共查询到20条相似文献,搜索用时 62 毫秒
1.
2.
3.
4.
5.
以间苯二酚和3-甲氧基-4-羟基苯乙酸为原料,经"一锅法"制备了毛蕊异黄酮(3);3与溴代烷经取代反应合成了9个7-烷氧基毛蕊异黄酮衍生物(5a~5i),其中5a~5g和5i为新化合物,其结构经1H NMR,13C NMR和ESI-MS表征。采用MTT法考察了3和5a~5i对乳腺癌细胞(MCF-7),结肠癌细胞(SW480)和胰腺癌细胞(Hep G2)的抑制活性。结果表明,3'-羟基-4'-甲氧基-7-环戊氧基异黄酮(5e)抗肿瘤活性最好。在用药量为3.1μg·m L-1时,对MCF-7,SW480和Hep G2的抑制率分别为89.20%,77.33%和44.32%。 相似文献
6.
含全氟烷基磺酰基新型异黄酮化合物的合成 总被引:1,自引:0,他引:1
异黄酮类化合物广泛存在于植物中,是许多中草药的有效成分。美国食品和药物管理局将大豆列为能够真正降低患心脏病危险的少数食品之一,研究发现大豆防病作用的关键因素在于其中大量存在的各类黄酮类成分[1]。1993年Coward等[2]首次报道大豆异黄酮具有抵御癌细胞的作用,其后W ei 相似文献
7.
8.
10.
11.
12.
一锅法合成11-氨基十一酸的研究 总被引:3,自引:1,他引:3
探索了一锅法合成11-氨基十一酸的方法,与分步合成法相比,一锅法具有操作简便、反应条件温和、无需分离中间体、产率较高等特点。并讨论了温度、反应时间、氨比等对一锅法合成产率的影响。 相似文献
13.
14.
《合成通讯》2013,43(18):3123-3130
Abstract Aryldiazepinothiophenones 2 were prepared from the reaction of o-phenylenediamines with acetone in the presence of 2-mercaptopropionic acid. Fused thiazolobenzodiazepines 3 along with fused thiazolobenzimidazoles 4 and 1,5-benzodiazepines 5 were obtained as by-products. The benzodiazepinothiophenone 2a and the benzodiazepine 5a were also isolated from the reaction of o-phenylenediamine with phorone. 相似文献
15.
16.
1,3,4-二唑类化合物具有广泛的生物生理活性,如杀菌[1]、除草[2]、杀虫[3]和消炎[4]等,而2,5-二芳基-1,3,4-二唑类化合物一般具有昆虫生长调节活性,1980年美国Dow公司报道了2,5-双(2,4-二氯苯基)-1,3,4-二... 相似文献
17.
18.
漆原钴法制备四羰基钴钠及羰基化反应 总被引:4,自引:0,他引:4
谈基钻的传统制备方法“提在高温高压下,由合成气与钻盐反应制备出CO。(CO)s,再经某些化学处理方法制备Na[CO(CO)。I,但其反应条件苛刻,操作手续繁杂,成本高,不利于大量推广应用.制备四谈基钻盐方法,还有KCN转化法[”,NaBH。还原法‘’‘等,但各种方法均有一定缺点.我们报道了Ranev-Ni催化剂催化合成Na[Co(CO)。」的新方法*”‘.此方法收率高,反应条件温和,具有较好的应用前景,但仍存在Ni、CO分离的问题.进一步改进催化剂、降低成本、高效地合成N迁C。(CO)。」仍是解决问题的关键.为此,我们探讨… 相似文献
19.
以廉价底物苯甲醛、 丙酮酸和NH4Cl为原料, 通过级联乙醛羟酸合成酶(ASAHⅠ)催化缩合反应和胺脱氢酶(BbAmDH)催化还原胺化反应, 构建了去甲基麻黄素的生物合成新途径. 通过优化分步法和一锅法的反应条件, 使苯甲醛转化率分别达到99%和83%. 采用一锅法, 利用底物补料策略, 有效解除了ASAHI的底物和产物抑制作用, 批次反应的苯甲醛浓度从40 mmol/L提高到100 mmol/L, 苯甲醛转化率从83%提高到90%, 苯甲醛的时空转化率提高了2.7倍. 相似文献
20.
ZuminQiu YunbingHe DianmoZheng FufangLiu 《天然气化学杂志》2005,14(1):40-46
The influences of some factors on the yield of phenylacetic acid in the carbonylation of benzyl chloride were studied in this paper. These factors included the variety and content of catalyst, and that of solvent, way of material feeding, reaction temperature, sodium hydrate concentration, triphenylphosphine content, presence of surfactant, the ratio of organic phase volume to aqueous phase volume etc. The optimum reaction conditions were found to be: with a one-time pour of 0.15g Pd(PPh3)2Cl2, 0.24g PPh3, 75ml NaOH of 3.5mol/L, 20ml benzyl chloride and 55ml n-butyl alcohol, and the reaction was carried out at 50℃ for about 3 hours. The as-obtained yield of phenylacetic acid was as high as 97.6%. In addition, the influences of the presence of phenylacetic acid and air in the reaction system were also studied. The results showed that the presence of air in the system and the entrainment of phenylacetic acid in the circulating organic phase had great influence on the reaction rate, the stability and performance of catalyst and the yield of phenylacetic acid. 相似文献