Formation of microcracks in an indented Ti<Subscript>3</Subscript>Al intermetallic compound

Microcracks in the Ti₃Al alloy indented at room temperature have been analyzed by electron microscopy. Analysis of the microstructure has revealed that microcracks propagate in the {0\(\overline 1 \)11} pyramidal planes and in the slip bands of the 2c + a superdislocations in the {20\(\overline 2 \)1} and {11\(\overline 2 \)1} pyramidal planes. It is found that the formation of a slip band in the basal plane at the microcrack tip leads to a change in the character of microcrack propagation from straight-line to steplike.     

Equilibration in the Kac Model Using the GTW Metric $$d_2$$

We use the Fourier based Gabetta–Toscani–Wennberg metric \(d_2\) to study the rate of convergence to equilibrium for the Kac model in 1 dimension. We take the initial velocity distribution of the particles to be a Borel probability measure \(\mu \) on \(\mathbb {R}^n\) that is symmetric in all its variables, has mean \(\vec {0}\) and finite second moment. Let \(\mu _t(dv)\) denote the Kac-evolved distribution at time t, and let \(R_\mu \) be the angular average of \(\mu \). We give an upper bound to \(d_2(\mu _t, R_\mu )\) of the form \(\min \left\{ B e^{-\frac{4 \lambda _1}{n+3}t}, d_2(\mu ,R_\mu )\right\} ,\) where \(\lambda _1 = \frac{n+2}{2(n-1)}\) is the gap of the Kac model in \(L^2\) and B depends only on the second moment of \(\mu \). We also construct a family of Schwartz probability densities \(\{f_0^{(n)}: \mathbb {R}^n\rightarrow \mathbb {R}\}\) with finite second moments that shows practically no decrease in \(d_2(f_0(t), R_{f_0})\) for time at least \(\frac{1}{2\lambda }\) with \(\lambda \) the rate of the Kac operator. We also present a propagation of chaos result for the partially thermostated Kac model in Tossounian and Vaidyanathan (J Math Phys 56(8):083301, 2015).     

Regularity of the Speed of Biased Random Walk in a One-Dimensional Percolation Model

We consider biased random walks on the infinite cluster of a conditional bond percolation model on the infinite ladder graph. Axelson-Fisk and Häggström established for this model a phase transition for the asymptotic linear speed \(\overline{\hbox {v}}\) of the walk. Namely, there exists some critical value \(\lambda _{\hbox {c}}>0\) such that \(\overline{\hbox {v}}>0\) if \(\lambda \in (0,\lambda _{\hbox {c}})\) and \(\overline{\hbox {v}}=0\) if \(\lambda \ge \lambda _{\hbox {c}}\). We show that the speed \(\overline{\hbox {v}}\) is continuous in \(\lambda \) on \((0,\infty )\) and differentiable on \((0,\lambda _{\hbox {c}}/2)\). Moreover, we characterize the derivative as a covariance. For the proof of the differentiability of \(\overline{\hbox {v}}\) on \((0,\lambda _{\hbox {c}}/2)\), we require and prove a central limit theorem for the biased random walk. Additionally, we prove that the central limit theorem fails to hold for \(\lambda \ge \lambda _{\hbox {c}}/2\).     

Thermodynamic implications of the gravitationally induced particle creation scenario

