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1.
I. V. Ukrainets I. A. Tugaibei N. L. Bereznyakova V. N. Kravchenko A. V. Turov 《Chemistry of Heterocyclic Compounds》2008,44(5):565-575
Alkyl-, arylalkyl-, and arylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid were prepared with a view
to establishing a structure-biological activity relationship. A comparative analysis has been made of their diuretic properties
and those of the structurally similar 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 718–729, May, 2008. 相似文献
2.
With urea 1,5-diaryl-3-hydroxy-4-methylsulfonyl-3-pyrrolin-2-ones form the 3-amino derivatives of pyrrolones. In reactions
with hydrazine hydrate and ethylenediamine the corresponding salts are formed. With ethylenediamine at 180–185°C the double
salt of 3-hydroxy-4-methylsulfonyl-1,5-diphenyl-3-pyrrolin-2-one forms N,N′-di(4-methylsulfonyl-1,5-diphenyl-3-pyrrolin-2-on-3-yl)-ethylenediamine.
The reaction with o-phenylenediamine gives 2,3-diaryl-4-methylsulfonylpyrrolo-[2,3-b]quinoxalines.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, 1631–1636, November, 2007. 相似文献
3.
Condensation of Schiff"s bases (prepared from 2-hydroxy- or 2-hydroxy-5-methylacetophenones and primary amines) with ethyl polyfluoroalkanoates in the presence of LiH in THF affords 3-alkylamino-3-(2-hydroxyaryl)-1-polyfluoroalkylprop-2-en-1-ones, which undergo cyclization in acidic media into 2-polyfluoroalkyl-4H-chromen-4-iminium salts. When neutralized with aqueous ammonia, the latter give 2-polyfluoroalkyl-4H-chromen-4-imines in high yields. 相似文献
4.
I. V. Ukrainets N. L. Bereznyakova I. A. Turaibei 《Chemistry of Heterocyclic Compounds》2008,44(1):50-63
Dialkylaminoalkylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids have been obtained as potential antiviral
agents. The special features of the spatial structure of one example of the synthesized compounds have been studied. Results
are given of the investigation of cytotoxicity and antiviral activity in relation to type 1 herpes virus and coronavirus.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 61–77, January, 2008. 相似文献
5.
I. V. Ukrainets V. V. Kravtsova A. A. Tkach G. Sim 《Chemistry of Heterocyclic Compounds》2008,44(2):173-177
Treatment of 1R-4-chloro-3-ethoxycarbonyl-2-oxo-1,2-dihydroquinolines with p-toluenesulfonylhydrazide in refluxing ethanol
and in the presence of triethylamine gives the 3-hydroxy-5R-1,5-dihydropyrazolo[4,3-c]quinolin-4-ones. The possible mechanism
of formation, features of the steric structure of the synthesized compounds, and their NMR and mass spectra are discussed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 233–238, February, 2008. 相似文献
6.
2-Polyfluoroalkylchromene-4(4H)-thiones, synthesized from 2-polyfluoroalkylchromones and P2S5, react with aniline, phenylhydrazines, and hydroxylamine at the C(4) atom and afford corresponding anils, phenylhydrazones, and oximes of chromones. On heating in alcohol in the presence of concentrated HCl, chromone phenylhydrazones and oximes undergo ring closure to form 3-(2-hydroxyaryl)-1-phenyl-5-polyfluoroalkylpyrazoles and 5-hydroxy-3-(2-hydroxyaryl)-5-polyfluoroalkyl-Δ2-isoxazolines.__________Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 2188–2195, October, 2004. 相似文献
7.
I. V. Ukrainets N. L. Bereznyakova G. P. Petyunin I. A. Tugaibei V. B. Rybakov V. V. Chernyshev A. V. Turov 《Chemistry of Heterocyclic Compounds》2007,43(6):729-739
An improved method for the preparation and purification of ethyl 2-hydroxy-4-oxo-4H-pyrido[1,2-a]-pyrimidine-3-carboxylates
is proposed. According to 1H and 13C NMR spectroscopic data the synthesized compounds exist in DMSO solution in the 2-hydroxy-4-oxo form while in the crystal
(at least for the case of the unsubstituted derivative) X-ray analysis shows that it occurs in the bipolar 2,4-dioxo form.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 864–876, June, 2007. 相似文献
8.
