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Urinary excretion of acetylsalicylic acid in man 总被引:1,自引:0,他引:1
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W M Teller 《Nature》1967,213(5081):1132-1133
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Circadian rhythm of gastric acid secretion in man 总被引:3,自引:0,他引:3
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Greenland Eskimos who live on a traditional marine diet rich in long chain omega 3-polyunsaturated fatty acids have a low incidence of cardiovascular disease and myocardial infarction. In their plasma and platelet lipids, arachidonic acid, the precursor of dienoic prostanoids, is partly replaced by eicosapentaenoic acid (C20:5, omega 3; EPA), the precursor of trienoic prostanoids. Studies with an Eskimo diet or a Western diet supplemented with sea fish or fish oil rich in EPA resulted in an 'Eskimo-like' pattern of plasma and platelet lipids. Moreover, less reactive platelets, a reduced ex vivo formation of proaggregatory thromboxane A2 and a blunted circulatory response to pressor hormones were reported. These favourable functional effects may be induced by a shift of prostanoid formation from the dienoic to the trienoic series. We show here that the major urinary metabolite of endogenous prostaglandin I3 is present in subjects that have ingested either cod liver oil (approximately 4 g EPA per day) or mackerel (approximately 10-15 g EPA per day). Our studies provide the first direct evidence for in vivo formation of prostaglandin I3 in man. 相似文献
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Urinary phenols in melanoma 总被引:1,自引:0,他引:1
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Urinary metabolites in Parkinson's disease 总被引:1,自引:0,他引:1
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Urinary amines in chronic schizophrenia 总被引:1,自引:0,他引:1
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Metabolism of coumarin in man 总被引:3,自引:0,他引:3