Hydromagnetic flow through uniform channel bounded by porous media

The combined effects of the magnetic field, permeable walls, Darcy velocity, and slip parameter on the steady flow of a fluid in a channel of uniform width are studied. The fluid flowing in the channel is assumed to be homogeneous, incompressible,and Newtonian. Analytical solutions are constructed for the governing equations using Beavers-Joseph slip boundary conditions. Effects of the magnetic field, permeability,Darcy velocity, and slip parameter on the axial velocity, slip velocity, and shear stress are discussed in detail. It is shown that the Hartmann number, Darcy velocity, porous parameter, and slip parameter play a vital role in altering the flow and in turn the shear stress.     

Performance modeling and analysis of blood flow in elastic arteries

Nomenclature　　τ　　wallshearstressγshearrateτy yieldstressηc Cassonviscosityktheconsistencyindexnnon_Newtonianindexτp shearstressofthepthelementωangularvelocityRvessel’sradiusCwavespeedM　　magneticparameter (Hartmannnumber)u,w　velocitycomponentinther_andz_directions,respectivelyP　　pressureα　　unsteadinessparameter k , R meanparametersTp relaxationtimeofthepthelementρ densityIntroductionTheimportancetoatherogenesisofarterialflowphenomenasuchasflowseparation ,recirculationands…     

BLOOD FLOW AND MACROMOLECULAR TRANSPORT IN CURVED BLOOD VESSELS

A numerical analysis of the steady/pulsatile flow and macromolecular (such as LDL and Albumin) transport in curved blood vessels was carried out. The computational results predict that the vortex of the secondary flow is time-dependent in the aortic arch. The concentration of macromolecule concentrates at the region of sharp curve, and the wall concentration at the outer part is higher than that at the inner part. Atherosclerosis and thrombosis are prone to develop in such regions with sharp flow.     

Non‐Newtonian blood flow study in a model cavopulmonary vascular system

A transient haemodynamic study in a model cavopulmonary vascular system has been carried out for a typical range of parameters using a finite element‐based Navier–Stokes solver. The focus of this study is to investigate the influence of non‐Newtonian behaviour of the blood on the haemodynamic quantities, such as wall shear stress (WSS) and flow pattern. The computational fluid dynamics (CFD) model is based on an artificial compressibility characteristic‐based split (AC‐CBS) scheme, which has been adopted to solve the Navier–Stokes equations in space–time domain. A power law model has been implemented to characterize the shear thinning nature of the blood depending on the local strain rate. Using the computational model, numerical investigations have been performed for Newtonian and non‐Newtonian flows for different frequencies and input pulse forms. The haemodynamic quantities observed in total cavopulmonary connection (TCPC) for the above conditions suggest that there are considerable differences in average (about 25–40%) and peak (about 50%) WSS distributions, when the non‐Newtonian behaviour of the blood is taken into account. The lower WSS levels observed for non‐Newtonian cases point to the higher risk of lesion formation, especially at higher pulsation frequencies. A realistic pulse form is relatively safer than a sinusoidal pulse as it has more energy distributed in the higher harmonics, which results in higher average WSS values. The present study highlights the importance of including non‐Newtonian shear thinning behaviour for modelling blood flow in the vicinity of repaired arterial connections. Copyright © 2010 John Wiley & Sons, Ltd.     

Two-fluid non-linear model for flow in catheterized blood vessels

Blood flow through a catheterized artery is analyzed, assuming the flow is steady and blood is treated as a two-fluid model with the suspension of all the erythrocytes in the core region as a Casson fluid and the plasma in the peripheral region as a Newtonian fluid. The expressions for velocity, flow rate, wall shear stress and frictional resistance are obtained. The variations of these flow quantities with yield stress, catheter radius ratio and peripheral layer thickness are discussed. It is noticed that the velocity and flow rate decrease while the wall shear stress and resistance to flow increase when the yield stress or the catheter radius ratio increases while all the other parameters were held fixed. It is found that the velocity and flow rate increase while the wall shear stress and frictional resistance decrease with the increase of the peripheral layer thickness. The estimates of the increase in the frictional resistance are significantly very small for the present two-fluid model than those of the single-fluid Casson model.     