A reverse phase HPLC method was developed and validated for the simultaneous determination of 2-hydroxy-4-methoxybenzaldehyde
and 2-hydroxy-4-methoxybenzoic acid in the root extracts of Hemidesmus indicus. A comprehensive validation of the method including sensitivity, linearity, reproducibility, accuracy, limit of detection
(LOD) and limit of quantification (LOQ) was conducted using the optimized chromatographic conditions. The method was found
to be linear (r > 0.998) in the range of 5–350 μg mL−1 for 2-hydroxy-4-methoxybenzaldehyde and for 2-hydroxy-4-methoxybenzoic acid (r > 0.999) in the range 10–300 μg mL−1. The method was found to be precise with inter-day precision values (% RSD) in the ranges of 0.61–1.76% for 2-hydroxy-4-methoxybenzaldehyde
and 1.3–2.8% for 2-hydroxy-4-ethoxybenzoic acid while intra-day precisions (% RSD) of two analytes were in the range of 0.41–1.07
and 0.95–2.5%. The limits of detection (LODs) for 2-hydroxy-4-methoxybenzaldehyde and 2-hydroxy-4-methoxybenzoic acid were
0.84 and 2.34 μg mL−1. The described method was fast, sensitive and reproducible, and thus well suited for routine analysis of these two compounds
from root extracts of H. indicus and other plants. 相似文献
9.
I. V. Ukrainets L. V. Sidorenko O. V. Gorokhova S. V. Slobodzyan 《Chemistry of Heterocyclic Compounds》2007,43(1):63-66
The reaction of 2-ethoxycarbonylmethyl-4H-3,1-benzoxazin-4-one with malononitrile in dry pyridine leads to 1-hydroxy-3,6-dioxo-4,6-dihydro-3H-pyrimido[1,2-a]quinoline-5-carbonitrile.
Acetoacetic and cyanoacetic esters under analogous conditions form anilides of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic
acid while diethyl malonate gives N,N′-di-2-carboxyanilides of malonic acid.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 75–79, January, 2007. 相似文献
10.
Ana I. R. N. A. Barros André F. R. Dias Artur M. S. Silva 《Monatshefte für Chemie / Chemical Monthly》2007,138(6):585-594
Summary. A one-pot synthesis of novel 2-arylquinolines and 2-aryl-4-hydroxyquinolines was developed from the intramolecular reductive
coupling reactions of 2-nitrochalcones and 3-hydroxy-1-phenyl-3-(2-nitrophenyl)-2-propen-1-ones. Depending on the reduction
method and on the presence of electron donating substituents on the A ring of 2-nitrochalcones one can modulate the formation
of 2-arylquinolines, their N-oxides, and of 2-aminochalcones. The reduction of 3-hydroxy-1-(2-hydroxyphenyl)-3-(2-nitrophenyl)-2-propen-1-ones with stannous
chloride in hydrochloric acid gave 2′-aminoflavones and with ammonium formate and Pd/C yielded 2-(2-hydroxyaryl)-4-hydroxyquinolines. 相似文献
11.
I. A. Kirilyuk D. A. Morozov Yu. S. Tabatchikova V. S. Medvedev A. V. Lebedev G. V. Romanenko T. V. Rybalova I. A. Grigor’ev 《Russian Chemical Bulletin》2008,57(7):1516-1533
The condensation of 3-hydroxyamino-3-methylbutan-2-one or 3-ethyl-3-hydroxyamino-pentan-2-one with aldehydes and ammonia afforded
a series of new 1-hydroxy-4-methyl-2,5-dihydroimidazoles, whose oxidation gave rise to the corresponding 5-methyl-4H-imidazole 3-oxides. The latter, like 1-hydroxy-4-methyl-2,5-dihydroimidazoles, react with PriONO in the presence of bases to form 4H-imidazole-5-carbaldoxime 3-oxides, which are transformed into 4H-imidazole-5-carbonitrile 3-oxides in the reaction with TsCl in the presence of Et3N. The by-products produced in different steps of the synthesis were isolated and characterized.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1487–1503, July, 2008. 相似文献
12.
