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1.
《Journal of heterocyclic chemistry》2017,54(4):2155-2196
Lawsone (2‐hydroxynaphthalene‐1,4‐dione ) is a natural product which shows significant biological activity. Lawsone has been found as a component of many dyes as well as a constituent of medicinal herbal treatments. So, this review aimed to document the publications concerning the synthesis and chemical reactivity and reactions of lawsone reported by research groups. 相似文献
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Mohammad Navid SoltaniRad Ali Khalafi‐Nezhad Somayeh Babamohammadi Somayeh Behrouz 《Helvetica chimica acta》2010,93(12):2454-2466
A convenient and efficient method for a one‐pot conversion of N‐alkylisatins to N‐alkylisatin O‐alkyloximes 7a – 7n as potential chemotherapeutic agents is described (Scheme) (isatin=1H‐indole‐2,3‐dione). In this method, the microwave‐assisted three‐component reaction of N‐alkylisatins 8 , hydroxylamine hydrochloride, and diverse alkyl halides in the presence of K2CO3 and Bu4NBr furnishes the corresponding N‐alkylisatin O‐alkyloximes under solvent‐free condition in short times (2–10 min) and good to excellent yields (62–83%). The O‐alkylation of in situ generated isatin oximes with alkyl halides was achieved regioselectively, and (Z)‐O‐alkyloximes were produced dominantly. PM3 Semi‐empirical quantum‐mechanic calculations were performed to rationalize the evidences, and the calculations indicated a lower heat of formation for the (Z)‐O‐alkyloximes. 相似文献
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An Efficient Synthesis of Spiro‐oxindole Derivatives by Three‐Component Reactions in Water 下载免费PDF全文
An efficient synthesis of (3S)‐1,1′,2,2′,3′,4′,6′,7′‐octahydro‐9′‐nitro‐2,6′‐dioxospiro[3H‐indole‐3,8′‐[8H]pyrido[1,2‐a]pyrimidine]‐7′‐carbonitrile is achieved via a three‐component reaction of isatin, ethyl cyanoacetate, and 1,2,3,4,5,6‐hexahydro‐2‐(nitromethylidene)pyrimidine. The present method does not involve any hazardous organic solvents or catalysts. Also the synthesis of ethyl 6′‐amino‐1,1′,2,2′,3′,4′‐hexahydro‐9′‐nitro‐2‐oxospiro[3H‐indole‐3,8′‐[8H]pyrido[1,2‐a]pyrimidine]‐7′‐carboxylates in high yields, at reflux, using a catalytic amount of piperidine, is described. The structures were confirmed spectroscopically (IR, 1H‐ and 13C‐NMR, and EI‐MS data) and by elemental analyses. A plausible mechanism for this reaction is proposed (Scheme 2). 相似文献
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A novel three‐component reaction of o‐bromobenzaldehyde, terminal alkynes and tert‐butyl amine has been established, which proceeded smoothly to give 3‐substituted isoquinolines in good yields in the presence of palladium/copper catalysts under microwave irradiation. 相似文献
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Microwave‐Assisted Three‐Component Reactions Leading to Pyrano‐Fused Pyrazolo[3,4‐b]pyridines 下载免费PDF全文
Bi‐Hui Xu Man‐Su Tu Yin‐Ping Liu Bo Jiang Xing‐Hang Wang Shu‐Jiang Tu 《Journal of heterocyclic chemistry》2014,51(6):1591-1594
A series of pyrano‐fused pyrazolo[3,4‐b]pyridine derivatives with an aryl group presenting the 2‐position of the pyridine nucleus have been synthesized by microwave‐assisted three‐component reactions of aldehydes, tetrahydropyran‐4‐one, and 3‐methyl‐1‐phenyl‐1H‐pyrazol‐5‐amine in HOAc. This method is very efficient because of short reaction times and easy work‐up, and it provides an efficient and promising synthetic strategy for the construction of the tricyclic pyrano‐fused pyrazolo[3,4‐b]pyridine skeleton. 相似文献
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A New Approach to the Synthesis of Poly‐Functionalized Pyrano[2,3‐d]Pyrimidines Derivatives via Microwave‐Assisted Multi‐Component Reactions without Catalyst 下载免费PDF全文
Runhong Jia Juhua Peng Bo Jiang Junyong Zhang Shu‐Jiang Tu 《Journal of heterocyclic chemistry》2015,52(1):193-196
A facile microwave‐assisted synthesis of pyrano[2,3‐d]pyrimidines derivatives is accomplished via reactions of 4‐arylmethylene‐2‐phenyloxazol‐5(4H)‐ones with pyrimidine‐4,6‐diol in ethylene glycol. The reaction is simple to perform and occurs under mild conditions with broad scope of applicability. 相似文献
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Danqing Zheng Armido Studer 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(44):15950-15954
An enantioselective three‐component radical reaction of quinolines or pyridines with enamides and α‐bromo carbonyl compounds by dual photoredox and chiral Brønsted acid catalysis is presented. A range of valuable chiral γ‐amino‐acid derivatives are accessible in high chemo‐, regio‐, and enantioselectivity from simple, readily available starting materials under mild reaction conditions. Using the same strategy, the asymmetric synthesis of 1,2‐diamine derivatives is also reported. 相似文献
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Faramarz Rostami‐Charati Zinatossadat Hossaini Ebrahim Gharaee Mohammad A. Khalilzadeh 《Journal of heterocyclic chemistry》2013,50(Z1):E174-E177
A one‐pot synthesis of oxazine derivatives via reaction between activated acetylenic compounds, benzoyl cyanide, and N‐nucleophiles in water as the solvent is described?. 相似文献