A rigorous thermodynamic analysis has been done as regards the apparent horizon of a spatially flat Friedmann–Lemaitre–Robertson–Walker universe for the gravitationally induced particle creation scenario with constant specific entropy and an arbitrary particle creation rate \(\Gamma \). Assuming a perfect fluid equation of state \(p=(\gamma -1)\rho \) with \(\frac{2}{3} \le \gamma \le 2\), the first law, the generalized second law (GSL), and thermodynamic equilibrium have been studied, and an expression for the total entropy (i.e., horizon entropy plus fluid entropy) has been obtained which does not contain \(\Gamma \) explicitly. Moreover, a lower bound for the fluid temperature \(T_f\) has also been found which is given by \(T_f \ge 8\left( \frac{\frac{3\gamma }{2}-1}{\frac{2}{\gamma }-1}\right) H^2\). It has been shown that the GSL is satisfied for \(\frac{\Gamma }{3H} \le 1\). Further, when \(\Gamma \) is constant, thermodynamic equilibrium is always possible for \(\frac{1}{2}<\frac{\Gamma }{3H} < 1\), while for \(\frac{\Gamma }{3H} \le \text {min}\left\{ \frac{1}{2},\frac{2\gamma -2}{3\gamma -2} \right\} \) and \(\frac{\Gamma }{3H} \ge 1\), equilibrium can never be attained. Thermodynamic arguments also lead us to believe that during the radiation phase, \(\Gamma \le H\). When \(\Gamma \) is not a constant, thermodynamic equilibrium holds if \(\ddot{H} \ge \frac{27}{4}\gamma ^2 H^3 \left( 1-\frac{\Gamma }{3H}\right) ^2\), however, such a condition is by no means necessary for the attainment of equilibrium.     

On quantum analogue of dynamical stabilisation of inverted harmonic oscillator by time periodical uniform field

Quantum analogue of stabilised forced oscillations around an unstable equilibrium position is explored by solving the non-stationary Schrödinger equation (NSE) of the inverted harmonic oscillator (IHO) driven periodically by spatial uniform field of frequency \(\Omega \), amplitude \(F_{0}\) and phase \(\phi \), i.e. the system with the Hamiltonian of \(\hat{{H}}=(\hat{{p}}^{2}/2m)-(m\omega ^{2}x^{2}/2)-F_0 x\sin \) \(\left( {\Omega t+\phi } \right) \). The NSE has been solved both analytically and numerically by Maple 15 in dimensionless variables \(\xi = x\sqrt{m\omega /\hbar }\hbox {, }f_0 =F_0 /\omega \sqrt{\hbar m\omega }\) and \(\tau =\omega t\). The initial condition (IC) has been specified by the wave function (w.f.) of a generalised Gaussian type which suits well the corresponding quantum IC operator. The solution obtained demonstrates the non-monotonous behaviour of the coordinate spreading \(\sigma \left( \tau \right) \hbox { =}\sqrt{\big ( {\overline{\Delta \xi ^{2}\big ( \tau \big )} } \big )}\) which decreases first from quite macroscopic values of \(\sigma _{0} =2^{12,\ldots ,25}\) to minimal one of \(\sim \!(1/\sqrt{2})\) at times \(\tau <\tau _0 =0.125\ln \!\left( {16\sigma _0^4 +1} \right) \) and then grows back unlimitedly. For certain phases \(\phi \) depending on the \(\Omega /\omega \) ratio and \(n=\log _2\!\sigma _0 \), the mass centre of the packet \(\xi _{\mathrm {av}}( \tau )= \overline{\hat{{x}}(\tau )} \cdot \sqrt{m\omega /\hbar }\) delays approximately two natural ‘periods’ \(\sim \!(4\pi /\omega )\) in the area of the stationary point and then escapes to ‘\(+\)’ or ‘?’ infinity in a bifurcating way.  For ‘resonant’ \(\Omega =\omega \), the bifurcation phases \(\phi \) fit well with the regression formula of Fermi–Dirac type of argument n with their asymptotic \(\phi ( {\Omega ,n\rightarrow \infty } )\) obeying the classical formula \(\phi _{\mathrm {cl}} ( \Omega )=-\hbox {arctg} \, \Omega \) for initial energy \(E = 0\) in the wide range of \(\Omega =2^{-4},...,2^{7}\).     