A. A. Bogolyubov N. B. Chernysheva V. V. Nesterov M. Yu. Antipin V. V. Semenov 《Chemistry of Heterocyclic Compounds》2004,40(10):1305-1309
The dehydration of two 5,5-disubstituted 4-hydroxy-4-methyl-3-phenylaminooxazolidin-2-ones into the corresponding 4-methylene-3-phenylaminooxazolidin-2-ones has been carried out. The structure of the products was confirmed by X-ray diffraction analysis.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1512–1517, October, 2004. 相似文献
13.
I. V. Ukrainets L. V. Sidorenko O. V. Gorokhova S. V. Shishkina A. V. Turov 《Chemistry of Heterocyclic Compounds》2007,43(5):617-628
Bromination of N-allyl-substituted 4-hydroxy-2-quinolinones with molecular bromine in acetic acid or carbon tetrachloride
occurs with closing of a five membered oxazole ring to give 2-bromomethyl-5-oxo-1,2-dihydro-5H-oxazolo[3,2-a]quinoline.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 736–749, May, 2007. 相似文献
14.
L. V. Andriyankova S. A. Zhivet'ev A. G. Mal'kina M. A. Andriyankov A. V. Afonin B. A. Trofimov 《Chemistry of Heterocyclic Compounds》2002,38(8):974-980
The reaction of 2,3-dimercaptoquinoxaline with 3-phenyl-2-propynonitrile (~10 mass % KOH, 20-25°C, 5 h, dioxane) gave the S,S-diadduct (as with unsubstituted acetylene). 2,3-Dimercaptoquinoxaline reacted with 4-alkyl-4-hydroxy-2-alkynonitriles to give 2-cyanomethyl-2-(1-hydroxy-1-alkyl)-1,3-dioxolano[4,5-b]quinoxalines or 3-cyanomethylene-8-imino-2,2,6,6-tetramethyl-1,7-dioxa-4-thiaspiro[4.4]nonane. 相似文献
15.
Condensation of ethyl 2,4-dioxopentanoate with ethyl trifluoroacetate in the presence of NaOEt leads to ethyl 4-oxo-6-(trifluoromethyl)-4H-pyran-2-carboxylate, from which the corresponding acid and its amide, as well as 4-hydroxy-6-(trifluoromethyl)pyridine-2-carboxamide
were obtained.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 537–538, March, 2007. 相似文献
16.
A synthesis and study of the spatial structure of 3-acetyl-4-hydroxy-2-oxo-1,2-dihydroquinoline have been carried. 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic
acids [1-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)ethylidene]hydrazides were prepared from this compound by two routes. A
comparative analysis of the antitubercular properties of the synthesized compounds and of the closely structurally related
N,N′-di(1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)hydrazines has been performed.
*For Communication 151 see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 214–222, February, 2009. 相似文献
17.
S. G. Krivokolysko A. N. Chernega V. P. Litvinov 《Chemistry of Heterocyclic Compounds》2002,38(10):1269-1275
N-Methylmorpholinium 5-[2-cyanoethyl-1-(4-hydroxy-3-methoxyphenyl)-2-thiocarbamoyl]-2,2-dimethyl-6-oxo-1,3-dioxa-4-cyclohexen-4-olate was obtained from the reaction of 4-hydroxy-3-methoxybenzaldehyde with cyanothioacetamide and Meldrum's acid in the presence of N-methylmorpholine. The molecular and crystal structure of the title compound have been established and its alkylation has been studied. 相似文献
18.