A two-fluid model for pulsatile flow in catheterized blood vessels

The pulsatile flow of blood through a catheterized artery is analyzed, assuming the blood as a two-fluid model with the suspension of all the erythrocytes in the core region as a Casson fluid and the peripheral region of plasma as a Newtonian fluid. The resulting non-linear implicit system of partial differential equations is solved using perturbation method. The expressions for shear stress, velocity, flow rate, wall shear stress and longitudinal impedance are obtained. The variations of these flow quantities with yield stress, catheter radius ratio, amplitude, pulsatile Reynolds number ratio and peripheral layer thickness are discussed. It is observed that the velocity distribution and flow rate decrease, while, the wall shear, width of the plug flow region and longitudinal impedance increase when the yield stress increases. It is also found that the velocity increases, but, the longitudinal impedance decreases when the thickness of the peripheral layer increases. The wall shear stress decreases non-linearly, while, the longitudinal impedance increases non-linearly when the catheter radius ratio increases. The estimates of the increase in the longitudinal impedance are considerably lower for the present two-fluid model than those of the single-fluid model.     

Finite element Galerkin Approach for a Computational Study of Arterial Flow

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The steady/pulsatile flow and macromolecular transport in T-bifurcation blood vessels

IntroductionThefluiddynamicsofbloodcyclesystemplayanimportantroleinthepathogenesisofatherosclerosis.ThephysiologicalanatomyfoundthattheatherosclerosisappearsoftenatthebifurcationorcurvedflowareatoallkindsofRefs.[1 ,2 ] .Theshearstressvariesgreatlyinthoseareaandinfluencesthemacromoleculartransportacrossthebloodwall[3,4].Thus ,theinvestigationoftheflowandmacromoleculartransportinthesecomplexbloodvesselaandthecorrelationbetweenthemareinterestingtoresearchers.Intheseaspect,Liepschstudiedtheflowi…     

脉动流条件下动脉狭窄血管内脂质浓度极化现象的计算机数值模拟

在脉动流条件下,用计算机数值模拟的方法对低密度脂蛋白(LDL)在动脉狭窄血管段内的质量传输进行了研究。计算结果表明．无论是在定常流还是在脉动流条件下．LDL都将聚积于血管狭窄处峰口附近的流动分离点,LDL壁面浓度在此处最高。在脉动流条件下,LDL在血流受扰动区的聚积高于定常流的值;而且．流动分离点处LDL壁面浓度峰值覆盖的区域也宽于定常流。本文所揭示出的LDL在血管狭窄处的质量传输现象可能在动脉粥样硬化的局部性和动脉狭窄的形成中起着很重要的作用。     

Numerical studies of blood flow in healthy,stenosed, and stented carotid arteries

Numerical analysis of pulsatile blood flow in healthy, stenosed, and stented carotid arteries is performed with the aim of identifying hemodynamic factors in the initiation, growth, and the potential of leading to severe occlusions of a diseased artery. The Immersed Finite Element Method is adopted for this study to conveniently incorporate various geometrical shapes of arteries without remeshing. Our computational results provide detailed quantitative analysis on the blood flow pattern, wall shear stress, particle residence time, and oscillatory shear index. The analysis of these parameters leads to a better understanding of blood clot formation and its localization in a stenosed and a stented carotid artery. A healthy artery is also studied to establish a baseline comparison. This analysis will assist in developing treatments for diseased arteries and novel stent designs to reduce restenosis. Copyright © 2008 John Wiley & Sons, Ltd.     

Boundary layer development of pulsatile blood flow in a tapered vessel

Assuming that the tapered angle is small,the problems of developing flow under unsteady oscillatory condition are studied in this paper.The formula of velocity distribution is obtained.The analyses for the results show that the blood flow in a converging tapered vessel remains a developing flow throughout the length,and the effects of tapered angle on the developing flow are increased with the increment of the tapered angle.     

THE COUPLE MOTION BETWEEN VESSEL WALL AN DBLOOD IN THE ENTRANCE REGION OF A TAPERED VESSEL

ＴＨＥＣＯＵＰＬＥＭＯＴＩＯＮＢＥＴＷＥＥＮＶＥＳＳＥＬＷＡＬＬＡＮＤＢＬＯＯＤＩＮＴＨＥＥＮＴＲＡＮＣＥＲＥＧＩＯＮＯＦＡＴＡＰＥＲＥＤＶＥＳＳＥＬＣｅｎＲｅｎ－ｊｉｎｇ（岑人经）ＱｉｎＣｈａｎ（秦婵）ＴａｎＺｈｅ－ｄｏｎｇ（谭哲东）（ＳｏｕｔｈＣ...     

