Partial angle inversion recovery (PAIR) MR imaging: spin-echo and snapshot implementation.

The effects of varying the inversion or excitation RF pulse flip angles on image contrast and imaging time have been investigated in IR imaging theoretically, with phantoms and with normal volunteers. Signal intensity in an IR pulse sequence as a function of excitation, inversion and refocusing pulse flip angles was calculated from the solution to the Bloch equations and was utilized to determine the contrast behavior of a lesion/liver model. Theoretical and experimental results were consistent with each other. With the TI chosen to suppress the fat signal, optimization of the excitation pulse flip angle results in an increase in lesion/liver contrast or allows reduction in imaging time which, in turn, can be traded for an increased number of averages. This, in normal volunteers, improved spleen/liver contrast-to-noise ratio (9.0 vs. 5.7, n = 8, p less than 0.01) and suppressed respiratory ghosts by 33% (p less than 0.01). Reducing or increasing the inversion pulse from 180 degrees results in shorter TI needed to null the signal from the tissue of interest. Although this decreases the contrast-to-noise ratio, it can substantially increase the number of sections which can be imaged per given TR in conventional IR imaging or during breathold in the snapshot IR (turboFLASH) technique. Thus, the optimization of RF pulses is useful in obtaining faster IR images, increasing the contrast and/or increasing the number of imaging planes.     

Variable flip angle imaging and fat suppression in combined gradient and spin-echo (GREASE) techniques

Conventional "proton density" and "T2-weighted" spin-echo images are susceptible to motion induced artifact, which is exacerbated by lipid signals. Gradient moment nulling can reduce motion artifact but lengthens the minimum TE, degrading the "proton density" contrast. We designed a pulse sequence capable of optimizing proton density and T2-weighted contrast while suppressing lipid signals and motion induced artifacts. Proton density weighting was obtained by rapid readout gradient reversal immediately after the excitation RF pulse, within a conventional spin-echo sequence. By analyzing the behavior of the macroscopic magnetization and optimizing excitation flip angle, we suppressed T1 contribution to the image, thereby enhancing proton density and T2-weighted contrast with a two- to four-fold reduction of repetition time. This permitted an increased number of averages to be used, reducing motion induced artifacts. Fat suppression in the presence of motion was investigated in two groups of 8 volunteers each by (i) modified Dixon technique, (ii) selective excitation, and (iii) hybrid of both. Elimination of fat signal by the first technique was relatively uniform across the field of view, but it did not fully suppress the ghosts originating from fat motion. Selective excitation, while sensitive to the main field inhomogeneity, largely eliminated the ghosts (0.21 +/- 0.05 vs. 0.29 +/- 0.06, p less than 0.01). The hybrid of both techniques combined with bandwidth optimization, however, showed the best results (0.17 +/- 0.04, p less than 0.001). Variable flip-angle imaging allows optimization of image contrast which, along with averaging and effective fat suppression, significantly improves gradient- and spin-echo imaging, particularly in the presence of motion.     

Contrast variation in spin-echo small angle neutron scattering

The use of contrast variation in spin-echo small angle neutron scattering (SESANS) experiments is discussed for the case of colloidal structural investigation. On the basis of calculations for several model systems, we find that the contrast variation SESANS technique, in terms of the measured SESANS correlation function G(z), is not sensitive to the structural characteristics of colloidal suspensions consisting of particles with uniform scattering length density profiles. However, its ability to resolve structural heterogeneity, at both intra-colloidal and inter-colloidal length scales, is clearly demonstrated. The prospect of using this new technique to investigate structural information that is difficult to probe in other ways is also explored.     

Polarized neutron imaging: A spin-echo approach

Polarized neutron imaging has recently been introduced as an efficient method to three-dimensionally visualize and measure magnetic fields even in the bulk of massive objects. Here we introduce a spin-echo approach for polarized neutron imaging, which has the potential to overcome some drawbacks of the first attempts, namely to deal with strong fields, arbitrary field directions and quantification. Furthermore our novel approach increases the efficiency of quantitative studies due to relaxed monochromatisation requirements for spin-echo neutron imaging and with respect to additional information available in the recorded images, which allows for straightforward quantification in many cases.     