Critical Two-Point Function for Long-Range <Emphasis Type="Italic">O</Emphasis>(<Emphasis Type="Italic">n</Emphasis>) Models Below the Upper Critical Dimension

We consider the n-component \(|\varphi |^4\) lattice spin model (\(n \ge 1\)) and the weakly self-avoiding walk (\(n=0\)) on \(\mathbb Z^d\), in dimensions \(d=1,2,3\). We study long-range models based on the fractional Laplacian, with spin-spin interactions or walk step probabilities decaying with distance r as \(r^{-(d+\alpha )}\) with \(\alpha \in (0,2)\). The upper critical dimension is \(d_c=2\alpha \). For \(\varepsilon >0\), and \(\alpha = \frac{1}{2} (d+\varepsilon )\), the dimension \(d=d_c-\varepsilon \) is below the upper critical dimension. For small \(\varepsilon \), weak coupling, and all integers \(n \ge 0\), we prove that the two-point function at the critical point decays with distance as \(r^{-(d-\alpha )}\). This “sticking” of the critical exponent at its mean-field value was first predicted in the physics literature in 1972. Our proof is based on a rigorous renormalisation group method. The treatment of observables differs from that used in recent work on the nearest-neighbour 4-dimensional case, via our use of a cluster expansion.     

Skeletal modifications of $$\upbeta $$-carboline alkaloids and their antiviral activity profile

To study the effect of the variation of fused ring size and substitution on the antiviral activity of \(\upbeta \)-carboline alkaloids, four types of structurally novel \(\upbeta \)-carboline alkaloids analogues, with indole-fused six- to nine-membered-rings motifs, were designed, synthesized, and evaluated for the inhibition of tobacco mosaic virus (TMV). Bioassay results indicated that most of these analogues had significant anti-TMV activity; especially I-14 (54 \(\pm \) 3 % at 500 \(\upmu \)g/mL in vitro; 51 \(\pm \) 2, 45 \(\pm \) 2, and 42 \(\pm \) 1 % at 500 \(\upmu \)g/mL in vivo), II-4 (53 \(\pm \) 1 % at 500 \(\upmu \)g/mL in vitro; 49 \(\pm \) 2, 57 \(\pm \) 2, and 48 \(\pm \) 1 % at 500 \(\upmu \)g/mL in vivo), and II-8 (48 \(\pm \) 1 % at 500 \(\upmu \)g/mL in vitro; 53 \(\pm \) 2 %, 56 \(\pm \) 2 %, and 46 \(\pm \) 1 % at 500 \(\upmu \)g/mL in vivo), which were more potent vs. TMV than was ribavirin (36 \(\pm \) 1 % at 500 \(\upmu \)g/mL in vitro; 37 \(\pm \) 2, 41 \(\pm \) 2, and 38 \(\pm \) 1 % at 500 \(\upmu \)g/mL in vivo). The size of the fused ring has important effects on anti-TMV potency, which may be ascribed to conformational differences. The X-ray structures of I-1, I-6, II-8, and III show differing conformational preferences. The most potent compounds can be used as leads for further optimization as antiphytoviral agents.     

High-precision Q<Subscript>EC</Subscript> -value measurements for superallowed decays

The superallowed \( \beta\) -decay \(\ensuremath Q_\mathrm{EC}\) -value measurement program at JYFLTRAP has been very fruitful with 14 \(\ensuremath Q_\mathrm{EC}\) values of outstanding precision measured between 2005 and 2010, when the IGISOL and JYFLTRAP facilities were shut down for relocation.     