提高电化学法测试壁面剪应力精度的方法

应用电化学方法对流场壁面剪应力进行测试在生物力学中有着广泛的用途,静止极限电流在存在将影响壁面剪应力测试的精度,在测试时应根据具体的实验条件进行现场测试,实验表明在测试较低壁面剪应力时,静止极限电流的影响较大;在测试较高壁面剪应力时,则可忽略静止极限电流的影响,极化电压条件下测得极限电流是测试壁面剪应力的基础。为了测试的准确可靠,需对产生极化的外加电压进行实地测试,在测试时,对每个电极都需根据相应的测试条件进行系统标定。     

Bifurcation of flow and mass transport in a curved blood vessel

A numerical analysis of flow and concentration fields of macromolecules in a, slightly curved blood vessel was carried out. Based on these results, the effect of the bifurcation of a flow on the mass transport in a curved blood vessel was discussed. The macromolecules turned out to be easier to deposit in the inner part of the curved blood vessel near the critical Dean number. Once the Dean number is higher than the critical number, the bifurcation of the flow appears. This bifurcation can prevent macromolecules from concentrating in the inner part of the curved blood vessel. This result is helpful for understanding the possible correlations between the blood dynamics and atherosclerosis. The project supported by National Natural Science Foundation of China (10002003), JSPS Postdoctoral Fellowship for Foreign Researcher and Foundation for University Teachers, the Ministry of Education     

Near wall characterization of the flow over a two-dimensional steep smooth hill

Near-wall data for the strongly perturbed flow in a neutrally stable boundary layer encountering a steep, smooth, two-dimensional hill are presented. Observations were made on the centerplane of a water channel at thirteen stations relative to the hill by laser Doppler anemometry. The large reverse flow region that is formed on the lee of the hill was particularly scrutinized through seven measuring stations. Results are presented for the mean and turbulent properties of the flow. Wall shear stress was evaluated through fitting procedures that resorted to the near wall behavior of the velocity profile. Logarithmic fits as well as predictions through the Reynolds stress profiles are also presented.     

Fluid flow and fluid shear stress in canaliculi induced by external mechanical loading and blood pressure oscillation

The paper studies the problem of fluid flow and fluid shear stress in canaliculi when the osteon is subject to external mechanical loading and blood pressure oscillation. The single osteon is modeled as a saturated poroelastic cylinder. Solid skeleton is regarded as a poroelastic transversely isotropic material. To get near-realistic results, both the interstitial fluid and the solid matrix are regarded as compressible. Blood pressure oscillation in the Haverian canal is considered. Using the poroelasticity theory, an analytical solution of the pore fluid pressure is obtained. Assuming the fluid in canaliculi is incompressible, analytical solutions of fluid flow velocity and fluid shear stress with the Navier-Stokes equations of incompressible fluid are obtained. The effect of various parameters on the fluid flow velocity and fluid shear stress is studied.     

平行平板流动腔的数值优化设计

平行平板流动腔系统是研究切应力对细胞影响的体外实验装置之一。前期研究发现,流动腔的高度存在一个最佳高度,使用这个高度可以有效地减小或避免由于装配所引起的高度误差对切应力的影响。为了获得这一最佳高度,本文使用数值方法研究了平行平板流动腔的几何尺寸、流体粘度与集中液阻之间的关系,并拟合得到了集中液阻的函数关系式。利用液阻关系式和切应力计算公式,求得了对底部切应力影响最小的最佳高度的表达式。同时,研究还发现,对于相同的底部切应力,当高度取最佳高度时,所需的入(出)口压差最小。这样在流动腔底部沿轴向的压力梯度也就越小,沿轴向不同位置之间的压力差别也越小,这将有利于细胞力学实验结果之间的比较。     

Blood flow dynamics and fluid–structure interaction in patient‐specific bifurcating cerebral aneurysms

Hemodynamics plays an important role in the progression and rupture of cerebral aneurysms. The current work describes the blood flow dynamics and fluid–structure interaction in seven patient‐specific models of bifurcating cerebral aneurysms located in the anterior and posterior circulation regions of the circle of Willis. The models were obtained from 3D rotational angiography image data, and blood flow dynamics and fluid–structure interaction were studied under physiologically representative waveform of inflow. The arterial wall was assumed to be elastic, isotropic and homogeneous. The flow was assumed to be laminar, non‐Newtonian and incompressible. In one case, the effects of different model suppositions and boundary conditions were reported in detail. The fully coupled fluid and structure models were solved with the finite elements package ADINA. The vortex structure, pressure, wall shear stress (WSS), effective stress and displacement of the aneurysm wall showed large variations, depending on the morphology of the artery, aneurysm size and position. The time‐averaged WSS, effective stress and displacement at the aneurysm fundus vary between 0.17 and 4.86 Pa, 4.35 and 170.2 kPa and 0.16 and 0.74 mm, respectively, for the seven patient‐specific models of bifurcating cerebral aneurysms. Copyright © 2008 John Wiley & Sons, Ltd.     