Fast flair imaging of the brain using the fast spin-echo and gradient spin-echo technique

The purpose of this study was to compare the gradient spin-echo (GRASE) to the fast spin-echo (FSE) implementation of fast fluid-attenuated inversion recovery (FLAIR) sequences for brain imaging. Thirty patients with high signal intensity lesions on T₂-weighted images were examined on a 1.5 T MR system. Scan time-minimized thin-section FLAIR-FSE and FLAIR-GRASE sequences were obtained and compared side by side. Image assessment criteria were lesion conspicuity, contrast between different types of normal tissue, image quality, and artifacts. In addition, contrast ratios and contrast-to-noise ratios were determined. Compared to FSE, the GRASE technique allowed a 17% reduction in scan time but conspicuity of small lesions in particular was significantly lower on FLAIR-GRASE images because of higher image noise and increased artifacts. Gray-white differentiation was slightly worse on FLAIR-GRASE. Physiological ferritin deposition appeared slightly darker on FLAIR-GRASE images and susceptibility artifacts were stronger. Fatty tissue was less bright with FLAIR-GRASE. With current standard hardware equipment, the GRASE technique is not an adequate alternative to FSE for the implementation of fast FLAIR sequences in routine clinical MR brain imaging.     

Factors influencing contrast in fast spin-echo MR imaging.

Multi-echo pulse sequences for producing T2-weighted images in much reduced imaging times have recently been developed for routine clinical use. A number of recent articles have described the contrast obtained with fast spin-echo (FSE) sequences and have generally indicated that they depict tissues very similarly to conventional spin-echo (SE) imaging. There are, however, some important differences in contrast between some tissues in FSE images. This work presents a detailed study of the contrast obtained with FSE imaging sequences and examines the image sequence and tissue parameters which influence contrast. The use of multiple refocusing pulses produces several subtle effects not seen in conventional SE imaging sequences, and in this study the precise nature and extent of such effects are described. The relative contributions to image contrast of magnetization transfer, the decoupling of J-modulation effects, the production of stimulated echoes and direct saturation effects, of diffusion and of the effects of the differential attenuation of different spatial frequencies, are each quantified. The mechanisms responsible for the brighter fat signal seen in FSE images, as well as the loss of signal from some other tissues, are explained. Computer simulations, phantom experiments, and clinical images are all used to support the conclusions.     

Microscopic displacement imaging with pulsed field gradient turbo spin-echo NMR

We present a pulse sequence that enables the accurate and spatially resolved measurements of the displacements of spins in a variety of (biological) systems. The pulse sequence combines pulsed field gradient (PFG) NMR with turbo spin-echo (TSE) imaging. It is shown here that by ensuring that the phase of the echoes within a normal spin-echo train is constant, displacement propagators can be generated on a pixel-by-pixel basis. These propagators accurately describe the distribution of displacements, while imaging time is decreased by using separate phase encoding for every echo in a TSE train. Measurements at 0.47 T on two phantoms and the stem of an intact tomato plant demonstrate the capability of the sequence to measure complete and accurate propagators, encoded with 16 PFG steps, for each pixel in a 128 x 128 image (resolution 117 x 117 x 3,000 microm) within 17 min. Dynamic displacement studies on a physiologically relevant time resolution for plants are now within reach.     

