Synthesis of halogen derivatives of 9-arylamino-1,2,3,4-tetrahydroacridines

A method has been proposed for obtaining halogen-substituted 9-arylamino-1,2,3,4-tetrahydroacridines from the anilides of the corresponding cyclohexylideneanthranilic acids.Translated from Khimiya Geterotsiklicheskikh Soedinenii, Vol. 6,No. 7, pp. 974–976, July, 1970.     

Electroneutral halogen benzene-cyclopentadienyl derivatives of iron

The preparation and properties of electroneutral complexes, HalC₆H₅FeC₅H₅ (Hal = Cl, F) and their dimers, [HalC₆H₅FeC₅H₅]₂, are described. Mass spectra of these compounds are discussed.The analysis of the ¹H and ¹⁹F NMR spectra of [HalC₆H₅FeC₅H₅]₂ has shown that these compounds are mixtures of syn- and anti-isomers.The reactivity of electroneutral HalC₆H₅FeC₅H₅ complexes and their dimers in nucleophilic substitution reactions has been studied and it has been shown that these compounds are inert as far as these reactions are concerned.     

Guanamine halogen derivatives with fluoroalkyl groups

A study is made of chlorination and bromination of 4, 6-diamino-s-triazines, with the following fluoro groups at position 2: CF₃, CF₂H, CFH₂, CFClH, CClF₂, and CFCl₂. The reactions were carried out at 5–10° and with excess water (15–20 fold). A reaction mechanism is based on intermediate formation of hypochlorous and hypobromous acids, which then react with the amino group. It is shown that the hydrogen atoms are replaced stepwise. In all cases bromination is slower than chlorination, and the N-bromo-substituted compounds less stable than the corresponding chlorine ones. Free hydrogens in the fluoroalkyl radicals are substituted last of all.     

Reaction of polynitroalkane salts with halogen derivatives of antimony

Conclusions In the reaction of trinitromethane and 1,1-dinitromethane salts with Ph₂SbCl,-polynitroalkylstibines are formed, irrespective of the nature of the cation (Ag⁺ or K⁺), i.e., the reaction proceeds at the-C atom of polynitrocarbanion. In reactions with Ph₄SbBr, tetraphenylstibonium salts of polynitroalkanes are formed.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khmicheskaya, No. 2, pp. 439–442, February, 1985.     

Thermal degradation of halogen derivatives of syndiotactic 1,2-polybutadiene

Thermal degradation of halogen derivatives of syndiotactic 1,2-polybutadiene, differing in the kind of the halogen, its content in the polymeric product, and its position in the monomeric unit, was studied by thermal gravimetric analysis. Comparative evaluation of the heat resistance of the halogenated polymers under consideration was made.     

Determination of some halogen osmium-carbonyl derivatives using ion-selective electrodes

Summary The concentrations of certain halogen derivatives of osmium carbonyls were determined potentiometrically by using a silver ion-selective electrode based potentiometric titration technique. In case of the series Os₃(CO)₁₂X₂, X= Cl, Br, I, inflections in the titration curves were at volumes of AgNO₃ corresponding to one halide ion. In contrast, the series Os₃(CO)₁₀X₂ gave inflections equivalent to two X^– ions. The concentrations of trans-Cl₂Os(CO)₄ as well as ClSnPh₃ were also determined by this technique. Standard deviations were in the range of 0.1%–0.37%, recoveries between 98% and 99.7%.

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Bestimmung einiger Halogenosmiumcarbonylverbindungen mit Hilfe von ionenselektiven Elektroden

     

Liquid crystalline behaviour of thienyl-enaminoketone derivatives containing halogen atoms

New homologous series containing a thienyl-enaminoketone-phenyl (TEP) core substituted by a halogen atom have been synthesized. It is shown that the stability of the orthogonal phases decreases with the decreasing electron-accepting properties of the halogen atom. Generally the materials studied form orthogonal smectic phases, but in additional, tilted smectic phases are observed in iodine-substituted series as well as for two homologues containing bromine in the thienyl ring. For comparison, a homologous series containing a terminal cyano group was also studied.     

Synthesis and properties of furan derivatives 2. Role of the halogen in RMgX in reactions with alkoxytetrahydrofurans

Heating 2-methoxytetrahydrofuran with ethylmagnesium bromide in benzene at reflux leads to the formation of 2-ethoxytetrahydrofuran and slight amounts of 4-methoxy-1-hexanol. Under analogous conditions, 2-ethoxytetrahydrofuran is quantitatively cleaved by methylmagnesium iodide to give 4-ethoxy-1-pentanol.For Communication 1, see [1]Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 592–594, May, 1992.     

Kinetics and mechanism of nucleophilic halogen exchange in furan derivatives

Studies are made of the reaction of 5-bromofurfurylidenaniline with aromatic amines (reaction 1), of the disproportionation of 5-bromofurfurylidenaniline (reaction 2), and of the reaction of 5-bromofurfurylidenaniline and 5-bromofurfural with saturated secondary amines (reaction 3). It is shown that these reactions are of the autocatalytic type (the catalyst being a reaction product, the hydrobromide of the amine), that addition of acid accelerates them, while they are retarded by addition of alkali. The hypothesis is advanced that in these reactions the active form of the substrate is the salt containing the fragment. The latter arises by protonation of the Schiff's base (reactions 1 and 2), or by quaternization of aminoacetals (which are products formed by addition of a secondary amine across the (double) bonds in through the action of the hydrohalide salt of the amine (reaction 3).     

卤代查尔酮氨基硫脲席夫碱的合成及生物活性研究

本文合成了一系列卤代查尔酮及其氨基硫脲席夫碱,并考察了所合成化合物的酪氨酸酶抑制活性及抗氧化活性。结果表明,部分化合物具有较好的酪氨酸酶抑制活性,其中3个化合物的抑制活性强于阳性对照曲酸,4-溴代查尔酮氨基硫脲席夫碱(化合物9)表现出最好的抑制活性,其IC50值为2.02μmol/L;部分化合物还具有一定的抗氧化活性。抑制机理研究表明,化合物9属于不可逆抑制剂。优选化合物9进行了分子对接探讨,初步构效关系分析为进一步研究具有酪氨酸酶抑制活性的类似化合物提供了参考。     

Reactions of 5,6-diamino-1,3-dimethyluracil with halogen derivatives of chalcones

The reaction of 5,6-diamino-1,3-dimethyluracil with 1,3-diaryl-2,3-dibromopropan-1-ones gave -(5-amino-6-imino-1,3-dimethyluracil)chalcones, and conditions for their cyclocondensation to pyrimidinodiazepines were found. For substantiation of the reaction mechanism, the reaction of the diamine with other halogen derivatives of chalcones was studied. The IR, UV, and mass spectra of the synthesized compounds and their condensation products are discussed.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 947–954, July, 1992.     

A study of the electronic spectrum of halogen derivatives of ethylene

The spectra of tetrachloroethylene, monofluoroethylene, gem-, cis- and trans-difluoroethylene and trifluoroethylene were studied in the region 150–250 nm in the gas, solid and Kr matrix. The valence character of the π å π^* transition in the various compounds was verified and the Rydberg transitions were identified. The lowest energy band in the fluoroethylene was found to be a Rydberg transition. The vibronic structure of the π å π^* transition in tetrachloroethylene indicates that the excited state geometry is planar. The existence of a π å σ^* transition at lower energy than the π å π^* transition was verified for cis-difluoroethylene and trifluoroethylene.