Warm modified Chaplygin gas shaft inflation

In this paper, we examine the possible realization of a new inflation family called “shaft inflation” by assuming the modified Chaplygin gas model and a tachyon scalar field. We also consider the special form of the dissipative coefficient \(\Gamma ={a_0}\frac{T^{3}}{\phi ^{2 }}\) and calculate the various inflationary parameters in the scenario of strong and weak dissipative regimes. In order to examine the behavior of inflationary parameters, the \(n_s \)–\( \phi ,\, n_s \)–r, and \(n_s \)–\( \alpha _s\) planes (where \(n_s,\, \alpha _s,\, r\), and \(\phi \) represent the spectral index, its running, tensor-to-scalar ratio, and scalar field, respectively) are being developed, which lead to the constraints \(r< 0.11\), \(n_s=0.96 \pm 0.025\), and \(\alpha _s =-0.019 \pm 0.025\). It is quite interesting that these results of the inflationary parameters are compatible with BICEP2, WMAP \((7+9)\) and recent Planck data.     

Photoreflectance spectroscopy of the chalcopyrite semiconductor <Emphasis Type="Bold">AgInS</Emphasis><Subscript>2</Subscript> for ordinary and extraordinary rays

Photoreflectance spectra have been measured on the chalcopyrite semiconductor silver indium disulfide (\(\hbox {AgInS}_{2}\)) for light polarization \({\varvec{E}}\) perpendicular (\({\varvec{E}} \bot {c}\)) and parallel to the c-axis (\({\varvec{E}} \vert \vert {c}\)) at temperature between 10 and 300 K. The measured photoreflectance spectra revealed distinct structures at 1.8–2.1 eV. The lowest bandgap energies \(E_{0A}\), \(E_{0B}\), and \(E_{0C}\) of \(\hbox {AgInS}_{2}\) show unusual temperature dependence at low temperatures (\(\le\)140 K). The \(E_{0\alpha }\) (\(\alpha =A, B, C\)) is found to increase with increasing temperature from 10 to \(\sim\)140 K and decreases with a further increase in temperature. This result has been successfully explained by taking into account the effects of thermal expansion and electron–phonon interaction. The spin–orbit and crystal-field splitting parameters of \(\hbox {AgInS}_{2}\) are determined to be \(\Delta _{{\mathrm{so}}}=38\) meV and \(\Delta _{{\mathrm{cr}}}=-168\) meV at T = 10 K, respectively, and are discussed from an aspect of the electronic energy band structure consequences. The temperature dependence of spin–orbit and crystal-field splitting parameters of \(\hbox {AgInS}_{2}\) was also presented.     

Likelihood analysis of the pMSSM11 in light of LHC 13-TeV data

We use MasterCode to perform a frequentist analysis of the constraints on a phenomenological MSSM model with 11 parameters, the pMSSM11, including constraints from \(\sim 36\)/fb of LHC data at 13 TeV and PICO, XENON1T and PandaX-II searches for dark matter scattering, as well as previous accelerator and astrophysical measurements, presenting fits both with and without the \((g-2)_\mu \) constraint. The pMSSM11 is specified by the following parameters: 3 gaugino masses \(M_{1,2,3}\), a common mass for the first-and second-generation squarks \(m_{\tilde{q}}\) and a distinct third-generation squark mass \(m_{\tilde{q}_3}\), a common mass for the first-and second-generation sleptons \(m_{\tilde{\ell }}\) and a distinct third-generation slepton mass \(m_{\tilde{\tau }}\), a common trilinear mixing parameter A, the Higgs mixing parameter \(\mu \), the pseudoscalar Higgs mass \(M_A\) and \(\tan \beta \). In the fit including \((g-2)_\mu \), a Bino-like \(\tilde{\chi }^0_{1}\) is preferred, whereas a Higgsino-like \(\tilde{\chi }^0_{1}\) is mildly favoured when the \((g-2)_\mu \) constraint is dropped. We identify the mechanisms that operate in different regions of the pMSSM11 parameter space to bring the relic density of the lightest neutralino, \(\tilde{\chi }^0_{1}\), into the range indicated by cosmological data. In the fit including \((g-2)_\mu \), coannihilations with \(\tilde{\chi }^0_{2}\) and the Wino-like \(\tilde{\chi }^\pm _{1}\) or with nearly-degenerate first- and second-generation sleptons are active, whereas coannihilations with the \(\tilde{\chi }^0_{2}\) and the Higgsino-like \(\tilde{\chi }^\pm _{1}\) or with first- and second-generation squarks may be important when the \((g-2)_\mu \) constraint is dropped. In the two cases, we present \(\chi ^2\) functions in two-dimensional mass planes as well as their one-dimensional profile projections and best-fit spectra. Prospects remain for discovering strongly-interacting sparticles at the LHC, in both the scenarios with and without the \((g-2)_\mu \) constraint, as well as for discovering electroweakly-interacting sparticles at a future linear \(e^+ e^-\) collider such as the ILC or CLIC.     

