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1.
标题化合物可在微波辐射下以良好的产率经一锅法合成,为2-氨基-4H-吡哺类化合物的制备提供了一种快速便捷的有效方法。 相似文献
2.
A. V. Samet A. M. Shestopalov M. I. Struchkova V. V. Semenov V. N. Nesterov Yu. T. Struchkov 《Russian Chemical Bulletin》1996,45(8):1945-1951
Previously unknown 5-azolylpyrans were obtained by reactions ofN-acetonyl- andN-phenacylimidazoles, -triazoles, and -tetrazoles with arylmethylenemalononitriles. The structure of 2-amino-3-cyano-6-methyl-5-(5-nitrotetrazol-2-yl)-4-phenyl-4H-pyran was established by X-ray structural analysis.Deceased.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 2050–2055, August, 1996. 相似文献
3.
A. D. Dyachenko S. M. Desenko V. D. Dyachenko 《Chemistry of Heterocyclic Compounds》2004,40(8):1017-1023
Treatment of monothiomalonodiamide with cyclohexylidenemalononitrile or cyclohexylidenecyanoacetic ester in the presence of sodium ethylate gave 6-amino-3-carbamoyl-5-cyano-3,4-dihydrospirocyclohexane-4-pyridine-2-thiol and 5-cyano-3-thiocarbamoyl-4-spirocyclohexanepiperidine-2,6-dione. Their alkylation and hydrolysis have been studied. 相似文献
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6.
V. A. Dorokhov A. V. Komkov A. M. Sakharo V. S. Bogdanov 《Russian Chemical Bulletin》1996,45(1):168-170
A method hxsynthesizing 3-acetyl-2-amino-4-pyyridone has been suggested. The synthesis involves the condensation of dimethylformamide dimethylacetal at the NH2 group of diphenylboron chelate diacetylketene aminal followed by its intramolecular cyclization under the action of NaOMe in MeOH.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 177–179. January, 1996. 相似文献
7.
Three-component condensation of benzooxazol-2-yl-, benzothiazol-2-yl-, and 5-ethoxycarbonyl-4-methyl-1,3-thiazol-2-ylguanidines
with orthoesters and aroylacetonitriles afforded 4-aryl-5-cyano-2-hetarylaminopyrimidines.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1049–1050, June, 2006. 相似文献
8.
Yong Sun Li-Ping Gao Zhi-Qiang Guo Ming-Wu Ding 《Phosphorus, sulfur, and silicon and the related elements》2013,188(9):2109-2116
2-alkylthio-3-alkyl-5-arylmethylidene-4H-imidazol-4-ones were synthesized by the S-alkylation and N-alkylation of 2-thioxo-5-arylmethylidene-4-imidazolidinones, which were obtained via a tandem aza-Wittig reaction of vinyliminophosphoranes, carbon disulfide, and excess ammonium hydroxide (28% NH3 in water). 相似文献
9.
二氨基-3-硝基吡啶和2_氨基-5-硝基吡啶的EI—MS质谱图接近,单纯通过Ⅱ-MS质谱图较难区分这两种异构体,作者以甲烷为反应气对2-氨基-3-硝基吡啶和2-氨基-5-硝基吡啶进行化学电离,并利用离子阱质谱的串联质谱技术在离子阱内以He作碰撞气进行碰撞诱导裂解,所得的CI—MS—MS质谱图表明,两者之间存在明显的差别,可用于2-氨基-3-硝基吡啶和2-氨基一5一硝基吡啶的鉴别。 相似文献
10.
A. V. Varlamov T. N. Borisova Boniface Nsabimana A. I. Chernyshev G. G. Aleksandrov L. G. Voskressensky 《Chemistry of Heterocyclic Compounds》2004,40(2):166-176
2-([2,2]-5-Paracyclophanyl)pyrrole has been synthesized and nitration and formylation of it have been effected. The 1--cyanoethyl derivative and 2-formyl-5-paracyclophanyl-3H-pyrrolizine have been obtained from 5-formyl-2-([2,2]-5-paracyclophanyl)pyrrole by the action of acrylonitrile and acrolein respectively under Michael reaction conditions. 相似文献
11.
A. D. Dyachenko S. M. Desenko V. D. Dyachenko A. N. Chernega 《Chemistry of Heterocyclic Compounds》2004,40(8):1009-1016
The condensation of cyclohexylidenemalononitrile or cyclohexylidenecyanoacetic ester with thioamidoethyl(methyl)malonate in the presence of sodium ethylate gave 6-amino-3-carbethoxy-5-cyano-4-spirocyclohexane-1,2,3,4-tetrahydropyridine-2-thione and 3-carbethoxy(methoxy)-5-cyano-6-oxo-4-spirocyclohexanepiperidine-2-thiones which were used in the synthesis of the corresponding substituted 2-alkylthiotetrahydropyridines. 5-Carbethoxy-3-cyano-3-methyl-6-methylthio-4-spiro-cyclohexane-3,4-dihydropyridine-2(1H)-one was studied by X-ray crystallography. 相似文献
12.
