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1.
V. A. Tartakovsky A. S. Ermakov D. B. Vinogradov P. V. Bulatov 《Russian Chemical Bulletin》1998,47(4):652-655
Nitration ofN-3-chloroalkoxy-2-hydroxypropyl-N-alkylsulfamates gave the correspondingN-3-chloroalkoxy-2-nitroxypropyl-N-alkylnitramines. Azidation of the latter resulted inN-azido-3-azidoalkoxypropyl-N-alkylnitramines.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 673–676, April, 1998. 相似文献
2.
It was shown that 3-alkoxy-2-nitroxypropyl-N-alkylnitramines can be prepared by nitration of the corresponding 3-alkoxy-2-hydroxypropyl-N-alkylsulfamates.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 1987–1989, November, 1997. 相似文献
3.
T. V. Mikhalina S. V. Rubashko E. P. Fokin I. Yu. Bagryanskaya Yu. V. Gatilov 《Russian Chemical Bulletin》1995,44(12):2346-2349
It was shown that the reaction of 2-chloro-3-(4-N,N-dimethylaminoanilino)-1,4-naphthoquinone with piperidine in the absence of a solvent gives not only a product of replacement of the chlorine atom by a piperidino group, 3-(4-N,N-dimethylaminoanilino)-2-piperidino-1,4-naphthoquinone, but also 2-(4-N,N-dimethylaminoanilino)-1,4-naphthoquinone and 2-(4-N,N-dimethylaminoanilino-2-piperidino)-1,4-naphthoquinone. The latter compounds are the only reaction products formed in dimethyl sulfoxide. The reaction with morpholine occurs in a similar way, whereas that with pyrrolidine gives only a product of replacement of the chlorine atom by hydrogen.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2451–2454, December, 1995. 相似文献
4.
The geometric parameters, the charge distribution, and the energetics of N-methyl-2-(N-ethylanilino)-3-(indol-1-yl)-and N-methyl-2-(N-ethylanilino)-3-(indol-3-yl)maleimides and their conjugated acids were studied by density functional theory calculations
at the B3LYP/6-31G(d) level. The mechanism of the tandem hydride transfer/cyclization sequence, which occurs after protonation
of N-methyl-2-(N-ethylanilino)-3-(indol-1-yl)-and N-methyl-2-(N-ethylanilino)-3-(indol-3-yl)maleimides, was analyzed. The investigation of the potential energy surface for the tandem hydride
transfer/cyclization of the iminium cation that formed upon protonation revealed that the hydride transfer followed by intramolecular
cyclization at position 7 of the indole fragment in N-methyl-2-(N-ethylanilino)-3-(indol-1-yl)maleimide is the preferable process, unlike alternative intramolecular cyclization involving
the cationic center at the C(2) atom of the indole fragment and the benzene ring of the N-ethylaniline fragment of the indoleninium cation in N-methyl-2-(N-ethylanilino)-3-(indol-3-yl)maleimide. A study of the key intermediates of the assumed reaction mechanism demonstrated that
these intermediates are actually stationary points on the potential energy surface (minima and transition states).
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2069–2073, December, 2006. 相似文献
5.
T. M. Ugurchieva A. V. Lozanova M. V. Zlokazov V. V. Veselovsky 《Russian Chemical Bulletin》2007,56(8):1544-1549
trans-Stereoselective electrophilic cyclization of (2R*,SS*)-N, N-diisopropyl-2-phenylsulfinylpent-4-enamide under the action of bromine afforded (3R*,5S*, SS*)-N-(5-bromomethyl-3-phenylsulfinyltetrahydrofuran-2-ylidene)-N,N-diisopropylammonium bromide. Its transformations under the conditions of hydrolysis, dehydrobromination, and hydride reduction
were studied.
Dedicated to Academician V. A. Tartakovsky on the occasion of his 75th birthday.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1485–1490, August, 2007. 相似文献
6.
1-(N-alkylnitraminomethyl)-3-nitroureas were prepared by nitration of condensation products of urea with formaldehyde andN-alkylsulfamate.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2041–2042, November, 1994. 相似文献
7.
S. Yu. Ryabova A. S. Shashkov L. M. Alekseeva E. A. Lisitsa V. G. Granik 《Russian Chemical Bulletin》2007,56(8):1595-1602
The reactions of 3-[N-chloracetylamino-N-(4-nitrophenyl)]-2-formylindole (1a) with 2-(N, N-dialkylamino)ethylamines afford complex condensation products 7b,c consisting of two similar but not identical diazepinoindole fragments. For the reaction of compound 1a with 3-(N,N-diethylamino)propylamine, the process occurs in a different manner, and the predominant product is 4-ethylaminopropyl-1-(4-nitrophenyl)-2-oxo-1,2,3,4,5,6-hexahydro[1,4]diazepino[6,5-b]indole hydrocloride (14). Two routes of these unexpected transformations were proposed. The structures of the synthesized products were proved by
the 1sH and 13C NMR, HMBC, and HSQC (direct proton-carbon correlation) spectra.
