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Two new isobutyltartrate monoesters,coelovirin A (1) and B(2),were isolated from the rhizomes of Coeloglossum viride (L.) Hartm. var. bracteatum (Willd.) Richter (Orchidaceae). Their structures were elucidated as (2R,3S)-2-isobutyltartrate-1-(4-β-D-glucopyranosyloxybenzyl) ester 1 and (2R,3S)-2-isobutyltartrate-4-(4-β-D-glucopranosyloxybenzyl) ester 2 on the basis of physical constants and spectroscopic methods including 2D NMR techniques. 相似文献
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Crataegus pinnatifida Bge.var.major N.E.Br. is widely distributed in the northeast part of China. It is used as a medicinal plant to improve digestion, remove retention of food, promote blood circulation and resolve blood stasis both in traditional and folk medicine 1. Preparations of Crataegus leaves improve the heart function, the coronary blood supply and arrhythmia2. Up to now, fifty flavonoids have been isolated from Crataegus3,4. In our previous paper, some new flavonoid glycosides we… 相似文献
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Two new compounds,oleanolic acid 28-O- β-D-glucopyranosyl-3-O-α-L-arabinopyranosyl-(1→3)-(6′-butyl ester)-β-D-glucuropyranoside 1,oleanolic acid 28-O-β-D-glucopyranosyl(1→6)-β-D-glucopyranoside 2 have been isolated from the roots of Hemsleya penxianensis var.gulinensis.Their structures were determined on the bases of the spectral and chemical evidences. 相似文献
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<正>One new triterpene saponin was isolated from Panaxjaponicus C.A.Meyer var major(Burk.) C.Y.Wu et K.M.Feng,and established as oleanolic acid 3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranosyl-6'-O-n-butyl ester]which showed moderate antitumor activities against the A2780 cells and OVCAR-3 cells.Its structure was established by means of spectral data, particularly NMR,including HSQC and HMBC techniques. 相似文献
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Bioguided Isolation and Antiproliferative Activity of Constituents from Smilax korthalsii A.D.C. Leaves 下载免费PDF全文
Abdulmumeen A. Hamid Olapeju O. Aiyelaagbe Arvind S. Negi Suaib Luqman Fatima Kaneez 《中国化学会会志》2016,63(7):562-571
Ethyl acetate extract of Smilax korthalsii A.D.C. leaves exhibited antiproliferative activity on leukaemia carcinoma K562, hepatic liver cancer cells WRL and colorectal carcinoma with IC50 of 125.20, 46.10 and 160.00 μM respectively. Isolation of the bioactive ethyl acetate extract of Smilax korthalsii A.D.C. leaves gave eight compounds; 3β‐hydroxyspirost‐5‐ene (diosgenin), 1 , β‐sitosterol, 2 , lup‐5,11,20‐trien‐23‐ol, 3 , uneicos‐9‐enoic acid, 4 , ethylheptadecan‐17‐oic‐9‐enoate, 5 , cis‐octadec‐9‐enoic acid, 6 , hexadec9‐enoic acid, 7 and 11‐methyltridec‐12‐en‐1‐ol, 8 . The isolated compounds were tested against four human cancer cell lines: leukaemia carcinoma, K‐562; hepatic liver cancer cells, WRL; colorectal carcinoma, COLO; and breast carcinoma, MCF‐7 using the MTT assay. Diosgenin 1 exhibited significant antiproliferative activity against all four cell lines (IC50; K562=6.25, WRL=14.34, COLO=38.00, MCF‐7=12.40 μM), while compounds 3, 6 and 7 inhibited the growth of K‐562 at 20, 50 and 100 μM concentrations with IC50 of 90.20, 75.92 and 50.72 μM respectively. Other isolated compounds also showed cytotoxic properties against K‐562, WRL and COLO, but showed low inhibition of MCF‐7. 相似文献