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A novel three‐component reaction involving 2‐methylbenzothiazole or 2,5‐dimethylbenzothiazole, acetylenic esters and 1,3‐dicarbonyl compounds such as (1,3‐dimethylbarbituric acid or 1,3‐indanedione) leading to the synthesis of spiro pyrrolobenzothiazole derivatives. The reactions proceeded smoothly at room temperature without using any catalyst. This method is very useful to functionalize benzothiazole derivatives in a one‐pot operation. The structures of the synthesized compounds have been characterized by spectral studies. 相似文献
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Emre Menteşe Musa Özil Şengül Alpay Karaoğlu Bahittin Kahveci 《Journal of heterocyclic chemistry》2013,50(2):386-390
A growing body of literature has shown the effectiveness of using microwaves in chemical reactions. The aim of this study is to demonstrate a rapid and highly efficient synthesis of some new triazol‐3‐ones via microwave heating using a monomode microwave. Compared with the thermal process, the microwave heating induces a dramatic reduction of the reaction time and improvement of the yields. In this study, rapid N‐benzylation and N‐acetylation of triazol‐3‐ones were achieved by microwave irradiation method for the first time. The newly synthesized compounds showed moderate antimicrobial activity against the standard bacterial and fungal organisms tested. 相似文献
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《Journal of heterocyclic chemistry》2018,55(1):209-213
An easy and effective procedure for one‐pot three components coupling of 4‐hydroxycumarin, isothiocyanates, and isocyanides in water by employing magnetically recoverable Fe3O4 nanoparticles is described. Variety of chromene were produced a derivatives in high yields by using of this procedure. The catalyst can be recovered and recycled without a considerable decrease in the catalytic activity. 相似文献
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A series of new dispiropyrrolidine derivatives were synthesized via the three‐component 1,3‐dipolar cycloaddition reaction of azomethine ylides generated in situ by the decarboxylative condensation of acenaphthenequinone and sarcosine or l ‐thioproline with 5‐benzylidene‐1,3‐dimethylpyrimidine‐2,4,6‐trione. The structures of the products were identified by IR, 1H‐NMR, and HRMS spectra. 相似文献
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An environmentally benign and efficient method has been developed for the synthesis of functionalized tetrahydroindole derivatives in aqueous media under catalyst‐free conditions, by simply combining a phenylglyoxal monohydrate, an enaminone, and a barbituric acid. The advantages of this method are that it is catalyst free, has an easy workup, provides good yields, and uses water as solvent, which make this procedure facile and practical. 相似文献
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Synthesis of 2‐Arylbenzothiazoles by Copper‐Catalyzed One‐Pot Three‐Component Reactions in Water 下载免费PDF全文
Hualong Xu Chun Luo Zhengkai Li Haifeng Xiang Xiangge Zhou 《Journal of heterocyclic chemistry》2016,53(4):1207-1213
Copper‐catalyzed three‐component reactions of 2‐iodoanilines, benzylamines, and sulfur powder are reported to afford benzothiazoles in a simple one‐pot procedure by using water as solvent. A variety of 2‐arylbenzothiazoles were obtained in moderate to good yields up to 88%. 相似文献
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Pei Chen Yan Li Xinbing Chen Zhongwei An Yiwei Xu Xiaojun He 《Journal of heterocyclic chemistry》2014,51(4):1210-1214
A convenient one‐pot microwave‐assisted synthesis of Benzopyrano[2,3‐c]pyrazol‐3‐one derivatives was developed, where Knoevenagel condensation and hydrazinolysis reactions were continuously performed under microwave irradiation without separation and purification of the intermediates until the last cyclocondensation reaction except the substrates addition. The one‐pot procedure exhibited shorter reaction times and higher yields (25–55%) of the objects than the conventional heating method. 相似文献
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Shailesh Thakrar Abhay Bavishi Ashish Radadiya Shrey Parekh Dhairya Bhavsar Hardevsinh Vala Nilay Pandya Anamik Shah 《Journal of heterocyclic chemistry》2013,50(Z1):E73-E79
A new series of highly functionalized 1,5‐benzodiazepine derivatives 5a–x have been synthesized from 3‐[(1E)‐N‐(2‐aminophenyl) ethanimidoyl]‐4‐hydroxyl‐2H‐chromen‐2‐one 3a–c and pyrazole aldehyde 4a–h using catalytic amount of triflouro acetic acid under microwave irradiation. The main significant of the present procedure is shorter reaction time, easy work up procedure, and excellent yield with high purity. The structures of all the compounds were established on the basis of their IR, NMR, and mass spectral data and have been screened for their antimicrobial activity and antifungal activity. 相似文献
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Pyranoquinoline derivatives have been synthesized via three‐component reaction of 4‐hydroxy‐1‐methyl‐2(1H)‐quinolinone and dialkyl acetylenedicarboxylates in the presence of nucleophiles such as alkyl isocyanides and triphenylphosphine. 相似文献