Dedicated to Academician V. A. Tartakovsky on the occasion of his 75th birthday.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1536–1542, August, 2007. 相似文献
8.
Summary 3(Bis(alkylthio)methylene)-3H-isobenzofuran-1-ones2a–e and 2-(bis(alkylthio)methylene)-3(2H)-benzofuranone derivatives4a–c are obtained by reaction of phthalides1a–d or 3(2H)-benzofuranone (coumaranone3), respectively, with carbon disulfide under basic conditions followed by alkylation. The reaction behaviour of the new compounds2 and4 is investigated. 2-((2-Dimethylthio-1-oxo)ethyl)benzoic acid N,N-dimethylamide (7a) and 2-((2-dimethylthio-1-oxo)ethyl)-benzoic acid 2-methylpiperidide (7b) are surprisingly formed instead of the methylthio substitution products by treatment of2a with the corresponding amine in the presence of aluminum chloride.
Herrn Professor Dr. Dr. h. c.Waldemar Adam zum 60. Geburtstag gewidmet 相似文献
9.
Substituted 2-amino-4-aryl-3-cyano-5-oxo-5,6-dihydro-4H-pyrano[2,3-d]pyrido[3",2":4,5]thieno[3,2-b]pyridines were synthesized by the reactions of 4-hydroxy-1H-thieno[2,3-b;4,5-b]dipyridin-2-ones with arylidenemalononitriles or by the three-component reactions of hydroxythienodipyridinones with aldehydes and malononitrile in DMF in the presence of triethylamine. Methods for syntheses of substituted 3-alkoxycarbonyl-6-amino-4-aryl-2-(3-cyanopyridin-2-ylthiomethyl)-4H-pyrans were developed on the basis of the reactions of 4-(3-cyanopyridin-2-ylthio)acetoacetates and arylidenemalononitriles or aldehydes and malononitrile. Ethyl 4-(3-cyanopyridin-2-ylthio)acetoacetate and 4-methoxybenzylidenecyanothioacetamide were used for the synthesis of 6-(pyridin-2-ylthiomethyl)-3-cyanopyridine-2(1H)-thione. 相似文献
10.
B. S. Fedorov N. I. Golovina V. V. Arakcheeva M. A. Fadeev G. V. Strukov V. V. Kedrov G. V. Shilov L. O. Atovmyan 《Russian Chemical Bulletin》1999,48(8):1584-1586
The reaction ofN,N′-bis(2-nitroxyethyl)pyridine-2,6-dicarboxamide with PdCl2 afforded previously unknowncis-(N-2-nitroxyethylpicolinamide-N,N′)dichloropalladium(II) andcis-[2-(2-pyridyl)-2-oxazoline-N,N′]dichloropalladium(II), which were isolated as a cocrystallizate of the molecular compounds. Its structure was established
by X-ray diffraction analysis.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1604–1606, August, 1999. 相似文献
11.
Shubhangi C. Joshi Kunjbihari N. Trivedi 《Monatshefte für Chemie / Chemical Monthly》1992,123(6-7):557-564
Summary The Claisen rearrangement of 7-(3-phenyl-2-propenyloxy)-3-phenyl-(4H)-1-benzopyran-4-one (2 a) gave 7-hydroxy-8-(1-phenyl-2-propenyl)-3-phenyl-(4H)-1-benzopyran-4-one (3 a) and 2,3-dihydro-2,6-diphenyl-3-methyl-(7H)furo[2,3-h]-1-benzopyran-7-one (7 a). 2-Methyl-7-(3-phenyl-2-propenyloxy)-3-phenyl-(4H)-1-benzopyran-4-one (2 b) afforded4 b and7 b. 8-Methyl-7-(3-phenyl-2-propenyloxy)-3-phenyl-(4H)-1-benzopyran-4-one (12) gave only the alkali soluble product 7-hydroxy-8-methyl-6-(1-phenyl-2-propenyl)-3-phenyl-(4H)-1-benzopyran-4-one (13).3 a,4 b, and13 were further cyclized in acidic medium to9 a,10 b, and14 followed by dehydrogenation.This paper is dedicated to Dr. F. M. Dean, Department of Organic Chemistry, Robert Robinson Laboratories, University of Liverpool, Liverpool, U. K., on his retirement 相似文献
12.
N′-(取代嘧啶-2-基)-N-菊酰硫脲的合成与生物活性研究 总被引:7,自引:0,他引:7
采用活性基团拼接法, 将第一菊酸构型中的最高活性组分(+)-反式菊酸以及二氯菊酸引入到含取代嘧啶环的酰基硫脲结构中, 合成了5个未见文献报道的N′-(取代嘧啶-2-基)-N-(+)-反式菊酰硫脲衍生物(3a~3e)和3个均未见文献报道的N′-(取代嘧啶-2-基)-N-二氯菊酰硫脲(3f~3h), 结构经元素分析、IR和1H NMR得到确证. 初步的生物活性测试结果表明: 大部分化合物具有较好的杀菌活性, 有的化合物兼具除草和杀菌活性, 有的化合物兼具杀虫和杀菌活性. 相似文献
13.