Domain and Range of the Modified Wave Operator for Schrödinger Equations with a Critical Nonlinearity

We study the final problem for the nonlinear Schrödinger equation

$i{\partial }_{t}u+\frac{1}{2}\Delta u=\lambda|u|^{\frac{2}{n}}u,\quad (t,x)\in {\mathbf{R}}\times \mathbf{R}^{n},$

where\(\lambda \in{\bf R},n=1,2,3\). If the final data\(u_{+}\in {\bf H}^{0,\alpha }=\left\{ \phi \in {\bf L}^{2}:\left( 1+\left\vert x\right\vert \right) ^{\alpha }\phi \in {\bf L}^{2}\right\} \) with\(\frac{ n}{2} < \alpha < \min \left( n,2,1+\frac{2}{n}\right) \) and the norm\(\Vert \widehat{u_{+}}\Vert _{{\bf L}^{\infty }}\) is sufficiently small, then we prove the existence of the wave operator in L ². We also construct the modified scattering operator from H ^0,α to H ^0,δ with\(\frac{n}{2} < \delta < \alpha\).

     

Pinning down neutrino oscillation parameters in the 2–3 sector with a magnetised atmospheric neutrino detector: a new study

We determine the sensitivity to neutrino oscillation parameters from a study of atmospheric neutrinos in a magnetised detector such as the ICAL at the proposed India-based Neutrino Observatory. In such a detector, which can separately count \(\nu _\mu \) and \(\overline{\nu }_\mu \)-induced events, the relatively smaller (about 5%) uncertainties on the neutrino–antineutrino flux ratios translate to a constraint in the \(\chi ^2\) analysis that results in a significant improvement in the precision with which neutrino oscillation parameters such as \(\sin ^2\theta _{23}\) can be determined. Such an effect is unique to all magnetisable detectors and constitutes a great advantage in determining neutrino oscillation parameters using such detectors. Such a study has been performed for the first time here. Along with an increase in the kinematic range compared to earlier analyses, this results in sensitivities to oscillation parameters in the 2–3 sector that are comparable to or better than those from accelerator experiments where the fluxes are significantly higher. For example, the \(1\sigma \) precisions on \(\sin ^2\theta _{23}\) and \(|\Delta {m^2_{32(31)}}|\) achievable for 500 kton year exposure of ICAL are \({\sim }9\) and \({\sim }2.5\)%, respectively, for both normal and inverted hierarchies. The mass hierarchy sensitivity achievable with this combination when the true hierarchy is normal (inverted) for the same exposure is \(\Delta \chi ^2\approx 8.5\) (\(\Delta \chi ^2\approx 9.5\)).     

Temporal Distributional Limit Theorems for Dynamical Systems

Suppose \(\{T^t\}\) is a Borel flow on a complete separable metric space X, \(f:X\rightarrow \mathbb R\) is Borel, and \(x\in X\). A temporal distributional limit theorem is a scaling limit for the distributions of the random variables \(X_T:=\int _0^t f(T^s x)ds\), where t is chosen randomly uniformly from [0, T], x is fixed, and \(T\rightarrow \infty \). We discuss such laws for irrational rotations, Anosov flows, and horocycle flows.     