Shubhangi C. Joshi Kunjbihari N. Trivedi 《Monatshefte für Chemie / Chemical Monthly》1992,123(6-7):557-564
Summary The Claisen rearrangement of 7-(3-phenyl-2-propenyloxy)-3-phenyl-(4H)-1-benzopyran-4-one (2 a) gave 7-hydroxy-8-(1-phenyl-2-propenyl)-3-phenyl-(4H)-1-benzopyran-4-one (3 a) and 2,3-dihydro-2,6-diphenyl-3-methyl-(7H)furo[2,3-h]-1-benzopyran-7-one (7 a). 2-Methyl-7-(3-phenyl-2-propenyloxy)-3-phenyl-(4H)-1-benzopyran-4-one (2 b) afforded4 b and7 b. 8-Methyl-7-(3-phenyl-2-propenyloxy)-3-phenyl-(4H)-1-benzopyran-4-one (12) gave only the alkali soluble product 7-hydroxy-8-methyl-6-(1-phenyl-2-propenyl)-3-phenyl-(4H)-1-benzopyran-4-one (13).3 a,4 b, and13 were further cyclized in acidic medium to9 a,10 b, and14 followed by dehydrogenation.This paper is dedicated to Dr. F. M. Dean, Department of Organic Chemistry, Robert Robinson Laboratories, University of Liverpool, Liverpool, U. K., on his retirement 相似文献
19.
Adam Jarmua Wojciech R. Rypniewski Krzysztof Felczak Wojciech Rode 《Structural chemistry》2005,16(5):541-549
The crystal and molecular structures of the 3′,5′-di-O-acetyl-N(4)-hydroxy-2′-deoxycytidine molecule and its 5-fluoro congener have been determined by X-ray single crystal diffraction. The 3′,5′-di-O-acetyl-N(4)-hydroxy-5-fluoro-2′-deoxycytidine molecule crystallizes in the space group C2 with the following unit cell parameters: a = 21.72 Å, b = 8.72 Å, c = 8.61 Å, and β = 90.42∘. 3′,5′-di-O-acetyl-N(4)-hydroxy-2′-deoxycytidine also belongs to the monoclinic space group C2 and the unit cell parameters are: a = 39.54 Å, b = 8.72 Å, c = 22.89 Å, and β = 95.26∘. The non-fluorine analogue demonstrates a rare example of crystal structure with five symmetry-independent molecules in the unit cell. All the molecules in both crystal structures have the sugar residue anti oriented with respect to the base, as well as have the N(4)-OH residue in cis conformation relatively to the N(3)-nitrogen atom. In addition to the molecular geometries from X-ray experiment, the optimized molecular geometries have been obtained with the use of theoretical ab initio calculations at the RHF/6-31G(d) level. The corresponding geometric parameters in the molecules of 3′,5′-di-O-acetyl-N(4)-hydroxy-2′-deoxycytidine and its 5-fluoro congener have been compared. The differences including the C(5)=C(6) bond shortening and C(4)—C(5)—C(6) angle widening in the fluorine analogue are discussed in this paper in relation to the molecular mechanism of enzyme, thymidylate synthase, inhibition by N(4)-hydroxy-2′-deoxycytidine monophosphate and its 5-fluoro congener. 相似文献
20.
E. O. Chukhadzhyan A. R. Gevorkyan El. O. Chukhadzhyan K. G. Shakhatuni F. S. Kinoyan G. A. Panosyan 《Chemistry of Heterocyclic Compounds》2004,40(1):29-36
The ability of the 4-hydroxy-2-butynyl group to participate as ,-unsaturated fragment in base-catalyzed intramolecular cyclization was established. 2,2-Dialkyl-4-hydroxymethylbenzo[f]isoindolinium and 2,2-dialkyl-4-hydroxymethylisoindolinium salts were obtained by the cyclization of dialkyl(4-hydroxy-2-butynyl)(3-phenylpropargyl)- or dialkyl(4-hydroxy-2-butynyl)(3-alkenylpropargyl)ammonium salts. 相似文献