Salts ofN-(β-hydroxyalkyl)-N′-hydroxydiazeneN-oxides, RCH(OH)CH2N(O)=NO− M+ (R=Me, Pri, or But; and M=Li, Na, K, Ag, NH4, or Me4N), were prepared. Their alkylation with alkyl halides R′X (X=Cl, Br, or I) and dimethyl sulfate was studied. Generally, alkylation
afforded mixtures ofN-(β-hydroxyalkyl)-N′-alkoxydiazeneN-oxides RCH(OH)CH2N(O)=NOR′ andO-alkyl-N-(β-hydroxyalkyl)-N-nitrosohydroxylamines RCH(OH)CH2N(NO)OR′.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1996–2001, October, 1998. 相似文献
14.
The reaction of 6-(tert-butyl)-3-hydrazino-1,2,4-triazin-5(2H)-one with acetone and benzaldehyde yields the corresponding hydrazones. In the presence of thionyl chloride the benzaldehyde hydrazone is converted to 3-(tert-butyl)-6-phenyl-1,2,4-triazolo[4,3-b]-1,2,4-triazin-2(1H)-one and this can also be formed via the acylation of the starting hydrazinotriazinone using benzoyl chloride. 相似文献
15.
S. G. Krivokolysko V. D. Dyachenko V. N. Nesterov V. P. Litvinov 《Chemistry of Heterocyclic Compounds》2001,37(7):855-860
The reaction of o-iodobenzaldehyde, cyanothioacetamide, and N-acetoacetyl-o-toluidine in the presence of piperidine gave piperidinium 4,5-trans-3-cyano-6-hydroxy-4-(2-iodophenyl)-6-methyl-5-(2-methylphenyl)carbamoyl-1,4,5,6-tetrahydropyridine-2-thiolate used in the synthesis of substituted 4,5-trans-2-alkylthiotetrahydropyridines and 2-(2-thiazolyl)acrylonitriles. The structure of 3-(2-iodophenyl)-2-(4-phenyl-2-thiazolyl)acrylonitrile was studied using X-ray diffraction structural analysis. 相似文献
16.
N-(Aroylarnmomethylfglycine amides were synthesized by reactions ofN-(aroyllminomethyl) glycine esters with ammonia. Alkaline hydrolysis ofN-(amidomethyl)glycine,N-(irnidornethyl)glycine, andN-(amidomethyl)pheriylalariiiie esters afforded the correspondingN-(amidowthyVa-amirio acids- Reactions of the Last-mentioned compounds with ethyl esters of glycine, alanine, and phenylalanine in the presence of dicyclohexylcarbodiimide yielded dipeptides containingNh-amidomethyl substituents.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1770–1771, July, 1996. 相似文献
17.
Palladium(0)/copper iodide catalyzed Sonogashira cross-coupling of 2-aryl-3-iodo-4-(phenylamino)quinolines with terminal alkynes afforded series of 1,2,4-trisubstituted 1H-pyrrolo[3,2-c]quinolines in a single-step operation. Conversely, the 4-(N,N-allylphenylamino)-2-aryl-3-iodoquinoline derivatives were found to undergo PdCl2(PPh3)2/CuI catalyzed intramolecular Heck reaction to yield the corresponding 1,3,4-trisubstituted 1H-pyrrolo[3,2-c]quinolines. 相似文献
18.
A new synthesis ofE- andZ(-)(1R,3S)-2,2-dimethyl-3-(3,3,3-trifluoro-2-chloropropen1-yl)cyclopropanecarboxylic acids from (+)-3-carene in 21 % total yield was carried out.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 517–518, March, 1995. 相似文献
19.
The initial reaction mechanisms of N-(2- chloroethyl)-N-nitrosourea (CENU) decomposition have been investigated at the MP2/6-311+G(d,p) level. The mechanistic processes considered
were the hydrogen shifting from the nitrogen to the oxygen of the nitroso group, the oxygen of the nitroso and the carbonyl
groups nucleophilic displacing the chlorine. The computational results showed that the energy barrier of retro-ene reaction
was lower in the gas phase than that of substitution reactions. In the solvent, however, the energy values of each barrier
in these three processes approach each other. It is concluded that the CENU decomposition in solvent can proceed via retro-ene
reaction and intramolecular substitution reactions. 相似文献
20.
Interaction of 3-(benzimidazolyl-2)-2-iminocoumarins with aromatic aldehydes in the presence of piperidine gave the corresponding 7-aryl-7H-benzo[4,5]imidazo[1,2-c]benzopyrano[3,2-e]pyrimidines. The 3-diethylamino derivatives of this series fluoresce effectively in alcohol solutions. 相似文献