Stochastic Averaging Principle for Spatial Birth-and-Death Evolutions in the Continuum

We study a spatial birth-and-death process on the phase space of locally finite configurations \({\varGamma }^+ \times {\varGamma }^-\) over \({\mathbb {R}}^d\). Dynamics is described by an non-equilibrium evolution of states obtained from the Fokker-Planck equation and associated with the Markov operator \(L^+(\gamma ^-) + \frac{1}{\varepsilon }L^-\), \(\varepsilon > 0\). Here \(L^-\) describes the environment process on \({\varGamma }^-\) and \(L^+(\gamma ^-)\) describes the system process on \({\varGamma }^+\), where \(\gamma ^-\) indicates that the corresponding birth-and-death rates depend on another locally finite configuration \(\gamma ^- \in {\varGamma }^-\). We prove that, for a certain class of birth-and-death rates, the corresponding Fokker-Planck equation is well-posed, i.e. there exists a unique evolution of states \(\mu _t^{\varepsilon }\) on \({\varGamma }^+ \times {\varGamma }^-\). Moreover, we give a sufficient condition such that the environment is ergodic with exponential rate. Let \(\mu _{\mathrm {inv}}\) be the invariant measure for the environment process on \({\varGamma }^-\). In the main part of this work we establish the stochastic averaging principle, i.e. we prove that the marginal of \(\mu _t^{\varepsilon }\) onto \({\varGamma }^+\) converges weakly to an evolution of states on \({\varGamma }^+\) associated with the averaged Markov birth-and-death operator \({\overline{L}} = \int _{{\varGamma }^-}L^+(\gamma ^-)d \mu _{\mathrm {inv}}(\gamma ^-)\).     

Synthesis and evaluation of bile acid amides of $$\alpha $$-cyanostilbenes as anticancer agents

A series of amino-substituted \(\alpha \)-cyanostilbene derivatives and their bile acid (cholic and deoxycholic acid) amides were designed and synthesized. A comparative study on the anticancer and antibacterial activity evaluation on the synthesized analogs was carried against the human osteosarcoma (HOS) cancer cell line, and two gram ?ve (E. coli and S. typhi) and two gram \(+\)ve (B. subtilis and S. aureus) bacterial strains. All the cholic acid \(\alpha \)-cyanostilbene amides showed an \(\hbox {IC}_{50}\) in the range 2–13 \(\upmu \hbox {M}\) against human osteosarcoma cells (HOS) with the most active analog (6g) possessing an \(\hbox {IC}_{50}\) of \(2\,\upmu \hbox {M}\). One of the amino-substituted \(\alpha \)-cyanostilbene, 4e, was found to possess an \(\hbox {IC}_{50}\) of \(3\,\upmu \hbox {M}\). An increase in the number of cells at the sub-\(\hbox {G}_{1}\) phase of the cell was observed in the in vitro cell cycle analysis of two most active compounds in the series (4e, 6g) suggesting a clear indication toward induction of apoptotic cascade. With respect to antibacterial screening, amino-substituted \(\alpha \)-cyanostilbenes were found to be more active than their corresponding bile acid amides. The synthesized compounds were also subjected to in silico study to predict their physiochemical properties and drug-likeness score.     

Asymptotic behavior of the Schrödinger–Debye system with refractive index of quadratic wave amplitude