Ethyl 2-chloroacetoacetate and its 4-chloro isomer react with cyanoacetamide in the presence of the mild, nonnucleophilic base, triethylamine under stoichiometric conditions to give high yields of ethyl 4-cyano-2-hydroxy-2-methyl-5-oxopyrrolidine-3-carboxylate and ethyl (4-cyano-2-hydroxy-5-oxopyrrolidin-2-yl)acetate, respectively. These, under acid-catalyzed dehydration conditions, afforded ethyl 4-cyano-5-hydroxy-2-methyl-1H-pyrrole-3-carboxylate and ethyl (2Z)-(4-cyano-5-oxopyrrolidin-2-ylidene)ethanoate, respectively. Similarly, the 4-chloro isomer reacted with ethyl cyanoacetate to give the novel product, diethyl 2-cyano-4-oxohexanedioate. The use of triethylamine enables access to a whole new library of pyrrole derivatives from easily accessible, commercially available starting materials. The reactions described in this Letter enable access to libraries of important pyrrole systems in any of the isotopically enriched forms. 相似文献
13.
2 氨基 3 硝基吡啶和2 氨基 5 硝基吡啶的一级质谱图接近,单纯通过一级质谱图较难区分这两种异构体,利用离子阱质谱的串联质谱技术对2 氨基 3 硝基吡啶和2 氨基 5 硝基吡啶在离子阱内以He作碰撞气进行碰撞诱导裂解,所得的二级质谱图表明,两者之间存在明显的差别,可用于2 氨基 3 硝基吡啶和2 氨基 5 硝基吡啶的鉴别。 相似文献
14.
V. N. Nesterov S. G. Krivokolysko V. V. Dotsenko V. P. Litvinov 《Russian Chemical Bulletin》1997,46(5):990-996
The reaction of arylcyanomethylenethiocetamides with Meldrum, acid gave Michael adducts as ammonium salts. When heated in
alcohol, these salts undergo cyclization to ammonium 4-aryl-5-cyano-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolates. The structure
ofN-methylmorpholinium 4-(2′-chlorophenyl)-5-cyano-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolate was established by X-ray structural
analysis.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1029–1034, May, 1997. 相似文献
15.
本文报道了一种通过微波辅助合成5-亚甲基-2,3-二苯基-4-噻唑酮类衍生物的新型方法。在以K2CO3 为碱、H2O 为溶剂、四丁基溴化铵(TBAB)为催化剂的条件下,2,3-二苯基-4-噻唑酮与取代醛在微波辅助下发生Knoevenagel 反应,生成5-亚甲基-2,3-二苯基-4-噻唑酮类衍生物,产率最高可达85%。 相似文献
16.
A one-step procedure was developed for the synthesis of 5-acetyl-2-amino-4-aryl-3-cyano-4H-pyrano[3,2-b]indoles involving the three-component reaction of 1-acetylindol-3(2H)-one with aromatic aldehydes and malononitrile in ethanol in the presence of triethylamine as the catalyst. The structure of 5-acetyl-2-amino-4-(4"-chloro-3"-nitrophenyl)-3-cyano-4H-pyrano[3,2-b]indole was established by X-ray diffraction analysis. 相似文献
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18.
K. S. Chunikhin L. A. Rodinovskaya A. M. Shestopalov 《Chemistry of Heterocyclic Compounds》2007,43(10):1247-1251
The Michael addition of cyanothioacetamide to nitrostyrenes was investigated. Previously unknown 2-amino-4-aryl-3-cyano-5-hydroxyimino-4,5-dihydrothiophenes
were obtained.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1472–1477, October, 2007. 相似文献
19.
1 INTRODUCTION The nature and topography of the herbicide binding site in the reaction center of photosystem Ⅱ (PSⅡ) have been the subject of intense interest for many years. Among several commercially important herbicides with different structures such as atrazine and polypeptide of the PSII reaction center[1], the cyanoacrylates with general structure 1 have proved hightly potent and useful as probes[2, 3] of the receptor because their activities as inhibitors of photosynthetic ele… 相似文献
20.
S. G. Krivokolysko V. D. Dyachenko V. N. Nesterov V. P. Litvinov 《Chemistry of Heterocyclic Compounds》2001,37(3):315-319
The stereoselective synthesis of 3-allyl-4-(4-bromophenyl)-3-cyano-6-oxopiperidine-2-thione has been carried out by refluxing N-methylmorpholinium 5-[1-(4-bromophenyl)-2-cyano-2-thiocarbamoylethyl]-2,2-dimethyl-1,3-dioxa-6-oxo-4-cyclohexen-4-olate with allyl bromide in ethanol. The structure of the product was confirmed by X-ray investigation. 相似文献