mei Liang Jian‐Jun Zhang Yue‐Mei Jia Yan‐Hong Dong Jia‐Xing Huang Fu‐Heng Chen Dao‐Quan Wang 《Helvetica chimica acta》2009,92(12):2774-2782
15‐Cyano‐12‐oxopentadecano‐15‐lactone was synthesized in 59% total yield starting from 2‐nitrocyclododecanone by Michael addition to acrylaldehyde, followed by reaction with trimethylsilylcyanide, hydrolysis, ring‐expansion, and Nef reaction. A two‐step, one‐pot synthesis of intermediate 2‐hydroxy‐4‐(1‐nitro‐2‐oxycyclododecyl)butanenitrile from 3‐(1‐nitro‐2‐oxocyclododecyl)propanal was developed and the conditions for the Nef reaction were studied. 15‐Cyano‐12‐oxopentadecano‐15‐lactam was synthesized in 40% total yield starting from 2‐nitrocyclododecanone by Michael addition to acrylaldehyde, followed by Strecker reaction, ring‐expansion, and Nef reaction. The conditions for the Strecker and Nef reactions were studied. The structures of the target compounds, intermediates, and by‐product were characterized by IR, 1H‐ and 13C‐NMR, and elemental analysis or MS. 相似文献
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Jun Ling Wei Chen Zhiquan Shen 《Journal of polymer science. Part A, Polymer chemistry》2005,43(9):1787-1796
Dihydroxyl capped biodegradable poly(DTC‐b‐PEG‐b‐DTC) (BCB) triblock copolymer and poly(TMC‐b‐DTC‐b‐PEG‐b‐DTC‐b‐TMC) (ABCBA) pentablock copolymer have been synthesized by PEG and BCB copolymer as macroinitiator in the presence of yttrium tris(2,6‐di‐tert‐butyl‐4‐methylphenolate). The copolymers without random segments have been thoroughly characterized by 1H, 13C‐NMR, SEC, and DSC. Molecular weights of the obtained copolymers are dependent on the amount of PEGs and coincide with the theoretical values. The exchange reaction of yttrium alkoxide and hydroxyl end group is essential for controlling the products' molecular weight. Their thermal behaviors are relevant to the chain lengths of PEG and PDTC segments. The Monte Carlo method has been developed to estimate the chain propagation constant and exchange reaction constant. In average, one exchange reaction will occur after approximately six monomer molecules insert into the growing chain. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 1787–1796, 2005 相似文献
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Syntheses and Fluorescent Properties of 6‐Methoxy‐2‐oxoquinoline‐3,4‐dicarbonitriles and 6,7‐Dimethoxy‐2‐oxoquinoline‐3,4‐dicarbonitriles 下载免费PDF全文
Guy Crépin Enoua Günther Lahm Georg Uray Wolfgang Stadlbauer 《Journal of heterocyclic chemistry》2014,51(Z1):E263-E275
4‐Chlorocarbostyrils 3 , 12 , 17 , 24 , 26 with methoxy substituents in 6, 7, or 6,7‐position react with potassium cyanide in a p‐toluenesulfinate mediated reaction either to the highly fluorescent and stable 2‐oxoquinoline‐3,4‐dicarbonitriles 6 , 27 , 29 , 30 or at slightly lower temperatures to 4‐monocarbonitriles 5 , 13 , 18 . 4‐Chlorocarbostyril 3 and lithium p‐toluenesulfinate gave pure 4‐toluenesulfonylquinolone 4 , which reacted with potassium cyanide either to monocarbonitrile 5 or dicarbonitrile 6 , depending on the reaction conditions. 4‐Trifluoromethylquinolones 9 and 19 were prepared for fluorescence comparison from the appropriate methoxyaniline and 4,4,4‐trifluoroacetoacetate. The fluorescence properties such as emission wavelengths and quantum yields of 6‐methoxyderivatives 4 , 5 , 6 , 9 , 13 were studied and compared with those of 7‐methoxy derivatives 18 , 19 and 6,7‐dimethoxyderivatives 27 , 28 , 29 , 30 . 6,7‐Dimethoxy derivatives show best results, showing long‐waved fluorescence spectra up to 520 nm and acceptable quantum yields up to 0.46 for 3,4‐dicyano derivative 27 excited at 440 nm in acetonitrile. 相似文献
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Hong Song Wei‐Bing Feng Feng Cheng De‐Qing Shi 《Journal of heterocyclic chemistry》2013,50(6):1381-1385
Two series of novel 4‐acyl‐2,5‐disubstituted‐3‐hydroxypyrazoles 3a , 3b , 3c , 3d , 3e , 3f , 3g , 3h and 4‐arylcarbonyl‐3‐substitutedisoxazol‐5‐ones 7a , 7b , 7c , 7d , 7e , 7f , 7g , 7h , 7i were synthesized by the Scotton–Baumann reaction of 2,5‐disubstituted‐2,4‐dihydro‐pyrazol‐3‐ones 1 or 3‐substituted‐4H‐isoxazol‐5‐ones 6 and various acyl chlorides, followed by the Fries rearrangement in the presence of calcium hydroxide and calcium oxide as the catalyst. Their structures were confirmed by IR, 1H NMR, mass spectroscopy, and elemental analyses. 1H NMR indicated that compounds 3 existed in enol forms and compounds 7 in keto configurations. The results of preliminary bioassays showed that some of the title compounds 3 and 7 exhibited moderate to good herbicidal activities against Brassica campestris L. at the concentration of 100 mg/L. Isoxazole compounds 7 showed better herbicidal activity against B. campestris L. than pyrazole compounds 3 did at the concentration of 100 mg/L. Moreover, most of the isoxazole compounds displayed higher herbicidal activity against B. campestris L. than Echinochloa crus‐galli. However, these compounds showed weak herbicidal activities at the concentration of 10 mg/L. 相似文献
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Jan Fbry Michal Duek Pemysl Vank Iegor Rafalovskyi Jií Hlinka Jií Urban 《Acta Crystallographica. Section C, Structural Chemistry》2014,70(12):1153-1160