We obtain local well-posedness for the one-dimensional Schrödinger–Debye interactions in nonlinear optics in the spaces \(L^2\times L^p,\; 1\le p < \infty \). When \(p=1\) we show that the local solutions extend globally. In the focusing regime, we consider a family of solutions \(\{(u_{\tau }, v_{\tau })\}_{\tau >0}\) in \( H^1\times H^1\) associated to an initial data family \(\{(u_{\tau _0},v_{\tau _0})\}_{\tau >0}\) uniformly bounded in \(H^1\times L^2\), where \(\tau \) is a small response time parameter. We prove that \(\left( u_{\tau }, v_{\tau }\right) \) converges to \(\left( u, -|u|^2\right) \) in the space \(L^{\infty }_{[0, T]}L^2_x\times L^1_{[0, T]}L^2_x\) whenever \(u_{\tau _0}\) converges to \(u_0\) in \(H^1\) as long as \(\tau \) tends to 0, where u is the solution of the one-dimensional cubic nonlinear Schrödinger equation with the initial data \(u_0\). The convergence of \(v_{\tau }\) for \(-|u|^2\) in the space \(L^{\infty }_{[0, T]}L^2_x\) is shown under compatibility conditions of the initial data. For non-compatible data, we prove convergence except for a corrector term which looks like an initial layer phenomenon.     

Isospin analysis of charmless <Emphasis Type="Italic">B</Emphasis>-meson decays

We discuss the determination of the CKM angle \(\alpha \) using the non-leptonic two-body decays \(B\rightarrow \pi \pi \), \(B\rightarrow \rho \rho \) and \(B\rightarrow \rho \pi \) using the latest data available. We illustrate the methods used in each case and extract the corresponding value of \(\alpha \). Combining all these elements, we obtain the determination \(\alpha _\mathrm{dir}={({86.2}_{-4.0}^{+4.4} \cup {178.4}_{-5.1}^{+3.9})}^{\circ }\). We assess the uncertainties associated to the breakdown of the isospin hypothesis and the choice of the statistical framework in detail. We also determine the hadronic amplitudes (tree and penguin) describing the QCD dynamics involved in these decays, briefly comparing our results with theoretical expectations. For each observable of interest in the \(B\rightarrow \pi \pi \), \(B\rightarrow \rho \rho \) and \(B\rightarrow \rho \pi \) systems, we perform an indirect determination based on the constraints from all the other observables available and we discuss the compatibility between indirect and direct determinations. Finally, we review the impact of future improved measurements on the determination of \(\alpha \).     

Synthesis,in vitro $$\alpha $$-glucosidase inhibitory activity,and in silico study of ( E)-thiosemicarbazones and ( E)-2-(2-(arylmethylene)hydrazinyl)-4-arylthiazole derivatives

This study is focused on the identification of thiazole-based inhibitors for the \(\alpha \)-glucosidase enzyme. For that purpose, (E)-2-(2-(arylmethylene)hydrazinyl)-4-arylthiazole derivatives were synthesized in two steps and characterized by various spectroscopic techniques. All derivatives and intermediates were evaluated for their in vitro \(\alpha \)-glucosidase inhibitory activity. Thiosemicarbazones 20 and 35, and cyclized thiazole derivatives 2, 5–11, 13, 15, 21–24, 27–31, and 36–37 showed significant inhibitory potential in the range of \(\hbox {IC}_{50}=6.2\pm 0.19\)–\(43.6\pm 0.23~\upmu \hbox {M}\) as compared to standard acarbose (\(\hbox {IC}_{50}=37.7\pm 0.19~\upmu \hbox {M}\)). A molecular modeling study was carried out to understand the binding interactions of compounds with the active site of enzyme.     

Synthesis of substituted 2<Emphasis Type="Italic">H</Emphasis>-chromenes by a three-component reaction as potential antioxidants

A series of alkoxy-substituted 2H-chromenes were synthesized by a one-pot three-component reaction using salicylaldehydes, acetyl acetone and alcohol as reactant and medium with tetra-n-butylammonium fluoride (TBAF) as catalyst. Simple reaction conditions, short reaction time and overall good yield of products make this synthetic strategy an efficient one to synthesize 2H-chromene molecules. All the synthesized compounds were evaluated for antioxidant activities. Among all the new compounds, 5j and 5k showed good inhibition \((70.41\, \pm \, 0.14\) and \(64.71\, \pm \, 1.02\%\)) at 100 \(\upmu \hbox {g/mL}\) concentrations.