Multi-shot turbo spin-echo for 3D vascular space occupancy imaging

Vascular space occupancy (VASO) is a magnetic resonance imaging technique sensitive to cerebral blood volume, and is a potential alternative to the blood oxygenation level dependent (BOLD) sensitive technique as a basis for functional mapping of the neurovascular response to a task. Many implementations of VASO have made use of echo-planar imaging strategies that allow rapid acquisition, but risk introducing potentially confounding BOLD effects. Recently, multi-slice and 3D VASO techniques have been implemented to increase the imaging volume beyond the single slice of early reports. These techniques usually rely, however, on advanced scanner software or hardware not yet available in many centers. In the present study, we have implemented a short-echo time, multi-shot 3D Turbo Spin-Echo (TSE) VASO sequence that provided 8-slice coverage on a routine clinical scanner. The proposed VASO sequence was tested in assessing the response of the human motor cortex during a block design finger tapping task in 10 healthy subjects. Significant VASO responses, inversely correlated with the task, were found at both individual and group level. The location and extent of VASO responses were in close correspondence to those observed using a conventional BOLD acquisition in the same subjects. Although the spatial coverage and temporal resolution achieved were limited, robust and consistent VASO responses were observed. The use of a susceptibility insensitive volumetric TSE VASO sequence may have advantages in locations where conventional BOLD and echo-planar based VASO imaging is compromised.     

Large angle electroproduction of electron-positron pairs

Cross section of electron-positron pair electroproduction for large angles with the colliding e⁺-e⁻ beams is calculated. The result obtained is in good agreement with the experiment.     

Improved contrast at 1.5 tesla using half-Fourier imaging: application to spin-echo and angiographic imaging

Half-Fourier imaging is useful for reducing imaging time by requiring less than the usual number of phase-encoding steps. This increase in speed can be traded off for longer repeat times, TR, for improved contrast-to-noise in the same imaging time or to collect short asymmetric echoes. Consequently, it is shown to be especially useful for long TR spin-echo imaging where at 1.5 T a repeat time of 4 sec is recommended for a double-echo TE = 30/90 sequence or 3 sec for a double-echo TE = 15/90 sequence. Short TR FLASH imaging also benefits from a longer TR since there is more time to spoil the signal. In both cases, there is the advantage when a multislice acquisition mode is used that more slices (and hence, a larger volume) can be taken. Another application is to apply half-Fourier imaging in the read direction to avoid spin dephasing and motion artifacts. This is particularly useful in angiographic imaging where smaller pixel sizes and shorter echo times both reduce pixel dephasing. Again, even though taking less than the usual number of data points leads to a reduction in S/N, the improved signal and resolution for blood vessels can more than compensate this loss.     

Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C

Dynamic nuclear polarization of metabolically active compounds labeled with (13)C has been introduced as a means for imaging metabolic processes in vivo. To differentiate between the injected compound and the various metabolic products, an imaging technique capable of separating the different chemical-shift species must be used. In this paper, the design and testing of a pulse sequence for rapid magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized (13)C is presented. The pulse sequence consists of a small-tip excitation followed by a double spin echo using adiabatic refocusing pulses and a "flyback" echo-planar readout gradient. Key elements of the sequence are insensitivity to calibration of the transmit gain, the formation of a spin echo giving high-quality spectral information, and a small effective tip angle that preserves the magnetization for a sufficient duration. Experiments in vivo showed three-dimensional coverage with excellent spectral quality and SNR.     

The influence of stimulated echoes on contrast in fast spin-echo imaging

Tissue contrast obtained using fast spin-echo (FSE) and conventional spin-echo (SE) sequences is not identical and a number of mechanisms are thought to contribute to these contrast differences. The effect of stimulated echoes has previously been apparently ruled out as a contributing mechanism. Signal-to-noise ratios of single-slice matched FSE and conventional SE sequences were compared in aqueous solutions of CuSO₄, Cr₂(SO₄)₃ and MnSO₄ with various T₁ and T₂ values. Enhancement of the FSE signal was observed in short T₂ solutions and the effect was greater in samples where the T₁ to T₂ ratio was high. Reducing the refocusing pulse flip angle to increase the contribution from stimulated echoes also resulted in slightly increased enhancement. Experimental results were verified by computer simulations. Our results show that stimulated echoes do contribute to the contrast differences between FSE and conventional SE images and may be significant in the imaging of brain hemorrhage.     