The structures of 4‐chloro‐3‐nitroaniline, C6H5ClN2O2, (I), and 4‐iodo‐3‐nitroaniline, C6H5IN2O2, (II), are isomorphs and both undergo continuous (second order) phase transitions at 237 and 200 K, respectively. The structures, as well as their phase transitions, have been studied by single‐crystal X‐ray diffraction, Raman spectroscopy and difference scanning calorimetry experiments. Both high‐temperature phases (293 K) show disorder of the nitro substituents, which are inclined towards the benzene‐ring planes at two different orientations. In the low‐temperature phases (120 K), both inclination angles are well maintained, while the disorder is removed. Concomitantly, the b axis doubles with respect to the room‐temperature cell. Each of the low‐temperature phases of (I) and (II) contains two pairs of independent molecules, where the molecules in each pair are related by noncrystallographic inversion centres. The molecules within each pair have the same absolute value of the inclination angle. The Flack parameter of the low‐temperature phases is very close to 0.5, indicating inversion twinning. This can be envisaged as stacking faults in the low‐temperature phases. It seems that competition between the primary amine–nitro N—H...O hydrogen bonds which form three‐centred hydrogen bonds is the reason for the disorder of the nitro groups, as well as for the phase transition in both (I) and (II). The backbones of the structures are formed by N—H...N hydrogen bonding of moderate strength which results in the graph‐set motif C(3). This graph‐set motif forms a zigzag chain parallel to the monoclinic b axis and is maintained in both the high‐ and the low‐temperature structures. The primary amine groups are pyramidal, with similar geometric values in all four determinations. The high‐temperature phase of (II) has been described previously [Garden et al. (2004). Acta Cryst. C 60 , o328–o330]. 相似文献
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Marius Bruvoll Selma Dizdarevic Nina Fimland Jasmina Hafizovic Carl Henrik Grbitz Helen Therese Kalfjs Kristian Vestli Alexander Krivokapic 《Acta Crystallographica. Section C, Structural Chemistry》2006,62(1):o22-o25
The structures of the title dipeptides, C9H18N2O4·0.33H2O, C12H16N2O4 and C8H16N2O4S·0.34H2O, complete a series of investigations focused on l ‐Xaa‐l ‐serine peptides, where Xaa is a hydrophobic residue. All three structures are divided into hydrophilic and hydrophobic layers. The hydrophilic layers are thin for l ‐phenylalanyl‐l ‐serine, rendered possible by an unusual peptide conformation, and thick for l ‐isoleucyl‐l ‐serine and l ‐methionyl‐l ‐serine, which include cocrystallized water molecules on the twofold axes. 相似文献
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Shailesh K. Goswami Lyall R. Hanton C. John McAdam Stephen C. Moratti Jim Simpson 《Acta Crystallographica. Section C, Structural Chemistry》2013,69(4):407-411
The title compounds, C11H11BrO3, (I), and C11H11NO5, (II), respectively, are derivatives of 6‐hydroxy‐5,7,8‐trimethylchroman‐2‐one substituted at the 5‐position by a Br atom in (I) and by a nitro group in (II). The pyranone rings in both molecules adopt half‐chair conformations, and intramolecular O—H...Br [in (I)] and O—H...Onitro [in (II)] hydrogen bonds affect the dispositions of the hydroxy groups. Classical intermolecular O—H...O hydrogen bonds are found in both molecules but play quite dissimilar roles in the crystal structures. In (I), O—H...O hydrogen bonds form zigzag C(9) chains of molecules along the a axis. Because of the tetragonal symmetry, similar chains also form along b. In (II), however, similar contacts involving an O atom of the nitro group form inversion dimers and generate R22(12) rings. These also result in a close intermolecular O...O contact of 2.686 (4) Å. For (I), four additional C—H...O hydrogen bonds combine with π–π stacking interactions between the benzene rings to build an extensive three‐dimensional network with molecules stacked along the c axis. The packing in (II) is much simpler and centres on the inversion dimers formed through O—H...O contacts. These dimers are stacked through additional C—H...O hydrogen bonds, and further weak C—H...O interactions generate a three‐dimensional network of dimer stacks. 相似文献
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Rafal Kruszynski Agata Trzesowska‐Kruszynska 《Acta Crystallographica. Section C, Structural Chemistry》2010,66(9):o449-o454
In the title compounds, C7H6ClN2O+·NO3− and C7H6ClN2O+·ClO4−, the ions are connected by N—H...O hydrogen bonds and halogen interactions. Additionally, in the first compound, co‐operative π–π stacking and halogen...π interactions are observed. The energies of the observed interactions range from a value typical for very weak interactions (1.80 kJ mol−1) to one typical for mildly strong interactions (53.01 kJ mol−1). The iminium cations exist in an equilibrium form intermediate between exo‐ and endocyclic. This study provides structural insights relevant to the biochemical activity of 2‐amino‐5‐chloro‐1,3‐benzoxazole compounds. 相似文献