Computational modeling of biomagnetic micropolar blood flow and heat transfer in a two-dimensional non-Darcian porous medium

We study theoretically and computationally the incompressible, non-conducting, micropolar, biomagnetic (blood) flow and heat transfer through a two-dimensional square porous medium in an (x,y) coordinate system, bound by impermeable walls. The magnetic field acting on the fluid is generated by an electrical current flowing normal to the x–y plane, at a distance l beneath the base side of the square. The flow regime is affected by the magnetization B ₀ and a linear relation is used to define the relationship between magnetization and magnetic field intensity. The steady governing equations for x-direction translational (linear) momentum, y-direction translational (linear) momentum, angular momentum (micro-rotation) and energy (heat) conservation are presented. The energy equation incorporates a special term designating the thermal power per unit volume due to the magnetocaloric effect. The governing equations are non-dimensionalized into a dimensionless (ξ,η) coordinate system using a set of similarity transformations. The resulting two point boundary value problem is shown to be represented by five dependent non-dimensional variables, f _ξ  (velocity), f _η (velocity), g (micro-rotation), E (magnetic field intensity) and θ (temperature) with appropriate boundary conditions at the walls. The thermophysical parameters controlling the flow are the micropolar parameter (R), biomagnetic parameter (N _H ), Darcy number (Da), Forchheimer (Fs), magnetic field strength parameter (Mn), Eckert number (Ec) and Prandtl number (Pr). Numerical solutions are obtained using the finite element method and also the finite difference method for Ec=2.476×10⁻⁶ and Prandtl number Pr=20, which represent realistic biomagnetic hemodynamic and heat transfer scenarios. Temperatures are shown to be considerably increased with Mn values but depressed by a rise in biomagnetic parameter (N _H ) and also a rise in micropolarity (R). Translational velocity components are found to decrease substantially with micropolarity (R), a trend consistent with Newtonian blood flows. Micro-rotation values are shown to increase considerably with a rise in R values but are reduced with a rise in biomagnetic parameter (N _H ). Both translational velocities are boosted with a rise in Darcy number as is micro-rotation. Forchheimer number is also shown to decrease translational velocities but increase micro-rotation. Excellent agreement is demonstrated between both numerical solutions. The mathematical model finds applications in blood flow control devices, hemodynamics in porous biomaterials and also biomagnetic flows in highly perfused skeletal tissue. Dedicated to Professor Y.C. Fung (1919-), Emeritus Professor of Biomechanics, Bioengineering Department, University of California at San Diego, USA for his seminal contributions to biomechanics and physiological fluid mechanics over four decades and his excellent encouragement to the authors, in particular OAB, with computational biofluid dynamics research.     

An unsteady analysis of non-Newtonian blood flow through tapered arteries with a stenosis

The problem of non-Newtonian and nonlinear blood flow through a stenosed artery is solved numerically where the non-Newtonian rheology of the flowing blood is characterised by the generalised Power-law model. An improved shape of the time-variant stenosis present in the tapered arterial lumen is given mathematically in order to update resemblance to the in vivo situation. The vascular wall deformability is taken to be elastic (moving wall), however a comparison has been made with nonlinear visco-elastic wall motion. Finite difference scheme has been used to solve the unsteady nonlinear Navier-Stokes equations in cylindrical coordinates system governing flow assuming axial symmetry under laminar flow condition so that the problem effectively becomes two-dimensional. The present analytical treatment bears the potential to calculate the rate of flow, the resistive impedance and the wall shear stress with minor significance of computational complexity by exploiting the appropriate physically realistic prescribed conditions. The model is also employed to study the effects of the taper angle, wall deformation, severity of the stenosis within its fixed length, steeper stenosis of the same severity, nonlinearity and non-Newtonian rheology of the flowing blood on the flow field. An extensive quantitative analysis is performed through numerical computations of the desired quantities having physiological relevance through their graphical representations so as to validate the applicability of the present model.