Large angle hadron correlations from medium-induced gluon radiation

Final state medium-induced gluon radiation in ultradense nuclear matter is examined and shown to favor large angle emission when compared to vacuum bremsstrahlung due to the suppression of collinear gluons. Perturbative expression for the contribution of its hadronic fragments to the back-to-back particle correlations is derived. It is found that in the limit of large jet energy loss gluon radiation determines the yield and angular distribution of dihadrons to high transverse momenta p_T2 of the associated particles. Clear transition from enhancement to suppression of the away-side hadron correlations is established at moderate p_T2 and its experimentally accessible features are predicted versus the trigger particle momentum p_T1.     

Multiple spin-echo MR imaging of the body: image contrast and motion-induced artifact

For a given TR and TE, image quality changes when the number of spin echoes obtained is varied. To investigate the importance of this in clinical imaging, a total of 4 patients and 9 volunteers had MRI examinations of the abdomen (n = 7) and/or pelvis (n = 8) which included at least 2 sequences with identical TR (2000 or 2500 ms), TE (80 ms) and other parameters, but with a different series of refocusing pulses. Sequences included single-echo (S), asymmetric and symmetric double-echo (AD and SD) and quadruple-echo (Q) techniques. Image contrast and severity of motion-induced artifact was measured via blind examination by 3 independent MRI radiologists and calculation of signal-difference, signal-difference-to-noise ratios and intensity of motion-induced "ghost artifact." The order of decreasing signal differences was S, SD, AD and Q, and all of three liver lesions were better seen with S than with SD techniques. These observations are consistent with signal loss from cumulative inaccuracies from multiple 180 degrees RF pulses. The order of increasing intensity of ghost artifact was Q, SD, AD and S, consistent with the beneficial motion artifact-reducing effects of even-echo rephasing. Knowledge of these effects of multi-echo imaging allows one to make informed decisions about imaging protocols rather than to simply obtain multiple echoes "because they are free."     

Pelvic phased array coil: image quality assessment for spin-echo MR imaging.

The NMR phased array coil (PA) provides improved signal-to-noise ratio (SNR) over that available with the body coil. We evaluated image quality obtained with a pelvic PA compared to that obtained with the body coil for spin-echo imaging. Thirty-three women undergoing clinical pelvic MRI were imaged with the body coil followed by imaging with the PA with the same field-of-view (FOV) in 11 patients, and with a small FOV in 23 patients. Image quality was assessed independently by two radiologists. In individual cases there was significant improvement in image quality with the PA, however the expected marked improvement in image quality was not consistently found. Two factors which may limit image quality are increased motion artifact and nonuniformity of signal with distance from the coils. Significant improvements in image quality may occur with improved techniques to decrease motion artifact.     

MR knee imaging: axial 3DFT GRASS pulse sequence versus spin-echo imaging for detecting meniscal tears.

The knees of 17 patients (34 menisci) referred for magnetic resonance (MR) imaging to evaluate knee pain were examined using thin axial three-dimensional Fourier transform (3DFT) gradient-refocused acquisition in a steady state (GRASS) images through the menisci, to determine if this method is sensitive and specific for detecting meniscal tears. Results were compared with spin-echo images with long TR and double-echo TE in both coronal and sagittal planes. Arthroscopy results, available in each case, were used as the "gold standard." Twelve meniscal tears were identified at arthroscopy. Axial 3DFT GRASS technique detected 10 of the 12 meniscal tears compared to 9 or 12 using spin-echo technique. With axial 3DFT GRASS technique one false-positive meniscal tear was reported, compared with two false-positive tears on spin-echo images. Axial 3DFT GRASS images were very useful in detecting peripheral tears, showing displaced meniscal fragments, and evaluating complex tears. In this small study, thin axial 3DFT GRASS images were comparable to spin-echo images for detecting meniscal tears, and were helpful in complicated cases in which they provided complementary information to that obtained from spin-echo images.